Spontaneous Bilateral Subhyaloid Hemorrhage in Congenital Hypofibrinogenemia

Abstract

Estimation of fibrinogen in the absence of other evaluated causes of blood dyscrasias would help with prompt diagnosis and successful management.

Endogenous Endophthalmitis in a Two-Week-Old Neonate with Hypofibrinogenemia

“…In our patient with hypofibrinogenemia, the most plausible explanation of the rapid deterioration of his eye condition and lack of response to proper treatment is the presence of intraocular blood which acted as a culture medium for this virulent bacteria. Spontaneous bilateral subhyaloid hemorrhage in congenital hypofibrinogenemia has been previously reported [10].…”

“…A large series of neonatal endogenous endophthalmitis reported a mean interval of seven days between onset of symptoms and referral [10]. Early diagnosis of endophthalmitis in children can be challenging because they may not be able to verbalize symptoms such as decreased visual acuity, photophobia or pain.…”

Recurrent vitreous haemorrhage and epidural haematoma in a child with hypofibrinogenaemia

“…There are three case reports in the literature describing paediatric patients with intraocular bleeding secondary to hypofibrinogenaemia. Pathengay et al 7described bilateral visual loss to 6/24 (20/80) right eye and 6/360 (20/1200) left eye from spontaneous subhyaloid haemorrhage in a 14-year-old girl. Clotting profile showed normal activated partial thromboplastin time and normal prothrombin time with fibrinogen decreased to 0.5 g/l.…”