2017
DOI: 10.1097/gox.0000000000001595
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Split Tolerance in a Murine Model of Heterotopic En Bloc Chest Wall Transplantation

Abstract: Background:Congenital and acquired chest wall deformities represent a significant challenge to functional reconstruction and may impact feasibility of heart transplantation for patients with end-stage organ failure. In the recent past, the concept of replacing like-with-like tissue by using vascularized composite allografts (VCA) has been enthusiastically employed for reconstruction of complex tissue defects.Methods:In this study, we introduce a novel murine model for en bloc chest wall, heart, and thymus tran… Show more

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Cited by 5 publications
(3 citation statements)
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“…The heterogeneous structure of the chest wall, including soft tissue, cartilage and bone, demands for materials allowing the reconstruction of tissues with a wide range of stiffness, topography and composition. A viable option is to use vascularized composite allografts 36 , but also the application of cell-free grafts derived from different tissues is suitable. Due to its integrative and flexible properties, dermis had been successfully applied to close thoracic wall defects.…”
Section: Discussionmentioning
confidence: 99%
“…The heterogeneous structure of the chest wall, including soft tissue, cartilage and bone, demands for materials allowing the reconstruction of tissues with a wide range of stiffness, topography and composition. A viable option is to use vascularized composite allografts 36 , but also the application of cell-free grafts derived from different tissues is suitable. Due to its integrative and flexible properties, dermis had been successfully applied to close thoracic wall defects.…”
Section: Discussionmentioning
confidence: 99%
“…The immune modulatory regimes were chosen based on previous reports of successful immune modulation and neuroprotective property 11 , 17 , 39 41 .…”
Section: Methodsmentioning
confidence: 99%
“…Combining this method with concepts from the vascularized hind-limb transplant as a source of donor bone marrow, one variation of the en bloc method included en bloc heart, thymus, and chest wall. 27 Mice who received these extensive en bloc transplants also showed prolonged survival off immunosuppression. Survival was augmented by the addition of costimulation blockade with anti-CD154 antibodies.…”
Section: Thymic Interventionmentioning
confidence: 99%