Spontaneous/Background Pathology of Göttingen Minipig

McAnulty, Peter A.; Dayan, Anthony D.; Ganderup, Niels-Christian; Hastings, Kenneth L.

doi:10.1201/b11356-26

Cited by 5 publications

(61 citation statements)

References 6 publications

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“…Â5. degenerated adipocytes (Dincer and Skydsgaard 2012). Serous atrophy of the bone marrow fat was a common finding in minipigs in EU (11.75%; Figure 11), whereas it was not reported at all in NA animals.…”

Section: Cardiovascular: (Supplementalmentioning

confidence: 98%

“…The most common findings in skeletal muscle of Göttingen minipigs were degeneration (1.7% NA and 0% EU), degeneration and regeneration of myofibers (0.1% NA and 5.4% EU), and inflammatory cell infiltrate (1.9% NA and 0.3% EU). Degenerate and regenerating myofibers have previously been reported (Dincer and Skydsgaard 2012).…”

Section: Cardiovascular: (Supplementalmentioning

confidence: 99%

“…Thrombocytopenic purpura has previously been reported as a finding in Göttingens in both NA and the EU (Carrasco et al 2003;Dincer and Skydsgaard 2012;Maratea, Snyder, and Stevenson 2006), and subsequent breeding strategies have attempted to eliminate it. In this study, thrombocytopenic purpura was only reported in 1 male >6 months of age from the EU cohort.…”

Section: Systemicmentioning

confidence: 99%

“…Hemorrhage (7.6% NA and 0% EU), lymphoid depletion (3.8% NA and 0% EU), and mineral deposition (0.7% NA and 1.5% EU) were the most common background observations in the Göttingen minipig thymus. Due to the anatomical location within the cervical region, the thymus may be injured during blood collection (Dincer and Skydsgaard 2012;Jeppesen and Skydsgaard 2015).…”

Section: Cardiovascular: (Supplementalmentioning

confidence: 99%

“…This study was undertaken to determine if there are breed or population (geographic location)-based differences in the incidence and nature of commonly occurring background pathology. There have been a few reports out of the EU discussing background changes (Dincer and Skydsgaard 2012;Jeppesen and Skydsgaard 2015;Svendsen et al 1998); however, these studies were undertaken primarily at one geographical site. Presented here is a multisite study that includes data from 1,390 Göttingen, 118 Hanford, and 88 Yucatan subjects.…”

Section: Introductionmentioning

confidence: 99%

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Background Pathological Changes in Minipigs

et al. 2015

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Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety assessment of small molecules, biopharmaceutical agents, and medical devices as an alternate nonrodent species. Although swine have been used extensively in biomedical research, there is a paucity of information in the current literature detailing the incidence of background lesions and differences in incidence between commonly used breeds. This article is a collaborative effort between multiple organizations to define and document lesions found in the common breeds of minipigs used for toxicological risk assessment in North America (NA) and the European Union (EU). We retrospectively assessed 10 years of historical control data from several institutions located in NA and EU, covering the period of 2004-2015. Here we report the background lesions with consideration of breed and geographical location. To our knowledge, this is the first report documenting spontaneous background lesions in commonly used breeds of swine in both NA and EU. This report serves as a resource to pathologists and will aid in interpretation of findings and differentiation of background from test article-related changes.

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Section: Cardiovascular: (Supplementalmentioning

confidence: 98%

Section: Cardiovascular: (Supplementalmentioning

confidence: 99%

Section: Systemicmentioning

confidence: 99%

Section: Cardiovascular: (Supplementalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Background Pathological Changes in Minipigs

et al. 2015

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Biology and Diseases of Swine

Helke

Ezell

Duran‐Struuck

et al. 2015

Laboratory Animal Medicine

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Spontaneous and Drug-induced Arteritis/Polyarteritis in the Göttingen Minipig—Review

et al. 2018

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Arteritis/polyarteritis occurs spontaneously in many species used in preclinical toxicology studies. In Göttingen minipigs, arteritis/polyarteritis is an occasionally observed background change. In the minipig, this finding differs in frequency and nature from age-related polyarteritis nodosa in rats or monkeys, and Beagle pain syndrome in dogs. In minipigs, it can be present in a single small- or medium-sized artery of an organ or a few organs and is most commonly recorded in the cardiac and extracardiac blood vessels, vagina, oviduct, rectum, epididymis, spinal cord, pancreas, urinary bladder, kidneys, and stomach. The etiology is unknown although it has been considered in minipigs as well as in rats, dogs, and monkeys to be possibly immune mediated. This background change is important with respect to its nature and distribution in the minipig in order to distinguish it from drug-induced vascular changes, which might occur in similar locations and have similar morphologic features. This review summarizes the morphology, incidence, and predilection sites of arteritis as a spontaneously occurring background change and as a drug-induced vasculopathy in the minipig, and also describes the main aspects to consider when evaluating vascular changes in Göttingen minipig toxicity studies and their human relevance.

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Spontaneous/Background Pathology of Göttingen Minipig

Cited by 5 publications

References 6 publications

Background Pathological Changes in Minipigs

Background Pathological Changes in Minipigs

Biology and Diseases of Swine

Spontaneous and Drug-induced Arteritis/Polyarteritis in the Göttingen Minipig—Review

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