Intracranial Granular Cell Tumor in a Dog

Liu, Chen-Hsuan; Liu, Chen-I; Liang, Sao-Ling; Cheng, Chiung-Hsiang; Huang, Sun-Chau; Lee, Chin-Cheng; Hsu, Wei-Chih; Lin, Yung‐Chang

doi:10.1292/jvms.66.77

Cited by 20 publications

(31 citation statements)

References 15 publications

(32 reference statements)

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“…1 Canine cerebral GCTs appeared to be of meningeal cell origin 2 or mesenchymal and neural nature. 3 The tumor under study appeared to develop outside the neural parenchyma and histologic examination showed features commonly observed in meningeal tumors, such as psammoma body-like patterns and areas of cholesterol degeneration. Based on the negative staining for GFAP expression, the tumor was not considered to be of astrocytic derivation.…”

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confidence: 88%

A Cerebral Granular Cell Tumor in a Cat

Ricci¹,

Sforna²

2006

Vet Pathol

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Abstract. A cerebral granular cell tumor is described in a 6-year-old, shorthaired, female cat. The tumor was observed above the corpus callosum and completely infiltrating the third ventricle. Histologic examination revealed that the tumor was characterized by large cells containing densely packed intracytoplasmic granules and expressed psammoma body-like patterns and cholesterinic degeneration. Immunohistochemical analysis revealed granular neoplastic cells that were diffusely and strongly vimentin-positive, while they did not express cytokeratins, lysozyme, and synaptophysin. Based on morphologic and immunohistochemical findings, the tumor under study was considered to be of meningeal origin arising directly from the meninges or from meningeal elements scattered in the tela choroidea of the third ventricle roof.

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confidence: 88%

A Cerebral Granular Cell Tumor in a Cat

Ricci¹,

Sforna²

2006

Vet Pathol

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“…97 Granular cell meningioma has been considered an uncommon variant of meningioma but is probably a completely unrelated tumor. Its staining properties are variable in dogs 43,70 and a cat. 78 Granular cell tumors are also occasionally found intra-axially.…”

Section: Meningiomasmentioning

confidence: 99%

Diagnostic Immunohistochemistry of Canine and Feline Intracalvarial Tumors in the Age of Brain Biopsies

2013

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The focus of immunohistochemistry as applied to nervous system tumors is in identifying the neoplasm present and evaluating margins between normal and neoplastic tissue. Although not always utilized by specialists in neuropathology, immunohistochemistry remains useful to resolve concerns about the differentiation and rate of tumor growth. The aims of this review are to discuss the utility of immunohistochemical reagents currently used in diagnosis of canine and feline intracalvarial tumors, to indicate the applicability of some tests currently used in human nervous system tumors for domestic species, and to evaluate a few less commonly used reagents. A panel of biomarkers is usually needed to confirm a diagnosis, with groups of reagents for leptomeningeal, intraparenchymal, and ventricular neoplasms. In the future, signature genetic alterations found among feline and canine brain tumors-as correlated prospectively with diagnosis, rate of enlargement, or response to treatment-may result in new immunohistochemical reagents to simplify the task of diagnosis. Prospective studies determining the type and proportion of stem cell marker expression on patient longevity are likely to be fruitful and suggest new therapies. Due to increased frequency of biopsy or partial resection of tumors from the living patient, biomarkers are needed to serve as accurate prognostic indicators and assist in determining the efficacy of developing therapeutic options in nervous system tumors of dogs and cats.

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“…In fact, GCT is the most common intracranial tumor in rats. 35 However, fewer than a dozen reports of GCTs in the CNS of dogs exist in the literature, 3,[13][14][15]19,26 and there is only 1 report of GCTs in the peripheral nervous system of dogs. 18 The histogenesis remains disputed.…”

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confidence: 99%

Granular Cell Tumor in a Lumbar Spinal Nerve of a Dog

et al. 2010

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Abstract.A 2-year-old Great Dane dog with a 2.5-week history of progressive paraparesis was presented to the Veterinary Medical Teaching Hospital at the University of Wisconsin-Madison. Neurologic examination revealed nonambulatory paraparesis with reduced to absent withdrawal hind-limb reflexes and lumbar pain. Magnetic resonance imaging and gross pathology confirmed a larger regional lumbar mass and a second smaller extradural mass within the spinal canal. The left lumbar mass was associated with extensive hemorrhage; dissection showed a dark-red, soft, well-circumscribed mass measuring 2 cm 3 1.5 cm 3 0.5 cm within the left fourth lumbar spinal nerve. Histopathological evaluation with immunohistochemistry revealed sheets of round to polygonal cells with diffuse granular cytoplasm demonstrating diastase-resistant periodic acid-Schiff reactivity and positive immunoexpression of S100 and neuron-specific enolase. The smaller extradural mass within the spinal canal exhibited similar morphology. Based on gross, histological, and immunohistochemical evidence, the masses were diagnosed as granular cell tumor.

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Intracranial Granular Cell Tumor in a Dog

Cited by 20 publications

References 15 publications

A Cerebral Granular Cell Tumor in a Cat

A Cerebral Granular Cell Tumor in a Cat

Diagnostic Immunohistochemistry of Canine and Feline Intracalvarial Tumors in the Age of Brain Biopsies

Granular Cell Tumor in a Lumbar Spinal Nerve of a Dog

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