A Cerebral Granular Cell Tumor in a Cat

Ricci, Giampietro; Sforna, Monica

doi:10.1354/vp.43-5-797

Cited by 16 publications

(22 citation statements)

References 8 publications

(16 reference statements)

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“…Deposition of cholesterol crystals is a feature frequently observed in feline meningiomas [24]. Particularly, the "granular-cell" subtype, whose meningeal origin is however on debate, shows remarkable deposits of cholesterol crystals in a sheet of pleomorphic, sometimes multinucleated, round PAS-positive granular cells [12]. In our case, the lesion was exclusively constituted by lipid-laden, PAS-negative, HAM-56-positive macrophages with many old and recent multifocal haemorrhages.…”

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confidence: 53%

Intracranial Cholesterol Granuloma in a Cat

Ricci

Abbiati²,

Cantile

2010

The Journal of Veterinary Medical Science

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ABSTRACT. A case of intracranial cholesterol granuloma is described in a 4-year-old neutered European male cat presented with a 5-month history of progressive weakness, ataxia and depression. On clinical evaluation, haematological and biochemical profiles revealed only mild hypercholesterolemia and magnetic resonance imaging showed a large space-occupying extra-axial mass in the area of the falx, not homogeneous after contrast enhancement. At post-mortem examination, an orange-yellowish mass of 22 mm in diameter extended from the right frontal lobe to the temporo-parietal region, causing atrophy of the prosencephalic region of the brain. The site of origin of the mass was within the subarachnoid space of the supracallosum sulcus of the right cerebral hemisphere. Histological examination of the lesion revealed abundant deposits of cholesterol clefts, surrounded by clusters of macrophages and multinucleated giant cells. Neither inflammatory lesions, nor cholesterol deposits were detected in other areas of the brain and in other organs. On the basis of the histological examination, a diagnosis of intracranial cholesterol granuloma was made.KEY WORDS: cholesterol granuloma, feline, MRI, nervous system disease.J. Vet. Med. Sci. 72(11): 1475-1478, 2010 Cholesterol granulomas (CGs) are known as well circumscribed, non neoplastic lesions, resulting from a chronic inflammatory reaction to continuous deposition of cholesterol crystals [10]. In human beings, a diagnosis of CG has been established in several sites throughout the body, comprising the intracranial localisation [4,13,20].In veterinary medicine, the development of an intracranial cholesterol granuloma has been described as an incidental, asymptomatic finding at necropsy in 20% of older horses and the choroid plexus of fourth and lateral ventricles represented the preferential location of the so-called "cholesteatoma of the choroid plexus" [9]. Sporadic descriptions of identical intracranial lesions have been reported in other animals, such as meerkats (Suricata suricatta sp., family Herpestidae) [2,21,22] A 4 year-old neutered male cat was presented at the "Malpensa" Veterinary Clinic (Samarate, Italy) with a 5-month history of progressive weakness, ataxia and depression. The cat was previously treated with prednisone with partial remission of clinical signs. On clinical examination, the cat appeared dehydrated and in poor general condition. At presentation the cat exhibited aggressive behaviour and only a limited number of neurological tests could be performed. Neurological examination revealed proprioceptive deficits in all four limbs, no evident abnormality of cranial nerves and a poor bilateral menace reaction. On the basis of the clinical data, a forebrain lesion was suspected. Differential diagnoses included encephalitis, neoplasia, toxic, metabolic or nutritional encephalopathy. Haematological and biochemical profiles revealed moderate hyperglycaemia (343 mg/dl, normal range: 60-175 mg/dl) and mild hypercholesterolemia (236 mg/dl, normal range: 97-207 mg...

