Splenic hamartomas in a dog

Matos, Augusto J. F. de; Duarte, S.; Lopes, Célia; Lopes, J.M.; Gärtner, Fátima

doi:10.1136/vr.161.9.308

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…Important differential diagnoses for vascular hamartomas include, angiomatosis secondary to lymphedema and capillary hemangiomas [14,25], hemangioblastomas and these can be differentiated on the basis of histopathological features [28]. However, angiomatosis secondary to lymphedema are accompanied by characteristic hypoplasia of the deep lymphatic vessels and markedly dilated lymphatics, which were not seen in the current case.…”

Section: Discussionmentioning

confidence: 60%

“…Vascular hamartomas (VH) are non-neoplastic proliferations of vascular tissue. They are congenital defects of vascular formation and development, giving rise to normal tissue that is organized in a disorderly manner [1,2,4,10,15,18,20] and are also considered benign tumors [6,8,14,26]. VH has been recently considered neoplastic because it exhibits chromosomal aberrations that are acquired through complete somatic mutations [11].…”

Section: Discussionmentioning

confidence: 99%

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Cerebral Vascular Hamartoma In a Campeiro Bulldog

Barros¹,

Gulgemin²,

Barreto³

et al. 2020

Acta Scientiae. Vet.

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Background: Vascular hamartomas (VH) are rare or simply underdiagnosed injuries in veterinary medicine and represent a non-neoplastic developmental anomaly disorganization and proliferation of endothelial tissue. VH occur in any region of the body, however in the brain present clinical relevance related with the potential for spontaneous bleeding, adjacent tissue compression and convulsive activity. The aim of these report is to describe clinical, pathological and immunohistochemical features of a case of cerebrovascular hamartoma and highlight the diagnosis of these rare brain disorder in dogs.Case: A 10-year-old male dog, a Campeiro Bulldog breed presented convulsions episodes and died before an elective surgical procedure for eyelid nodule removal. Three red nodules were observed in the brain, one between the parietal lobe and the left occipital lobe (in the medium suprasylviam sulcus), the other in the caudal region of the corpus callosum and the third one in the cerebellar cortex. Central nervous system, eyelids and most organs and tissues samples were collected, fixed in 10% formaldehyde and processed for histopathological analysis. Histologically, in the eyelid was detected a sebaceous adenoma. The nervous system samples revealed well-differentiated different sizes vascular structures with thin-walled and blood-filled, promoting compression of the brain. Normal neuropile was detected between the vascular structures substantiating cerebral vascular hamartoma diagnosis in the dog. Immunohistochemical assay was conducted with CD31 (monoclonal mouse antibody anti-CD31, Clone JC70A, Dako Corp.) and Von Willebrand factor (monoclonal mouse antibody anti-Von Willebrand factor, Clone F8/86, Dako Corp.) using the biotin–peroxidase–streptavidin method (PolyDetector Plus DAB–HRP, Bio SB) on CNS sections to confirm the vascular origin of the lining cells in the mass. Discussion: Hamartomas are rarely reported in domestic animals and mostly are of vascular origin. VH in nervous tissues can trigger clinical signs related to hemorrhage, brain space occupation, compression and obstructive secondary hydrocephalus. In general, cerebral VH have a slow progression and usually affected animals are asymptomatic. On the other hand, cerebral vascular hamartomas may also cause clinical signs in very young animals about 15 to 16 months old. In humans, clinical presentation of VH may be related with acquired lesions such as trauma, ionizing radiation, and other central nervous system injuries. In the present case, the dog presented convulsion episode only at 10 years old during pre-chirurgical procedures. The morphological features of the vascular hamartoma we observed in the Campeiro bulldog is classified as capillary teleangiectasia composed by well differentiated capillaries lined with well differentiated endothelial cells interspaced by normal neuronal tissue. Histopathological and immunohistochemical assay are extremely important to differentiate hamartoma from other tumors, since they may be macroscopically similar. The immunolabeling of endotelial cells by anti-CD31 and anti-Von Willebrand factor antibodies in the cerebral VH, highlight the vascular origin of the masses detected. However, it is also important to perform systematic gross examination of the brain in detail to detect even the smallest injuries in asymptomatic animals avoiding underdiagnoses of cerebral VH.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Cerebral Vascular Hamartoma In a Campeiro Bulldog

Barros¹,

Gulgemin²,

Barreto³

et al. 2020

Acta Scientiae. Vet.

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“…Splenic hamartomas, or benign overgrowths of normal splenic tissues, consist of normal red pulp elements in an abnormal quantity that usually present as well‐circumscribed masses 1 3 11 27–29. In this case, the red pulp elements were abnormal or absent and were replaced by vascular spaces and EMH.…”

Section: Discussionmentioning

confidence: 91%

Kasabach‐Merritt‐like syndrome in a dog secondary to isolated splenic haemangiomatosis

Pazzi

Clift

Hartman

et al. 2020

Vet Record Case Reports

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A 13-year-old intact male miniature schnauzer presented with lethargy, distended abdomen and pallor. Pancytopenia was identified on complete blood count with a severe thrombocytopenia. Cavitatory severe splenomegaly was identified on abdominal ultrasound. Two weeks of immunosuppressive therapy had no effect on the thrombocytopenia and a splenectomy was performed. The platelet count returned to normal within 24 hours of splenectomy. Isolated splenic haemangiomatosis was confirmed on histopathology and immunohistochemistry. The anaemia and severe thrombocytopenia in conjunction with the ultrasound findings and histopathology are characteristic of Kasabach-Merritt syndrome in people. This is the first case of Kasabach-Merritt-like syndrome described in the dog.

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“…Hamartomas do not reproduce the normal architecture of the surrounding tissue. 6,7 Hamartomas are most often focal in nature, grossly resemble neoplasia 8 and have been regarded as a link between neoplasm and malformations. 9 Typically, morbidity related to hamartomas is attributable to their infiltration into or mass effect on local surrounding tissues.…”

mentioning

confidence: 99%

“…In the dog, case reports of hamartoma include involvement the spleen, 7 carpus, 10 spinal cord, 9 myocardium, 11 hepatic vasculature, 12 pulmonary vasculature, 13 kidney, 14 hypothalamus, 15 tongue, 16 cranial nerves, 17 respiratory tract, 18,19 and intestines 20 and cerebral vasculature. 21 Few case reports of hamartomas in the cat are available within the veterinary literature.…”

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confidence: 99%

Gastric smooth muscle hamartoma in a cat

Smith

Baltzer

Ruaux

et al. 2010

Journal of Feline Medicine and Surgery

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An 11-year-old cat presented for evaluation of intermittent vomiting, constipation and hyporexia of 3 weeks duration. Ultrasonographic and endoscopic examination revealed a soft tissue mass adjacent to the lower gastro-esophageal sphincter. Surgical excision of the mass was successfully performed resulting in a resolution of clinical signs. Histologically the mass was consistent with a smooth muscle hamartoma. At follow-up 7 months after surgery, the cat remained free from clinical signs.

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Splenic hamartomas in a dog

Cited by 5 publications

References 23 publications

Cerebral Vascular Hamartoma In a Campeiro Bulldog

Cerebral Vascular Hamartoma In a Campeiro Bulldog

Kasabach‐Merritt‐like syndrome in a dog secondary to isolated splenic haemangiomatosis

Gastric smooth muscle hamartoma in a cat

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