Spongy graphene electrode in electrochemical detection of leukemia at single-cell levels

Akhavan, Omid; Ghaderi, Elham; Rahighi, Reza; Abdolahad, Mohammad

doi:10.1016/j.carbon.2014.08.058

Cited by 108 publications

(42 citation statements)

References 56 publications

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“…Most of the studies [15,29,49,71,119,144,147,153,154] have reported that electrophoretically deposited GRM sheets lie parallel to the surface of their underlying electrode which produce a flat surface morphology. However, several studies [39,68,91,103,105,106,136,146,155,156] have reported the EPD of GRM sheets to occur with a perpendicular or random orientation to the electrode surface, leading to a rough surface with protruding graphene edges. Orientation may relate to dynamic effects during electrophoresis, including specific effects of charging salts (see Section 6.2 (v)), but is probably also strongly influenced by capillary effects during drying, and hence, the solvent surface tension and drying method.…”

Section: Wrinkles Surface Roughness and Graphene Edgesmentioning

confidence: 99%

Electrophoretic deposition of graphene-related materials: A review of the fundamentals

Diba

Fam

Boccaccını

et al. 2016

Progress in Materials Science

223

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The Electrophoretic Deposition (EPD) of graphene-related materials (GRM) is an attractive strategy for a wide range of applications. This review paper provides an overview of the fundamentals and specific technical aspects of this approach, highlighting its advantages and limitations. Since obtaining a stable dispersion of charged particles is a pre-requisite for successful EPD, the strategies for suspending GRM in different media are discussed, along with the resulting influence on the deposited film. Most importantly, the kinetics involved in the EPD of GRMs and the factors that cause deviation from linearity in Hamaker's Law are reviewed. Side reactions often influence both efficiency and the nature of the deposited material; examples include the reduction of graphene oxide (GO) and related materials, as well as the decomposition of the suspension medium at high potentials. The microstructural characteristics of GRM deposits, and their degree of reduction, strongly influence their performance in their intended function. These factors will also determine, to a large extent, the commercial potential of this technique for applications involving GRM, and are therefore discussed here.

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Section: Wrinkles Surface Roughness and Graphene Edgesmentioning

confidence: 99%

Electrophoretic deposition of graphene-related materials: A review of the fundamentals

Diba

Fam

Boccaccını

et al. 2016

Progress in Materials Science

223

View full text Add to dashboard Cite

show abstract

“…Hence, graphene has promisingly been used in a broad range of nanotechnology-based bio-applications including DNA/RNA extractions [6,7], extremely sensitive biosensing [8], disease diagnosis [9,10], drug delivery [11,12], anti-bacterial [13][14][15], parasitical [16] and viral [17] intentions, effective cancer cell targeting, imaging and therapy [18][19][20][21][22][23], and altering the genetic characteristics of spermatozoa [24] and stem cells [25]. Recently, graphene layers have successfully been utilized in upcoming stem cell-based tissue engineering as 2D-scaffolds [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Rolled graphene oxide foams as three-dimensional scaffolds for growth of neural fibers using electrical stimulation of stem cells

Akhavan

Ghaderi²,

Shirazian

et al. 2016

Carbon

Self Cite

204

136

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“…Additionally, CNTs can exhibit electrical behavior as a metal or a semiconductor, and have large specific surface area, structural robustness, excellent electro-catalytic activity and high stability, which made them useful for potential applications in the field of chemistry, biochemistry, chemical engineering, etc. [18][19][20]. Also, CNT have been widely applied to fabricate the biosensors with the aim to improve their performance [21].…”

Section: Introductionmentioning

confidence: 99%

Application of a sensitive nanocomposite-based electrochemical sensor for voltammetric determination of dicyclomine hydrochloride in real samples

2016

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antispasmodic and anticholinergic drug, a medication that reduces the effect of acetylcholine on smooth muscles. DcCl is used to treat or prevent spasms in the muscles of the gastrointestinal tract in the irritable bowel syndrome [1,2]. DcCl has been determined by several techniques including spectrophotometry, gas chromatography and NMR spectroscopy [3][4][5][6][7]. However, most of these methods have some disadvantages such as expensive equipment, involve the use of complex procedures and long analysis times. These disadvantages make them unsuitable for routine analysis. Electrochemical techniques with excellent merits of rapid response and simple operation have attracted a lot of interest in the detection of biomolecules [8][9][10][11].Modified electrodes are being used frequently in the voltammetric determination of organic and inorganic compounds because of their efficiency and the selectivity that can be obtained by varying the modifier [12][13][14][15]. The application of nanoparticles in various fields of science and technology has been extensively developed due to the unique properties of these materials. These materials are being employed in electrochemistry to improve the performance of electrochemical techniques due to excellent electrocatalytic properties. There is currently an intense interest in the use of nanoparticles for the fabrication of modified electrodes and a wide range of bioscience applications. The fabrication of electrodes modified with nanoparticles has been the focus of recent attention owing to enhancement of the response signal, increased sensitivity and better reproducibility [12,16].Carbon-based nanostructures such as carbon nanofibers, carbon nanotubes (CNTs), and mesoporous carbons have been extensively used in fabrication of modified electrodes for applications in both analytical and industrial electrochemistry, because in addition to their low price, they exhibit suitable electrocatalytic activity for a variety Abstract In the present study a glassy carbon electrode, modified with nanocomposite of gold nanoparticles/multiwalled carbon nanotubes (GNPs/MWCNTs/GCE), was used for determination of dicyclomine hydrochloride (DcCl). The results showed that synergetic effects of GNPs and MWCNTs highly improved electrochemical response and sensitivity of the sensor. The electrochemical oxidation of DcCl was investigated by cyclic voltammetry and differential pulse voltammetry. Also, scanning electron microscopy and energy dispersive x-ray spectroscopy were used to evaluate microstructure of electrochemical sensor. The effect of various experimental parameters including pH and scan rate on the voltammetric response of DcCl were investigated. Under the optimal conditions linear response was observed in range of 1.0-1.2 × 10 2 µmol L −1 for DcCl. The lower detection limit was found to be 0.40 µmol L −1 for DcCl. The investigated method showed good stability, reproducibility and repeatability. The proposed sensor was successfully applied to the determination of DcCl in real samples.

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Spongy graphene electrode in electrochemical detection of leukemia at single-cell levels

Cited by 108 publications

References 56 publications

Electrophoretic deposition of graphene-related materials: A review of the fundamentals

Electrophoretic deposition of graphene-related materials: A review of the fundamentals

Rolled graphene oxide foams as three-dimensional scaffolds for growth of neural fibers using electrical stimulation of stem cells

Application of a sensitive nanocomposite-based electrochemical sensor for voltammetric determination of dicyclomine hydrochloride in real samples

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