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confidence: 53%

Intracranial Cholesterol Granuloma in a Cat

Ricci

Abbiati²,

Cantile

2010

The Journal of Veterinary Medical Science

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“…The presence of cholesterol clefts is a well-recognized feature of feline meningiomas; 12 however, they have also been documented in a case of feline meningeal granular cell neoplasia. 6 After the initial histopathologic assessment, meningeal granular cell neoplasia was also considered as a differential diagnosis. In the case reported by Mandara et al, 6 the granular cells were characterized by the presence of PAS-positive cytoplasmic granules inconsistently positive for S100 and were diffusely immunoreactive for vimentin and occasionally positive for progesterone receptor.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Exercise

et al. 2014

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A 4-year old spayed male domestic shorthair cat was presented with a history of circling and behavioral changes. Neurologic examination showed mild proprioceptive deficits. The lesion was localized in the forebrain, and magnetic resonance imaging revealed the presence of a large midline intracranial mass extending from the frontal lobe to the tentorial region of the brain. Euthanasia was elected due to poor prognosis. Histopathologic evaluation confirmed the presence of a mass composed by sheets and aggregates of large round/polygonal cells and multinucleate cells associated with deposits of cholesterol clefts, scattered hemorrhages and hemosiderin-laden macrophages. Immunohistochemistry showed that the round/polygonal cells and multinucleate cells were strongly positive for major histocompatibility complex class II antigen, variably positive for CD18, and occasionally positive for S100. Subsets of spindle cells showing variable expression of vimentin, S100, and neuron-specific enolase were also present. The final diagnosis was cholesterol granuloma. Differential diagnosis with meningioma is discussed.

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“…GCTs comprise a large number of neoplasms occurring both within the nervous system and extraneurally ( Mandara et al . ). Central nervous system (CNS) GCTs have been documented extensively in humans and rats ( Yoshida et al .…”

Section: Introductionmentioning

confidence: 97%

“…Granular cell tumours (GCTs) are rare neoplasms of uncertain histogenesis which have been reported in a variety of species including humans, horses, dogs, cats, ferrets and cockatiels (Patnaik 1993, Liu et al 2004, Higgins et al 2017. GCTs comprise a large number of neoplasms occurring both within the nervous system and extraneurally (Mandara et al 2006). Central nervous system (CNS) GCTs have been documented extensively in humans and rats (Yoshida et al 1997, Li et al 2016.…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, domestic animals seem to be rarely affected. To date, intracranial GCTs have been described in 16 dogs (Parker et al 1978, Patnaik 1993, Barnhart et al 2001, Higgins et al 2001, Liu et al 2004, Sharkey et al 2004, Klopp & Ridway 2009, Regan et al 2011, Mishra et al 2012, Anwer et al 2013) and one cat (Mandara et al 2006), whereas spinal GCTs have been reported only in two dogs (Montoliu et al 2006, Rao et al 2010.…”

Section: Introductionmentioning

confidence: 99%

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Intradural extramedullary granular cell tumour in a cat

Valentini

Canal²,

Balducci³

et al. 2018

J of Small Animal Practice

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A 7-year-old domestic shorthair cat was evaluated for progressive paraparesis, inability to jump, a paralysed tail and inability to void the bladder. Neurologic examination was consistent with a L4-S3 localisation. Survey radiographs of the lumbar vertebral column revealed L4-L7 vertebral body remodelling. A pre-contrast T1-weighted hyperintense, diffusely enhancing intradural lesion extending from L4 to S1 vertebral bodies was detected by MRI. Large, mesenchymal, round-to-polygonal cells arranged in nests or sheets were found on histologic examination at post mortem. These cells were characterised by abundant intracytoplasmic PAS-positive, diastase-resistant granules and positive immunoexpression of vimentin, S-100, neuron-specific enolase and desmin. This is the first report of a spinal granular cell tumour in a cat.

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A Cerebral Granular Cell Tumor in a Cat

Cited by 16 publications

References 8 publications

Intracranial Cholesterol Granuloma in a Cat

Intracranial Cholesterol Granuloma in a Cat

Diagnostic Exercise

Intradural extramedullary granular cell tumour in a cat

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