The frequently mutated phosphatidylinositol 3-kinase
catalytic
subunit alpha (PIK3CA) gene is associated with multiple tumors and
endocytosis of viruses. Identification of muted nucleotides at the
hotspot can help in finding the susceptible people who are vulnerable
to cancers and viruses. Herein, a simple enzyme-free colorimetric
method is developed for the quick detection of PIK3CA gene mutations.
The main mechanism lies in the dissimilar interactions between praseodymia
nanorods and different nucleotides, as well as the underlying oxidase-mimicking
characteristics of praseodymia. With rational designs of probes and
processes, this method has great potential for expanded applications
in the screening of mutations in other genes of interest.
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