Splenic Imaging with Ultrasmall Superparamagnetic Iron Oxide Ferumoxtran-10 (AMI-7227): Preliminary Observations

Harisinghani, Mukesh G.; Saini, Sanjay; Weissleder, Ralph; Rubin, Daniel L.; DeLange, E. E.; Harms, S.E.; Weinreb, J. C.; Small, William; Sukerkar, Arun N.; Brown, J J; Zelch, James V.; Lucas, Maria; Morris, Marie; Hahn, Peter F.

doi:10.1097/00004728-200109000-00017

Cited by 20 publications

(9 citation statements)

References 26 publications

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“…In this case each mouse received 300 μg of MION particles, onto which 120 μg of Aβ1‐40 was adsorbed (as described above, corresponding to 190 mg Fe/kg). The dosage of MION reported in human studies has ranged between 1.1 and 2.6 mg Fe/kg (23–26); hence, the mice received a substantially higher dose. Immediately before the MION‐Aβ1‐40 was injected into the common carotid artery, it was mixed with 600 μl of 15% mannitol in PBS.…”

Section: Methodsmentioning

confidence: 99%

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

Wadghiri

Sigurdsson

Sadowski

et al. 2003

Magnetic Resonance in Med

254

201

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Section: Methodsmentioning

confidence: 99%

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

Wadghiri

Sigurdsson

Sadowski

et al. 2003

Magnetic Resonance in Med

254

201

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“…Ferumoxtran‐10 has been investigated as a contrast agent for imaging the liver and spleen. Intravenous Ferumoxtran‐10 injection results in prolonged T2*‐weighted negative enhancement in rat liver (31) and improves contrast for detecting focal splenic lesions (19). We obtained similar results after intraperitoneal injection.…”

Section: Discussionmentioning

confidence: 99%

“…Ferumoxtran‐10 also labels the RES in the liver (18), spleen (19), and bone marrow (20, 21). In neonates, MRI is being increasingly used to evaluate the prognosis of brain lesions, usually at the stage of irreversible damage.…”

mentioning

confidence: 99%

USPIO (Ferumoxtran‐10)‐enhanced MRI to visualize reticuloendothelial system cells in neonatal rats: Feasibility and biodistribution study

Azoulay

Olivier

Baud

et al. 2008

Magnetic Resonance Imaging

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PurposeTo investigate whether USPIO‐enhanced magnetic resonance imaging (MRI) detected reticuloendothelial system (RES) cells in newborn normal rats.Materials and MethodsNewborn normal rats were imaged in vivo on a 1.5 T MR system, 2–96 hours after intraperitoneal Ferumoxtran‐10 (n = 38) or saline injection (control group, n = 5). Signals from liver, spleen, and vertebral bone marrow were measured (T2‐weighted Turbo Spin Echo) to describe the kinetics of enhancement. The pups were sacrificed and iron concentrations in plasma and peritoneal fluid were measured using atomic absorption spectrometry. Prussian blue‐labeled cells density in liver, spleen, and vertebral bone marrow was assessed.ResultsSignificant (P < 0.05) negative enhancement of the liver, spleen, and vertebral bone marrow was noted after Ferumoxtran‐10 injection (2–96 hours for liver and spleen, 4–96 hours for bone marrow). Ferumoxtran‐10 was absorbed from the peritoneum in the first 8 hours postinjection, entering the circulation with a plasma peak (8 hours); then Ferumoxtran‐10 returned over the baseline in plasma (96 hours). Important intracellular iron deposition in liver and spleen was measured postinjection (3–96 hours, P < 0.05). Limited but significant intracellular iron deposition was noted in vertebral bone marrow postinjection (96 hours, P < 0.05), suggesting that Ferumoxtran‐10 selectively labeled RES cells after 96 hours and produced nonspecific labeling at earlier timepoints.ConclusionFerumoxtran‐10‐enhanced MRI visualizes RES cells in vivo in newborn rats. J. Magn. Reson. Imaging 2008;28:1046–1052. © 2008 Wiley‐Liss, Inc.

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“…This method is particularly useful for detecting locoregional metastases that do not produce an overall increase in lymph node size, that is, clinically 'occult' disease that is below the detection threshold of currently available imaging methods. MNPs have also been used clinically to better delineate primary tumors [33], to detect metastases [34,35], to image angiogenesis [36] and to map the vascular supply of primary tumors preoperatively. Finally, MNPs are in clinical testing to image inflammatory components of atherosclerosis [37], to assess vascular patency [38] and to image multiple sclerosis and rheumatoid arthritis.…”

Section: O 3 ] or Magnetite [Fe 3 O 4 ])mentioning

confidence: 99%

Targeted Delivery of Multifunctional Magnetic Nanoparticles

et al. 2007

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Magnetic nanoparticles and their magnetofluorescent analogues have become important tools for in vivo imaging using magnetic resonance imaging and fluorescent optical methods. A number of monodisperse magnetic nanoparticle preparations have been developed over the last decade for angiogenesis imaging, cancer staging, tracking of immune cells (monocyte/macrophage, T cells) and for molecular and cellular targeting. Phage display and data mining have enabled the procurement of novel tissue- or receptor-specific peptides, while high-throughput screening of diversity-oriented synthesis libraries has identified small molecules that permit or prevent uptake by specific cell types. Next-generation magnetic nanoparticles are expected to be truly multifunctional, incorporating therapeutic functionalities and further enhancing an already diverse repertoire of capabilities.

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Splenic Imaging with Ultrasmall Superparamagnetic Iron Oxide Ferumoxtran-10 (AMI-7227): Preliminary Observations

Abstract: Ferumoxtran-10 is a promising contrast agent for the evaluation of focal splenic lesions.

Cited by 20 publications

References 26 publications

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

USPIO (Ferumoxtran‐10)‐enhanced MRI to visualize reticuloendothelial system cells in neonatal rats: Feasibility and biodistribution study

Targeted Delivery of Multifunctional Magnetic Nanoparticles

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