Split-type assay for wide-range sensitive sensing of ochratoxin A with praseodymia nanorods

Jiang, Lei; Han, Yaning; Li, Youxun; Li, Zhuang; Zhang, Shuyuan; Zhu, Xiudong; Liu, Zhibin; Chen, Yuxue; Fernández-García, Susana; Tang, Yongjiao; Chen, Xiaowei

doi:10.1016/j.colsurfa.2022.129804

Cited by 2 publications

(4 citation statements)

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“…The mechanism of NTP affecting Pr 6 O 11 NRs in oxidizing ABTS was probably due to the coordination and hydrolysis of NTP on Pr 6 O 11 (Figure e). Due to the high oxygen mobility of Pr 6 O 11 , , as well as abundant defects on the nanorod surface, including oxygen vacancies and Pr 3+ /Pr 4+ , Pr 6 O 11 was able to catalyze the oxidation of ABTS efficiently. , It is well known that attachment of nucleic acids can modulate functionalities of nanozymes such as Fe 3 O 4 , CeO 2 , etc. , Many mechanisms, sometimes seemingly contradictory, have been proposed to account for the effects of nucleic acid on tuning oxidase-like activities . Here, we believe the boosting effect of NTP was due to its hydrolysis on Pr 6 O 11 NRs and the consequential free energy release (Δ G ) from it (Figure e).…”

Section: Resultsmentioning

confidence: 86%

“…Due to the high oxygen mobility of Pr 6 O 11 , 17,18 as well as abundant defects on the nanorod surface, including oxygen vacancies and Pr 3+ /Pr 4+ , Pr 6 O 11 was able to catalyze the oxidation of ABTS efficiently. 19,27 It is well known that attachment of nucleic acids can modulate functionalities of nanozymes such as Fe 3 O 4 , CeO 2 , etc. 28,29 Many mechanisms, sometimes seemingly contradictory, have been proposed to account for the effects of nucleic acid on tuning oxidase-like activities.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Colorimetric sensing is a sensitive, cost-effective analytical method . Development of nanozymes, i.e ., biomimetic enzymes, has demonstrated great potential in replacing natural enzymes in colorimetric analysis, including CeO 2 , Fe 3 O 4 , Au, and metal–organic frameworks. − Praseodymia (Pr 6 O 11 ) has excellent oxygen mobility and unique semiconductor electrical behavior. , Pr 6 O 11 nanorods (NRs) were recently reported to exhibit high oxidase-like activity . Herein, we develop a simple colorimetric method to detect PIK3CA mutation SNP based on distinctive influences of nucleoside triphosphates (NTPs) on tuning the oxidase-mimicking activity of Pr 6 O 11 NRs.…”

Section: Introductionmentioning

confidence: 99%

“…17,18 Pr 6 O 11 nanorods (NRs) were recently reported to exhibit high oxidase-like activity. 19 Herein, we develop a simple colorimetric method to detect PIK3CA mutation SNP based on distinctive influences of nucleoside triphosphates (NTPs) on tuning the oxidase-mimicking activity of Pr 6 O 11 NRs. By establishing the "fingerprint profiles" of each NTP, this method could indicate whether there is a mutation in the PIK3CA genes.…”

Section: ■ Introductionmentioning

confidence: 99%

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Enzyme-Free Colorimetric Method for Fast Detection of PIK3CA Gene Mutation by Praseodymia Nanorods

Jiang

Wang

et al. 2023

Anal. Chem.

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The frequently mutated phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) gene is associated with multiple tumors and endocytosis of viruses. Identification of muted nucleotides at the hotspot can help in finding the susceptible people who are vulnerable to cancers and viruses. Herein, a simple enzyme-free colorimetric method is developed for the quick detection of PIK3CA gene mutations. The main mechanism lies in the dissimilar interactions between praseodymia nanorods and different nucleotides, as well as the underlying oxidase-mimicking characteristics of praseodymia. With rational designs of probes and processes, this method has great potential for expanded applications in the screening of mutations in other genes of interest.

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