Splenic infarction related to cocaine use

Heroin-associated myocardial damages—Conventional and immunohistochemical investigations

“…The underlying process still remains unclear. There are numerous studies concerning only the influence of cocaine [1][2][3][4][5][7][8][9][10][11][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. The present study includes 21 cases of death induced by primarily morphine and/or adulterants in drug abusers, but only in 2 cases, cocaine was involved.…”

“…These infarctions indicate a cocaine-induced vascular ischemia, functional obstruction by spasms of the small vessel walls or thrombotic events [19]. However, cocaine-associated infarction and ischemic events also are described concerning the skin [20], the intestine [21][22][23], the aorta with aortic dissection [24] and the spleen [25][26][27]. Furthermore, the risk of spontaneous abortion is reported to be increased under the influence of cocaine [28].…”

Cocaine-associated abscesses with lethal sepsis after splenic infarction in an 17-year-old woman

“…Urine: benzoylecgonine 127 ng/ml. [14] Renal infarction Vaghjimal [23], Novielli et al [24] Splenic infarction Cregler et al [1], Fineshi et al [3] Myocardial infarction Nalbandian et al [19] Intestinal ischemia Zamora-Quizada et al [18] Skin infarction Gadaleta et al [22] Acute aortic dissection Heng et al [17] Thrombotic phenomenon Ness et al [25] Spontaneous abortion Brown et al [20] Ischemic colitis Daras et al [10] Neurovascular complications De Clari et al [26] Acute rhabdomyolysis Pogue et al [16] Acute myoglobinuric renal failure Dettmeyer et al (this report) Splenic infarction Fig. 3.…”

“…The spleen Forensic Science International 140 (2004) [21][22][23] weighted 610 g. Two older infarctions up to 3 cm in diameter were found and a grey-yellow 10 cm  8 cm  5 cm infarction with central necroses, suppuration and an great abscess ( Fig. 1).…”

“…These infarctions point to a cocaine-induced vascular ischemia or functional obstruction by spasms of the small vessel walls or thrombotic events [17]. However, cocaine-associated infarction and ischemic events also are described concerning the skin [18], the intestine [19][20][21], the aorta with aortic dissection [22] and the spleen [23,24]. The risk of spontaneous abortion is reported to be increased under the influence of cocaine [25].…”