Splenic metastasis arising from recurrent nasopharyngeal carcinoma: A rare case report

Abu‐Zaid, Ahmed; Qureshi, Sarah; Mina, Syeda; Y, Safwat; Sulaimanie, Shrouq; Azzam, Ayman; Mohammed, Shamayel; Amin, Tarek

doi:10.4103/0377-4929.155350

Cited by 1 publication

(6 citation statements)

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“…Among the 15 selected studies [ 3 , 5 , 27 – 39 ] reporting on splenic metastases from NPC, 13 were published between 2000 and 2015, one was published in 1989, and one was published in 1952. The included studies were very heterogeneous in their design, aims and methods.…”

Section: Systematic Review Of the Literaturementioning

confidence: 99%

“…The included studies were very heterogeneous in their design, aims and methods. There were three case reports [ 27 , 36 , 38 ] and 12 case series [ 3 , 5 , 28 - 35 , 37 , 39 ]. The studies focused on NPC and the imaging techniques used for diagnosis ( n = 5) [ 28 , 33 , 35 , 37 , 39 ], splenic metastases from solid tumors ( n = 3) [ 3 , 5 , 31 ], experience of a single institution in NPC treatment ( n = 2) [ 30 , 34 ], use of serum markers in monitoring NPC systemic relapse ( n = 1) [ 29 ], and chemotherapy in NPC patients ( n = 1) [ 32 ].…”

Section: Systematic Review Of the Literaturementioning

confidence: 99%

“…The studies focused on NPC and the imaging techniques used for diagnosis ( n = 5) [ 28 , 33 , 35 , 37 , 39 ], splenic metastases from solid tumors ( n = 3) [ 3 , 5 , 31 ], experience of a single institution in NPC treatment ( n = 2) [ 30 , 34 ], use of serum markers in monitoring NPC systemic relapse ( n = 1) [ 29 ], and chemotherapy in NPC patients ( n = 1) [ 32 ]. Nine studies [ 3 , 28 , 29 , 32 – 35 , 38 , 39 ] were performed in Asian populations, three in Western countries [ 5 , 31 , 37 ], one in the Middle East [ 27 ], one in Africa [ 30 ], and one in India [ 36 ]. Overall, 25 cases of splenic metastases from NPC were described.…”

Section: Systematic Review Of the Literaturementioning

confidence: 99%

“…Solitary splenic metastases with histological confirmation were reported in three cases only [ 3 , 27 , 38 ] (Table 1 ). In particular, the case reported by Suh et al [ 38 ] had a presentation similar to our patient.…”

Section: Systematic Review Of the Literaturementioning

confidence: 99%

“…No recurrence was observed after 5 months of follow-up. Similarly, Abu-Zaid et al [ 27 ] reported the case of a young man with a history of NPC who experienced referred pain in the upper abdominal quadrant. A splenic lesion was detected by means of a CT scan, and an ultrasound-guided biopsy confirmed a NPC metastasis.…”

Section: Systematic Review Of the Literaturementioning

confidence: 99%

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Solitary splenic metastasis from nasopharyngeal carcinoma: a case report and systematic review of the literature

et al. 2016

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BackgroundSolitary splenic metastases are a rare occurrence, and the nasopharyngeal carcinoma represents one of the most uncommon primary sources. The present study aimed to describe a rare case of a solitary single splenic metastasis from nasopharyngeal carcinoma and to assess the number of cases of isolated nasopharyngeal carcinoma metastases to the spleen reported in the literature.Main bodyWe describe the case of a 56-year-old man with a history of nasopharyngeal carcinoma and complete remission after chemo-radiotherapy. Three months after complete remission, positron emission tomography/computed tomography scan revealed a hypermetabolic splenic lesion without increased metabolic activity in other areas. After laparoscopic splenectomy, the pathology report confirmed a single splenic metastasis from undifferentiated carcinoma of the nasopharyngeal type. The postoperative period was uneventful. We also performed a systematic review of the literature using MEDLINE and Google Scholar databases. All articles reporting cases of splenic metastases from nasopharyngeal carcinoma, with or without histologic confirmation, were evaluated. The literature search yielded 15 relevant articles, which were very heterogeneous in their aims and methods and described only 25 cases of splenic metastases from nasopharyngeal carcinoma.ConclusionThe present review shows that solitary splenic metastases from nasopharyngeal carcinoma are a rare event, but it should be considered in patients presenting with splenic lesions at imaging and a history of primary or recurrent nasopharyngeal carcinoma. No evidence supports a negative impact of splenectomy in patients with solitary splenic metastasis from nasopharyngeal carcinoma.

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Section: Systematic Review Of the Literaturementioning

confidence: 99%