Splenic autotransplantation: Determination of the optimum amount required for maximum survival

Steely, William M.; Satava, Richard M.; Brigham, Robert A.; Setser, Edward R.; Davies, Ross S.

doi:10.1016/0022-4804(88)90083-2

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…Iinuma et al 35 found that the most effective site for autotransplantation in rats was the omental pouch, and that 50% of the whole spleen mass was necessary for protection against sepsis. Steely et al 74 reported that autotransplantation of 80% of the spleen in rats is the optimum amount to maximize survival in a model of pneumococcal sepsis. Indeed, Moxon and Schwartz 75 found that rats with heterotopic splenic autotransplantation were not protected against blood stream dissemination but were protected against bacterial meningitis.…”

Section: 67-71mentioning

confidence: 99%

Splenosis and sepsis: The born-again spleen provides poor protection

Connell

Brunner

Kerr³

et al. 2011

Virulence

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Section: 67-71mentioning

confidence: 99%

Splenosis and sepsis: The born-again spleen provides poor protection

Connell

Brunner

Kerr³

et al. 2011

Virulence

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Immunoarchitecture of Regenerated Splenic and Lymph Node Transplants

Pabst

Westermann

Rothkötter

1991

International Review of Cytology

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Autologous Splenic Transplantation for Splenic Trauma

Pisters

Pachter²

1994

Annals of Surgery

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ObjectiveThe authors reviewed the experimental evidence, surgical technique, complications, and results of clinical trials evaluating the role of autologous splenic transplantation for splenic trauma. Summary Background DataSplenorrhaphy and nonoperative management of splenic injuries have now become routine aspects in the management of splenic trauma. Unfortunately, not all splenic injuries are readily amenable to conventional spleen-conserving approaches. Heterotopic splenic autotransplantation has been advocated for patients with severe grade IV and V injuries that would otherwise mandate splenectomy. For this subset of patients, splenic salvage by autotransplantation would theoretically preserve the critical role the spleen plays in the host's defense against infection. MethodsThe relevant literature relating to experimental or clinical aspects of splenic autotransplantation was identified and reviewed. Data are presented on the experimental evaluation of autogenous splenic transplantation, methods and complications of autotransplantation, choice of anatomic site and autograft size, and results of clinical trials in humans. ResultsThe most commonly used technique of autotransplantation in humans involves implanting tissue homogenates or sections of splenic parenchyma into pouches created in the gastrocolic omentum. Most authors have observed evidence of splenic function with normalization of postsplenectomy thrombocytosis, immunoglobulin M levels, and peripheral blood smears. Some degree of immune function of transplanted grafts has been demonstrated with in vivo assays, but the full extent of immunoprotection provided by human splenic autotransplants is currently unknown. ConclusionsMultiple human and animal studies have established that splenic autotransplantation is a relatively safe and easily performed procedure that results in the return of some hematologic and immunologic parameters to baseline levels. Some aspects of reticuloendothelial function are also preserved. Whether this translates into a real reduction in the morbidity or mortality rates from overwhelming bacterial infection is unknown and requires further investigation. 225

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Splenic autotransplantation: Determination of the optimum amount required for maximum survival

Cited by 5 publications

References 11 publications

Splenosis and sepsis: The born-again spleen provides poor protection

Splenosis and sepsis: The born-again spleen provides poor protection

Immunoarchitecture of Regenerated Splenic and Lymph Node Transplants

Autologous Splenic Transplantation for Splenic Trauma

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