Splenic Infarct and Pulmonary Embolism as a Rare Manifestation of Cytomegalovirus Infection

Rawla, Prashanth; Vellipuram, Anantha; Bandaru, Sathyajit S.; Raj, Jeffrey Pradeep

doi:10.1155/2017/1850821

Cited by 7 publications

(9 citation statements)

References 9 publications

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“…Initially, empirical treatment for meningitis was initiated because of the clinical picture; however, the antibiotics and antiviral treatments were discontinued with the diagnosis of CMV infection. Acute CMV infection and splenic infarction are rare in immunocompetent patients, and only a few case reports have been reported in the literature [ 2 , 3 , 4 , 5 ]. The exact pathophysiological mechanism by which CMV infection triggers thrombosis is unclear.…”

Section: Discussionmentioning

confidence: 99%

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Cytomegalovirus-Associated Splenic Infarction in a Young Female Patient

Pakkiyaretnam

Horne

Sarr

et al. 2020

Cureus

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Cytomegalovirus (CMV) infection generally causes asymptomatic infection in the majority of immunocompetent individuals. However, the presentation may be complicated by life-threatening conditions in immunocompromised patients. We report a case of a 23-year-old healthy Caucasian female with acute CMV infection and splenic infarction. Serological studies confirmed acute CMV infection, and echocardiography did not show any evidence of endocarditis or mural thrombosis. We did not consider antiviral and anticoagulation therapies due to the immunocompetent nature of the patient and since the condition was suspected to be a minor vessel disease likely triggered by CMV infection.

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Section: Discussionmentioning

confidence: 99%

“…Serious complications of vasculopathy and thrombosis associated with CMV infection have been reported extensively in immunocompromised patients [ 2 ]. However, splenic infarction in immunocompetent patients is uncommon [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus-Associated Splenic Infarction in a Young Female Patient

Pakkiyaretnam

Horne

Sarr

et al. 2020

Cureus

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“…The absence of communication on imaging with the pancreatic duct helps in the differentiation of MCN and SCN from IPMN [56]. Needle-based confocal laser endomicroscopy (nCLE) is an emerging imaging technique performed during EUS-FNA and provides real-time images of the internal structure of the pancreatic cyst [57][58][59]. In the CONTACT study by Napoléon et al, a superficial vascular network pattern was used to identify SCA with a sensitivity of 69%, a specificity of 100%, positive predictive value of 100%, negative predictive value of 82%, and accuracy of 87%.…”

Section: Serous Cystic Tumours (Scn)mentioning

confidence: 99%

An updated review of pancreatic cystic lesions

Muralidharan¹,

Raj²,

Nathala³

2019

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A pancreatic cystic lesion (PCL) is a collection of fluid in the pancreas, which is often diagnosed incidentally during abdominal imaging, and often poses a diagnostic and therapeutic challenge. PCLs not only have diverse histological and imaging appearances but also differ in clinical presentation, biologic behaviour, growth pattern, and risk of malignancy. Apart from their diagnosis, the management of PCL is also multifactorial, which takes into consideration risk of malignancy, cost of cyst analysis, cyst surveillance, anatomic location of the cyst, the patient's age, and overall health status. Although guidelines exist for surgical and conservative management, each case needs to be tailored to malignant risk, surgical risk, and life expectancy in mind. This would thereby reduce both the monetary and non-monetary burden on patients. In this review, we aim to provide insight into the various recent advances in the diagnosis and management of PCL. Streszczenie Zmiana torbielowata w trzustce (PCL) to zbiornik płynu, który często jest diagnozowany przypadkowo podczas obrazowania jamy brzusznej. Nierzadko stanowi on wyzwanie diagnostyczne i terapeutyczne. Zmiany torbielowate różnią się między sobą wynikami badań histologicznych i obrazowych, a także obrazem klinicznym, cechami biologicznymi, wzorcem wzrostu i ryzykiem nowotworu. Postępowanie w PCL jest wieloczynnikowe, uwzględnia ryzyko złośliwości, koszty analizy torbieli, kontrolę nad torbielą, jej lokalizację anatomiczną, wiek i ogólny stan zdrowia pacjenta. Chociaż istnieją wytyczne dotyczące postępowania chirurgicznego i zachowawczego, każdy przypadek musi być rozpatrywany indywidualnie z uwzględnieniem ryzyka złośliwości, ryzyka chirurgicznego i średniej długości życia. W ten sposób zmniejszyłoby się obciążenie pacjentów-zarówno finansowe, jak i innego rodzaju. Autorzy przedstawiają najnowsze informacje dotyczące postępów w diagnostyce i leczeniu PCL.

