The mid-nonlinearity temporal inversion (MNTI) technology based on optical phase conjugate (OPC) is firstly proposed to compensate the chromatic dispersion and nonlinearity effect of the fiber link in coherent optical orthogonal frequency division multiplexing (CO-OFDM) system. System performance is analyzed under different transmission distance and different dispersion coefficient of fiber link. Simulation results show that, compared with mid-span spectral inversion (MSSI) method, at least 2-dB Q-factor improvement is achieved for the CO-OFDM system.