Split‐dose versus day‐before regimen of sodium picosulfate plus magnesium citrate for bowel cleansing before colonoscopy in children: Randomized controlled trial

Abstract

Objectives: Polyethylene glycol (PEG) split-dose regimen is recommended as the option of choice for colon preparation before colonoscopy in children and adults. Sodium picosulfate plus magnesium citrate (SPMC) is equally effective but better tolerated than PEG for bowel preparation before colonoscopy in children. The aim of this study was to assess the superiority of SPMC split-dose regimen compared with SPMC day-before regimen for bowel cleansing before colonoscopy in children. Methods:This was a multicenter, randomized, single-blind study. Pediatric inpatients undergoing colonoscopy received SPMC either in the day-before dosing or in split dosing. Overall bowel cleansing was assessed using the Boston Bowel Preparation Scale (BBPS) and was rated as successful when BBPS was ≥6. Patient tolerability, acceptability, and compliance were recorded. Results:The rate of successful cleansing level was significantly higher in the split-dose group than in the day-before group (P < 0.001). The BBPS scores were significantly higher in the split-dose group than in the day-before group for the whole colon (P < 0.001), the right colon (P < 0.001) and transverse colon (P < 0.001). Patient acceptability was better in the splitdose group (P = 0.0003; P = 0.005). The percentage of children needing nasogastric tube placement was better in the split-dose group (P = 0.007). Conclusions:The split-dose regimen of SPMC was superior to the day-before regimen in terms of successful colon cleansing and acceptability.

Bowel preparation for pediatric colonoscopy: Which regimen is the best?

“…This study also demonstrated that the PMC regimen tended to show an improved tolerability (including the need for nasogastric tube), acceptability, and compliance compared with other day-before PEG regimens. According to their studies, 6,8 split-dose PMC appears to be the most suitable regimen because of its improved tolerability. However, no study has yet compared split-dose PMC and split-dose PEG regimens in pediatric colonoscopy.…”

“…In this issue of Digestive Endoscopy , Di Nardo et al 8 . reported the efficacy of the PMC split‐dose regimen for pediatric colonoscopy.…”