Heroin-associated myocardial damages—Conventional and immunohistochemical investigations

Dettmeyer, R.; Friedrich, Karen; Schmidt, Péter; Madea, Burkhard

doi:10.1016/j.forsciint.2009.02.014

Cited by 38 publications

(32 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, chronic morphine treatment did not modify Hsp27 phosphorylation, whereas naloxone administration to morphine-dependent rats induced an enhancement of Hsp27 phosphorylation at Ser82. Altogether, these results support the idea that morphine dependence and withdrawal induce profound cellular stress that could produce myocardial damages (Dettmeyer et al, 2009).…”

Section: Discussionsupporting

confidence: 81%

“…It is known that drugs of abuse induce cardiac morphological alterations and cardiac disorders (Cerretani et al, 2008;Dettmeyer et al, 2009), but the mechanism underlying the drug-induced myocardial damage remains unclear. Therefore, the purpose of the present study was to establish some mechanisms implicated in the cardiac adaptive changes observed during morphine withdrawal.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Morphine Withdrawal Activates Hypothalamic-Pituitary-Adrenal Axis and Heat Shock Protein 27 in the Left Ventricle: The Role of Extracellular Signal-Regulated Kinase

Martínez-Laorden

Hurlé²,

Milanés³

et al. 2012

J Pharmacol Exp Ther

View full text Add to dashboard Cite

The negative affective states of withdrawal involve the recruitment of brain and peripheral stress circuitry [e.g., noradrenergic activity, induction of the hypothalamo-pituitary-adrenocortical (HPA) axis, and the expression and activation of heat shock proteins (Hsps)]. The present study investigated the role of extracellular signal-regulated protein kinase (ERK) and ␤-adrenoceptor on the response of stress systems to morphine withdrawal by the administration of [amino[(4-aminophenyl)thio] methylene]-2-(trifluoromethyl)benzeneacetonitrile (SL327), a selective inhibitor of ERK activation, or propranolol (a ␤-adrenoceptor antagonist). Dependence on morphine was induced by a 7-day subcutaneous implantation of morphine pellets. Morphine withdrawal was precipitated on day 8 by the injection of naloxone (2 mg/kg s.c.). Plasma concentrations of adrenocorticotropin and corticosterone were determined by radioimmunoassay; noradrenaline (NA) turnover in left ventricle was determined by high-performance liquid chromatography; and catechol-O-methyl transferase (COMT) and Hsp27 expression and phosphorylation at Ser82 were determined by quantitative blot immunolabeling. Morphine-withdrawn rats showed an increase of NA turnover and COMT expression in parallel with an enhancement of adrenocorticotropin and plasma corticosterone concentrations. In addition, we observed an enhancement of Hsp27 expression and phosphorylation. Pretreatment with SL327 or propranolol significantly reduced morphine withdrawal-induced increases of plasma adrenocorticotropin and Hsp27 phosphorylation at Ser82 without any changes in plasma corticosterone levels. The present findings demonstrate that morphine withdrawal is capable of inducing the activation of HPA axis in parallel with an enhancement of Hsp27 expression and Hsp27 phosphorylation at Ser82 and suggest a role for ␤-adrenoceptors and ERK pathways in mediating morphine-withdrawal activation of the HPA axis and cellular stress response.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Morphine Withdrawal Activates Hypothalamic-Pituitary-Adrenal Axis and Heat Shock Protein 27 in the Left Ventricle: The Role of Extracellular Signal-Regulated Kinase

Martínez-Laorden

Hurlé²,

Milanés³

et al. 2012

J Pharmacol Exp Ther

View full text Add to dashboard Cite

show abstract

“…The results of this study showed that 4% of abusers had mild increase in hematocrite level and 2% of narcotic drugs abusers had mild lower level of blood sugars than normal range, and 4% of participants had increase liver enzymes such ALT (alanine transferase), AST (aspartat transferase), ALP (alkaline phosphatease) and 1% of them had renal failure. Although blood level BUN (Blood Urea Nitrogen) and creatinin were examined to evaluation of their renal failure [11,12,22]. Fig.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Abuse Drugs and Clinical Laboratory Tests Variations in Whole Blood & Urine Samples of Abusers