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“…Symptomatic venous thromboembolism occurs in 1-2 per 1000 adults each year, with about a third presenting with PE [49]. Some of the risk factors include age, previous thromboembolism, malignancy, coagulation disorders, and oral contraception [50,51]. The risk of developing symptomatic PE is sevenfold higher in patients with cancer than in those without, and approximately 10% of all PEs are secondary to known cancer [52].…”

Section: Pulmonary Embolismmentioning

confidence: 99%

“…Diagnostic modalities for studying haemoptysis include CXR, bronchoscopy, multi-detector computed tomography (MDCT), MDCT angiography (MDCTA), and DSA [51]. Management of patients with haemoptysis is based on the rate and severity of bleeding and the clinical condition of the patient [61].…”

Section: Massive Haemoptysis and Diffuse Alveolar Haemorrhage (Dah)mentioning

confidence: 99%

Comprehensive review of oncological emergencies seen in clinical practice

Oben¹,

Fein²

2019

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Aim of the research: To provide an up-to-date review of the literature on the pathophysiology, diagnosis, and management of common oncologic emergencies encountered in clinical practice. Material and methods: We conducted a systematic computerised search in PubMed, Scopus, Web of Science, and Embase. Results: We reviewed relevant medical literature. Most common complications requiring emergency management are addressed in this review, specifically: tumour lysis syndrome, seizures and status epilepticus, pulmonary embolism, leukostasis, thrombotic microangiopathy, febrile neutropaenia, disseminated intravascular coagulation, massive haemoptysis, diffuse alveolar haemorrhage, stem cell transplant-related complications, surgically related complications of malignancy, metastatic spinal cord metastasis, and superior vena cava syndrome. Conclusions: Oncologic emergencies and related complications demand increased attention from attending physicians, oncologists, and intensivists. Knowledge of oncologic emergencies encountered in clinical practice expedites the ability of physicians to manage them properly. The identification and institution of proper management can improve outcomes in these patients. Streszczenie Cel pracy: Przegląd aktualnego piśmiennictwa na temat patofizjologii, diagnostyki i postępowania w nagłych przypadkach onkologicznych w praktyce klinicznej. Materiał i metody: Przeprowadzono systematyczne, komputerowe wyszukiwanie przypadków onkologicznych w bazach PubMed, Scopus, Web of Science i Embase. Wyniki: Dokonano przeglądu odpowiedniej literatury medycznej. W pracy omówiono najczęściej występujące powikłania wymagające pilnego leczenia, takie jak zespół rozpadu guza, napady i stan padaczkowy, zatorowość płucna, leukostaza, mikroangiopatia zakrzepowa, gorączka neutropeniczna, zespół rozsianego wykrzepiania wewnątrznaczyniowego, masywne krwioplucie, rozlane krwawienie pęcherzykowe, powikłania związane z przeszczepem komórek macierzystych, powikłania chirurgiczne związane z nowotworem, przerzuty do rdzenia kręgowego i zespół żyły głównej górnej. Wnioski: Nagłe przypadki onkologiczne oraz związane z nimi powikłania wymagają większej uwagi lekarzy prowadzących, onkologów i lekarzy intensywnej terapii. Znajomość nagłych przypadków onkologicznych spotykanych w praktyce klinicznej pozwala na sprawne ich leczenie. Ustalenie oraz wdrożenie właściwego postępowania umożliwia poprawę wyników leczenia tych chorych.

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Splenic Infarct and Pulmonary Embolism as a Rare Manifestation of Cytomegalovirus Infection

Cited by 7 publications

References 9 publications

Cytomegalovirus-Associated Splenic Infarction in a Young Female Patient

Cytomegalovirus-Associated Splenic Infarction in a Young Female Patient

An updated review of pancreatic cystic lesions

Comprehensive review of oncological emergencies seen in clinical practice

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