“…In the 19th century, due to the good biocompatibility of sponge skeletons, which can act as a support for young vessels, scientists attempted to use commercial sponge scaffolds as a tissue replacement material in the treatment of extensive wounds and swelling [ 22 , 26 , 32 ]. This process, called sponge-grafting, involved replacement of the wound with a skeleton fragment of an appropriate shape, as a porous substrate for granulating the tissue, until it was completely covered by the epidermis (see for example Hamilton, 1881; Ferguson 1882; Sanctuary 1882; Case 1883; Kendal 1883; Burnett 1885; Acland 1888) [ 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. However, problems with the sterilization of sponge skeletons and the very slow or unsuccessful rehabilitation of destroyed tissues led to the abandonment of studies on the use of commercial sponge scaffolds as a filling in tissue defects [ 40 ].…”