Gastric smooth muscle hamartoma in a cat

Smith, Thomas J.; Baltzer, Wendy I.; Ruaux, Craig G.; Heidel, Jerry R.; Carney, Patrick C.

doi:10.1016/j.jfms.2009.10.004

Cited by 13 publications

(17 citation statements)

References 21 publications

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“…A hamartoma is a benign disease that is defined as an excessive and disordered growth of mature cells and tissues that are normally present in the area in which the lesion exists [ 12 ]. Consequently, a vascular hamartoma is a disorganized overgrowth of mature vascular cells; these cells construct abnormal blood vessels and form a tumor-like mass [ 13 ]. In dogs, hamartoma is a rare disease; cases of hamartoma in dogs have been sporadically reported [ 1 , 7 , 16 ].…”

mentioning

confidence: 99%

Mandibular vascular hamartoma in a cat

Takagi

Kagawa²,

Hanazono

et al. 2018

The Journal of Veterinary Medical Science

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confidence: 99%

Mandibular vascular hamartoma in a cat

Takagi

Kagawa²,

Hanazono

et al. 2018

The Journal of Veterinary Medical Science

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“…Gastric smooth muscle hamartoma in an 11-year-old cat was manifested by intermittent vomiting, constipation and reduced appetite for 3 weeks. Surgical treatment was effective (62).…”

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confidence: 99%

“…Brain hamartoma in a 7-year-old dog (59), cerebral vascular hamartoma with petechiae and necrosis in an 11-year-old cat (44) and gastric hamartoma in another 11-year-old cat (62), are just a few examples. This proves that lesions can sometimes grow very slowly and cause clinical symptoms only in geriatric animals.…”

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confidence: 99%

Hamartoma: a rare developmental disorder

Bartyzel¹,

Max²,

Gruszczyńska³

et al. 2017

Medycyna Weterynaryjna

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SummaryHamartoma is a developmental disorder of various body parts and organs. It is characterized by a nonneoplastic growth of tissue with an uneven distribution and proportion of individual cells. Lesions progress for several years, but usually do not give clinical symptoms, and do not undergo malignant transformation. They occur alone or coexist with other defects, sometimes forming a characteristic clinical picture of a syndrome of congenital defects. Mutations in genes, such as PTEN, GLI3, SDH B/D, PIK3CA and ACT1, cause a dysfunction of the tumor suppressor gene and result in an increased neoplastic transformation. Hamartoma is a lesion between developmental disorders and benign tumors, which occurs frequently in humans, but is very rare in domestic animals. In a histopathological examination, however, it is diagnosed relatively often. In the veterinary literature, both hamartoma and choristoma are attributed mostly to errors in embryogenesis and are not considered as preneoplastic lesions.

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“…To the best of our knowledge, only 28 cases of human gastric solitary hamartomatous polyps were so far documented in the literature [15]. In animals, gastric smooth muscle hamartoma has only been described in the abomasum of a calf [5] and adjacent to the lower gastroesophageal sphincter in a cat [4]. Our current case demonstrated extensive branching of the alpha actin stained smooth muscle fibers from muscularis mucosae to the mucosal layer between gastric glands and foveolae and their atrophy.…”

Section: Discussionmentioning

confidence: 56%

“…Gastric polyps (GP) are sessile or pedunculated growths that arise from the mucosa and protrude into the gastric lumen as the result of either hyperplasia or neoplasia [1]. GP occur sporadic in dogs [2,3], cats [4], cattle [5], and horses [6]; they are observed during gastric endoscopy or necropsy. GP are often in the pyloric region, and the affected animals usually do not show any clinical signs however.…”

Section: Introductionmentioning

confidence: 99%

Gastric Smooth Muscle Hamartomas Mimicking Polyps in a Dog: A Case Description and a Review of the Literature

Taulescu

Amorim

Gärtner

et al. 2013

Case Reports in Veterinary Medicine

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This report presents a case of two smooth muscle hamartomas of the stomach in a 10-year-old male Boxer. The clinical history of the animal was of chronic vomiting, weight loss, and intermittent gastric distension, and it died because of chronic and congestive heart failure. Gross, histology, and immunohistochemistry (IHC) exams were performed. On necropsy, in the pyloric region of the stomach, two closely related polypoid growths between 10 and 15 mm in diameter were identified. On the cut sections, both polyps presented white to gray color, with homogenous architecture and well-defined limits. The thickness of the submucosal layer was seen to be increased to 1 cm. No other gastric alterations were identified by the necropsy exam. Histologically, both masses growth consisted of hyperplastic glands lined by foveolar epithelium, arranged in a papillary or branching pattern, and supported by a core of well-vascularised and marked smooth muscle tissue interspersed between glands. No dysplastic cells and mitotic figures were observed in these lesions. Immunohistochemistry revealed a strong cytoplasm labelling for smooth muscle actin of the bundles around the mucosal glands. To our knowledge, this is the first report of smooth muscle hamartomas mimicking multiple gastric polyps in dogs.

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Gastric smooth muscle hamartoma in a cat

Cited by 13 publications

References 21 publications

Mandibular vascular hamartoma in a cat

Mandibular vascular hamartoma in a cat

Hamartoma: a rare developmental disorder

Gastric Smooth Muscle Hamartomas Mimicking Polyps in a Dog: A Case Description and a Review of the Literature

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