Basiri¹,

Behshid²,

Najafi³

et al. 2018

JPP

View full text Add to dashboard Cite

Abstract:In this study, five hundred urine samples and five hundred blood samples of abusers were examined for the presence of alkaloid substances and abuse drugs in urines and bloods. These numbers of blood and urine samples of addicts in clinics of welfare organization, during detoxification treatment or maintenance treatment were screened for abuse drugs presence. The all of samples were tested through as a view of clinical laboratory methods. Age ranges of female patients were 35 ± 15 and age range of males patients were 45 ± 15. All patients filled questionnaire and satisfy forms too. First, all fresh urine and blood samples were examined to confirm presence drugs abuses, depend on their addiction and treatment, so all samples were confirmed by two tests. Then they were examined to other clinical laboratory tests. All data were analyzed by t-test and were Anova one way and two ways of Anova Turkey, and p < 0.05 was considered significant. The p-value of this study was p = 0.0001. The results of this study were showed that 4% of abusers had mild increase in hematocrite level and 2% of narcotic drugs abusers had mild lower level of blood sugars than normal range and 4% of participants had increase liver enzymes such ALT (alanine transferase), AST (aspartat transferase), ALP (alkaline phosphatease) and 1% of them had renal failure. Although blood level BUN (blood urea nitrogen) and creatinin were examined to evaluation of their renal failure .The results in Tabriz/Iran undrevision of welfare organization clinics were approximately showed that positive results of addiction are in each of urine and blood samples. Because some of abusers directly consumed full long time agonist or partial agonists' drugs such as methadone and buprenorphine for their maintenance therapy in clinics. Also doing test on blood samples has high importance in distinguishing and confirmation of drugs abuse in samples. Also in this study we conclude that among all drug analytical methods the cheapest and easiest test to screening opioids and other abuse drugs in urine and blood samples is strip test for rapid diagnosis, also tests on blood samples have high importance as a view point of accuracy to distinguishing of drugs abuse, and serum levels of some other parameters showed all abusers patients situation such as liver and renal dysfunction through clinical laboratory tests.

show abstract

“…También se ha reportado miocarditis con infiltrados leucocitarios insterticial en 21 personas adictas a opiáceos parenterales que fallecieron. Estas células eran cinco veces más abundantes en los cadáveres de los adictos que en los fallecidos por otras causas como el trauma 35 .…”

Section: Dependencia a Opiáceosunclassified

Complicaciones del uso de la heroína parenteral: artículo de revisión

Ocampo

Gómez

2017

MedUPB

View full text Add to dashboard Cite

RESUMENRevisión narrativa que buscó recopilar informacion sobre complicaciones del uso de la heroína parenteral. Fueron captados artículos científicos, revisiones y casos clínicos en las bases de datos Scielo, Lilacs, Medline. La heroína es una sustancia psicoactiva y su uso tiene consecuencias adversas para la salud física y mental; las complicaciones físicas más frecuentes son infecciones por virus como el HIV, las hepatitis B y C, infecciones de piel, tuberculosis, embolias pulmonares y enfermedades renales. Otras complicaciones frecuentes son los trastornos mentales como depresión, trastornos de personalidad y el uso concomitante de otras sustancias, como el cannabis y la cocaína. Para el profesional de enfermería es importante conocer las complicaciones del uso de la heroína para planear procesos integrales y elaborar programas de reduccion de riesgos y daños derivados del uso de la sustancia. Palabras clave: heroína; abuso de sustancias por vía intravenosa; impactos en la salud. ABSTRACTThis literature review sought to collect information on complications of parenteral use of heroin. Scientific articles, reviews, and case reports were selected from Scielo, Lilacs, and Medline databases. Heroin is a psychoactive substance and its use has mental and physical health consequences; among the most common physical consequences are blood-borne infectious diseases such as HIV, hepatitis B and C, skin infections, tuberculosis, pulmonary embolism, and renal disease. Other frequent complications include mental disorders, such as depression, personality disorders, and the concomitant abuse of other substances, such as cannabis and cocaine. It is important for nurses to be aware of the complications of heroin use in order to plan comprehensive processes and develop nursing programs that reduce the risks and harm resulting from use of the substance. Keywords: heroin; substance abuse, intravenous; impacts on health. RESUMORevisão narrativa que buscou recopilar informação sobre complicações do uso da heroína parenteral. Foram captados artigos científicos, revisões e casos clínicos nas bases de dados Scielo, Lilacs, Medline. A heroína é uma substância psicoativa e seu uso tem consequências adversas para a saúde física e mental; as complicações físicas mais frequentes são infecções por vírus como o HIV, as hepatite B e C, infecções da pele, tuberculose, embolias pulmonares e doenças renais. Outras complicações frequentes são os transtornos mentais como depressão, transtornos de personalidade e o uso concomitante de outras substâncias, como a maconha e a cocaína. Para o profissional de enfermagem é importante conhecer as complicações do uso da heroína para planejar processos integrais e elaborar programas de redução de riscos e estragos derivados do uso da substância. Palavras chave: heroína; abuso de substâncias por via intravenosa; impactos na saúde.

show abstract

Heroin-associated myocardial damages—Conventional and immunohistochemical investigations

Cited by 38 publications

References 37 publications

Morphine Withdrawal Activates Hypothalamic-Pituitary-Adrenal Axis and Heat Shock Protein 27 in the Left Ventricle: The Role of Extracellular Signal-Regulated Kinase

Morphine Withdrawal Activates Hypothalamic-Pituitary-Adrenal Axis and Heat Shock Protein 27 in the Left Ventricle: The Role of Extracellular Signal-Regulated Kinase

Evaluation of Abuse Drugs and Clinical Laboratory Tests Variations in Whole Blood & Urine Samples of Abusers

Complicaciones del uso de la heroína parenteral: artículo de revisión

Contact Info

Product

Resources

About