Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma

Felice, Francesca Di; Zaina, Fabio; Donzelli, Sabrina; Négrini, Stefano

doi:10.1007/s00586-017-5063-1

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…[ 11 ] Patients who have partially regained the vertebral body height have been reported. [ 9 12 ] CT-guided intralesional injection of corticosteroids has been proved effective and safe with good responses in the literature, recommended for patients who are neurologically intact and without a structural deformity or surgery could not be performed. [ 5 13 ] Corticosteroids are thought to inhibit the release of secretion of ILs and prostaglandins as bone resorptive agents from Langerhans cells.…”

Section: Discussionmentioning

confidence: 99%

First technical report of a pediatric case with thoracic Langerhans cell histiocytosis: Gross total tumor removal, corpectomy, and 360° stabilization via posterolateral approach at a single stage

Erdogan

Solmaz

Doğan

2021

J Craniovert Jun Spine

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Background: Langerhans cell histiocytosis (LCH) is a rare nonmalignant disease characterized by a clonal proliferation of mononuclear cells called Langerhans histiocytes and infiltrates surrounding tissues, mostly self-limiting and usually occurring in the first two decades of life. Vertebral involvement is rare, mostly seen in the thoracic region, and involves the anterior elements of the corpus. In the literature, several treatment options and surgical approaches have been reported concerning the treatment of this disease and surgery. Case Presentation: We report an 18-month-old male with thoracic LCH who underwent surgery due to progressive neurological deficit. Gross total removal of the tumor with one level corpectomy in this patient was achieved via a posterolateral approach with postoperative functional improvement. The surgical cavity was supported by corpectomy cage and unilateral screw-rod fixation system at the same stage. Conclusion: Gross total tumor removal, corpectomy, and 360° stabilization via posterolateral approach at a single stage are safe, effective, and definite neurosurgical methods in terms of providing neurological recovery, long-term tumor-free survival, and spinal stability.

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Section: Discussionmentioning

confidence: 99%

First technical report of a pediatric case with thoracic Langerhans cell histiocytosis: Gross total tumor removal, corpectomy, and 360° stabilization via posterolateral approach at a single stage

Erdogan

Solmaz

Doğan

2021

J Craniovert Jun Spine

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“…The pain is not dependent upon activity, and the characteristic night pain may be present [14]. Eosinophilic granuloma and Langerhans histiocytosis may cause back pain with "vertebra plana" findings on imaging studies [15]. Tumors of neural tissue, such as schwannomas, may cause radiculopathic pain.…”

Section: Tumormentioning

confidence: 99%

A Quick and Comprehensive Guide to Differential Diagnosis of Neck and Back Pain: a Narrative Review

Krasin

Schermann

Snir

et al. 2022

SN Compr. Clin. Med.

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The list of diagnostic options when approaching a patient with axial pain is impressively complex. Many offer limited diagnostic workups, but we could not find a truly comprehensive diagnostic guide to assist in the diagnostic evaluation. In this short paper, we briefly described a long list of medical conditions, each of which can manifest as back or neck pain, and whose prevalence ranges from common to very rare. We then proposed an algorithm for classifying them into subgroups. Further referral to diagnostic tests and specialist consultations, after assignment to one of those subgroups, could save time and unnecessary tests. We believe that this review and the proposed diagnostic algorithm can be valuable for medical education and for use in the primary care setting for the diagnostic evaluation of any type of back or neck pain in all patient groups.

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“…Кроме того, описано применение исключительно методов химио -и лучевой терапии, особенно при многоуровневых поражениях, в том числе в сочетании с неврологическими проявлениями. Показа ниями к декомпрессии при этом считают отсутствие эффек та от консервативной терапии или быстрое нарастание неврологической симптоматики [17][18][19][20].…”

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Pathological fractures of the spine in children (review of the literature and clinical and morphological monocenter cohort analysis)

Зорин

Иванович²,

Mushkin

et al. 2020

Pediatr Traum Orthop Reconstr Surg

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Background. Pathological vertebral fractures are rare and occur in inflammatory, tumor, and dystrophic lesions. Aim. This study aimed to analyze clinical features and morphological structure of pathological fractures of the spine in children. Materials and methods. The authors examined and operated 62 children aged 217 years for pathological vertebral fractures. We investigated the clinical, radiological, and morphological features. Results. The average age of children at the time of hospitalization was 10 years. Lesions of thoracic vertebrae prevailed (78%) with the maximum frequency of occurrence at the apex of physiological kyphosis Th78. In 10 cases, multiple lesions were noted, including the pathology of other parts of the skeleton. In 69% of observations, clinical symptoms were not dominated by mechanical back pain. Palpation pain (34%) and local spinal deformation (27%) were noted. On average, local kyphosis was 24. Eleven patients (18%) manifested a neurological deficiency, of which nine fractures were a consequence of the tumor process. In 16% of observations, the fracture of the vertebra was detected to be an accidental Х-ray finding. Among the radiation manifestations, all cases (12 patients) registered the decrease in the height of the vertebral body in the form of collapse. Destruction was manifested by various options other than blastic. Therapeutic and diagnostic interventions were performed in 56 patients, and in six children, manipulation was limited to trepan biopsy. The pathological fracture was caused by an inflammatory process in 50% of observations and tumors in 42%, of which 31% is malignant. Conclusions. Pathological spinal fracture in children should be considered as a syndrome, which in most cases is based on an inflammatory or tumor process. The high frequency of neoplastic, including malignant processes, requires active invasive diagnosis. Therapeutic tactics are determined by the clinical, radiation, and morphological characteristics of pathology.

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Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma

Abstract: Despite the rarity of the condition and despite the rarity of vertebral body lesion resolution, total vertebral body reconstruction was observed over a 7-year period. Long-term follow-up is necessary for a better understanding of the final outcome of patients with EG.

Cited by 7 publications

References 14 publications

First technical report of a pediatric case with thoracic Langerhans cell histiocytosis: Gross total tumor removal, corpectomy, and 360° stabilization via posterolateral approach at a single stage

First technical report of a pediatric case with thoracic Langerhans cell histiocytosis: Gross total tumor removal, corpectomy, and 360° stabilization via posterolateral approach at a single stage

A Quick and Comprehensive Guide to Differential Diagnosis of Neck and Back Pain: a Narrative Review

Pathological fractures of the spine in children (review of the literature and clinical and morphological monocenter cohort analysis)

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