Spontaneous choroid plexus carcinoma in an albino rat

Pace, Virgilio

doi:10.1016/s0940-2993(98)80087-0

Cited by 6 publications

(13 citation statements)

References 5 publications

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“…It is thus suggested that the lesion was spontaneous in nature. The age of the occurrence of the present choroid plexus carcinoma (14 weeks old) was much younger than in the preceding cases (Pace, 1998). The present tumor showed a massive growth pattern with expansion, whereas the preceding cases displayed an infiltrative growth pattern or poor differentiation without infiltrative growth Pace, 1998).…”

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confidence: 58%

A Case Report of a Choroid Plexus Carcinoma Spontaneously Occurring in the Right Lateral Ventricle of a 14-Week-Old, Female Donryu Rat

Shimomoto

Yoshida²,

Takahashi³

et al. 2004

Toxicol Pathol

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We encountered a brain tumor arising in the right lateral ventricle of a 14-week-old, female Donryu rat and investigated its histological and immunohistochemical characteristics. Macroscopically, the tumor appeared as a grayish mass with a size of 10 mm in diameter, present in front of the right hemicerebrum and well circumscribed on the cut surface. Histological examination revealed the tumor to be a hypercellular mass occupying the front part of the right lateral ventricle and expanding into the area in front of the hemicerebrum, continuing to the ependymal area at its edge. The tumor was constituted by columnar- or pleomorphic-shaped, highly atypical cells of epithelial origin surrounding fibrovascular cores as single or multiple cell layers. Growth was papillary with high proliferating activity. Immunohistochemically, the tumor cells proved positive for cytokeratin but negative for vimentin, S100 protein or glial fibrillary acidic protein, a profile characteristic for the epithelial cells of the choroid plexus, whereas the ependymal cells were found to be positive for all 4 items. In conclusion, the present tumor was diagnosed as a rat choroid plexus carcinoma, only the third such case to be reported in the world literature, with particular features.

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confidence: 58%

A Case Report of a Choroid Plexus Carcinoma Spontaneously Occurring in the Right Lateral Ventricle of a 14-Week-Old, Female Donryu Rat

Shimomoto

Yoshida²,

Takahashi³

et al. 2004

Toxicol Pathol

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“…Biological behavior: benign neoplasm Synonym/synonyms: none Histogenesis: epithelial cells of the choroid plexus Diagnostic features: characteristics were compiled from Thompson et al 1961;Wechsler, Rice, and Vesselinovitch 1979;Morgan et al 1984;Dickson et al 1985;Marks et al 1989;Chandra, Riley, and Johnson 1992;Koestner et al 1999;Pace 1998;Radovsky and Mahler 1999 mass arises from the choroid plexus and exhibits the following cytoarchitectural features of malignancy: invasive growth into the adjacent brain, cellular atypia and pleomorphism, and prominent pseudostratification (piling up); mitotic rate is variable, but mitoses are present. In dogs, papillomas stain with cytokeratin antibodies.…”

Section: Papilloma Choroid Plexus (Figures 125 and 126)mentioning

confidence: 99%

Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems

et al. 2012

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Harmonization of diagnostic nomenclature used in the pathology analysis of tissues from rodent toxicity studies will enhance the comparability and consistency of data sets from different laboratories worldwide. The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of four major societies of toxicologic pathology to develop a globally recognized nomenclature for proliferative and nonproliferative lesions in rodents. This article recommends standardized terms for classifying changes observed in tissues of the mouse and rat central (CNS) and peripheral (PNS) nervous systems. Sources of material include academic, government, and industrial histopathology databases from around the world. Covered lesions include frequent, spontaneous, and aging-related changes as well as principal toxicant-induced findings. Common artifacts that might be confused with genuine lesions are also illustrated. The neural nomenclature presented in this document is also available electronically on the Internet at the goRENI website (http://www.goreni.org/).

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“…Medulloblastoma has been described both in rats and (17,19,35,69,70,78) (Table 7). Certain tumorlike lesions, such as lipomas (lipomatous hamartoma) and epidermoid cysts, appear to be more frequent in mice than in rats (3,48 (14,102).…”

Section: Comments On the Reports Dealing With Spontaneous Primary Rodmentioning

confidence: 99%

Morphologic Characterization of Spontaneous Nervous System Tumors in Mice and Rats

et al. 2000

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Spontaneous choroid plexus carcinoma in an albino rat

Cited by 6 publications

References 5 publications

A Case Report of a Choroid Plexus Carcinoma Spontaneously Occurring in the Right Lateral Ventricle of a 14-Week-Old, Female Donryu Rat

A Case Report of a Choroid Plexus Carcinoma Spontaneously Occurring in the Right Lateral Ventricle of a 14-Week-Old, Female Donryu Rat

Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems

Morphologic Characterization of Spontaneous Nervous System Tumors in Mice and Rats

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