Morphologic Characterization of Spontaneous Nervous System Tumors in Mice and Rats

Krinke, G.; Kaufmann, Wolfgang; Mahrous, A. T.; Schaetti, P.

doi:10.1177/019262330002800123

Cited by 63 publications

(73 citation statements)

References 73 publications

(40 reference statements)

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“…Spontaneous rodent tumors in the brain are less differentiated than their human counterparts. Morphologic characteristics of CNS tumors in rats and mice, including CP papillomas and ependymomas, have been thoroughly treated (Krinke et al 2000). Microbial and immune cell permeation of CP have also been widely documented (Engelhardt and Sorokin 2009;Petito 2004).…”

Section: Toxicology and Pathology Models Of Damage To Csfbordering Cellsmentioning

confidence: 99%

The Distributional Nexus of Choroid Plexus to Cerebrospinal Fluid, Ependyma and Brain

et al. 2010

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Bordering the ventricular cerebrospinal fluid (CSF) are epithelial cells of choroid plexus (CP), ependyma and circumventricular organs (CVOs) that contain homeostatic transporters for mediating secretion/reabsorption. The distributional pathway (''nexus'') of CP-CSF-ependyma-brain furnishes peptides, hormones, and micronutrients to periventricular regions. In disease/toxicity, this nexus becomes a conduit for infectious and xenobiotic agents. The sleeping sickness trypanosome (a protozoan) disrupts CP and downstream CSF-brain. Piperamide is anti-trypanosomic but distorts CP epithelial ultrastructure by engendering hydropic vacuoles; this reflects phospholipidosis and altered lysosomal metabolism. CP swelling by vacuolation may occlude CSF flow. Toxic drug tools delineate injuries to choroidal compartments: cyclophosphamide (vasculature), methylcellulose (interstitium), and piperazine (epithelium). Structurally perturbed CP allows solutes to penetrate the ventricles. There, CSF-borne pathogens and xenobiotics may permeate the ependyma to harm neurogenic stem cell niches. Amoscanate, an anti-helmintic, potently injures rodent ependyma. Ependymal/brain regions near CP are vulnerable to CSF-borne toxicants; this proximity factor links regional barrier breakdown to nearby periventricular pathology. Diverse diseases (e.g., African sleeping sickness, multiple sclerosis) take early root in choroidal, circumventricular, or perivascular loci. Toxicokinetics informs on pathogen, anti-parasitic agent, and auto-antibody distribution along the CSF nexus. CVOs are susceptible to plasma-borne toxicants/pathogens. Countering the physico-chemical and pathogenic insults to the homeostasis-mediating ventricle-bordering cells sustains brain health and fluid balance.

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Section: Toxicology and Pathology Models Of Damage To Csfbordering Cellsmentioning

confidence: 99%

The Distributional Nexus of Choroid Plexus to Cerebrospinal Fluid, Ependyma and Brain

et al. 2010

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“…On the other hand, there are no reports describing the existence of GFAP-positive neoplastic astrocytes in rat spontaneous astrocytomas, although detailed immunohistochemical examinations have been done by many researchers (Krinke and Germer 1993;Krinke et al 2000;Nagatani et al 2009;Pruimboom-Brees et al 2004;Solleveld, Gorgacz, and Koestner 1991;Weber et al 2011).…”

Section: Introductionmentioning

confidence: 99%

GFAP-Positive Neoplastic Astrocytes in Spontaneous Oligodendrogliomas and Mixed Gliomas of Rats

et al. 2012

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It is generally said that neoplastic cells are immunohistochemically negative for glial fibrillary acidic protein (GFAP) in rat spontaneous astrocytomas, and there are no reports describing the existence of GFAP-positive neoplastic astrocytes in rat spontaneous oligodendrogliomas and mixed gliomas which contain neoplastic astrocytes. In the present study, to clarify whether GFAP-positive neoplastic astrocytes exist in rat spontaneous oligodendrogliomas and mixed gliomas or not, immunohistochemical examination was performed on spontaneous oligodendrogliomas (26 cases) and mixed gliomas (5 cases) collected from the carcinogenicity studies and short-term toxicity studies. The neoplastic cells that constitute oligodendrogliomas and mixed gliomas were morphologically classified into five types: round A, round B, round C, spindle, and bizarre. The cells of round A, B, and C types were thought to be neoplastic oligodendrocytes because of their positive immunostainability for Olig2. The origin of bizarre cells was obscure because they were negative for Olig2, GFAP, and nestin. The spindle cells were considered to be neoplastic astrocytes, because some of them were positive for GFAP or nestin, and GFAP-positive spindle cells could be morphologically distinguished from reactive astrocytes. In conclusion, the present study clarified for the first time that GFAP-positive neoplastic astrocytes exist in rat spontaneous gliomas.

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“…Most human intracranial GCTs from neurohypophysis are considered to be derived from specialized pituicytes or to originate from Schwann cells or astrocytes [16,19]. In rats, GCTs are located in or adjacent to the meninges of the cranial cavity, and the histogenesis has been regarded as a progenitor meningiothelial arachnoid cell because of their anatomic location, and immunohistochemical and/or electron microscopic features [10,11,20]. An astrocytic origin has been postulated based on positive immunohistochemistry for GFAP, vimentin, and S-100 protein [15].…”

mentioning

confidence: 99%

Intracranial Granular Cell Tumor in a Dog

Liu

Liang

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. A 12-year-old female miniature poodle showed a 3-month history of neurological signs. Magnetic resonance imaging disclosed a high intensity tumor mass in the right cerebral hemisphere with compression of the lateral ventricle. At necropsy, a 2 × 3 cm white, friable mass was found in the right ventral pyriform lobe. Microscopically, the tumor cells were large, polygonal to round cells supported by a sparse fibrovascular stroma. The tumor cells typically possesed finely granular, pale eosinophilic cytoplasm with strongly positive periodic acid-Schiff (PAS) reaction. The tumor cells were immunopositive for vimentin, NSE and S-100. Ultrastructurally, the tumor cells showed large amounts of granules in the cytoplasm, and absence of basement membrane. Based on the above-mentioned findings, the intracranial granular cell tumor was diagnosed.

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Morphologic Characterization of Spontaneous Nervous System Tumors in Mice and Rats

Cited by 63 publications

References 73 publications

The Distributional Nexus of Choroid Plexus to Cerebrospinal Fluid, Ependyma and Brain

The Distributional Nexus of Choroid Plexus to Cerebrospinal Fluid, Ependyma and Brain

GFAP-Positive Neoplastic Astrocytes in Spontaneous Oligodendrogliomas and Mixed Gliomas of Rats

Intracranial Granular Cell Tumor in a Dog

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