Splanchnic lactic acid metabolism in hyperventilation, metabolic alkalosis and shock

Berry, Michael N.; Scheuer, James

doi:10.1016/0026-0495(67)90084-4

Cited by 78 publications

(25 citation statements)

References 23 publications

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“…14,15 The pathophysiology of elevated lactate concentration in dogs because of hepatic ischemia leading to impaired lactate removal has been demonstrated in previous studies. 16,17 Therefore, postoperative lactate concentration in dogs undergoing cholecystectomy for GMs may be used as an auxiliary monitoring and prognostic indicator.…”

Section: Discussionmentioning

confidence: 99%

Clinical Findings and Prognostic Factors for Dogs Undergoing Cholecystectomy for Gall Bladder Mucocele

et al. 2013

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Objective: To report clinical findings and explore prognostic factors for dogs that had cholecystectomy for gall bladder mucocele. Study Design: Retrospective case series. Animals: Dogs (n = 43) with gall bladder mucoceles. Results: Diagnosis of gall bladder mucoceles was confirmed by histopathology and 74% were diagnosed based on preoperative abdominal ultrasonography. Intraoperative evidence of gall bladder rupture was noted in 10 dogs (23%), and 16 (37%) had evidence of previous leakage in the abdominal cavity. One dog had positive bacterial growth from the gall bladder content. The most common histopathologic findings in liver biopsies obtained at surgery were cholangiohepatitis, biliary hyperplasia, or cholestasis. Univariate analysis showed evidence of postoperative hypotension (P = .05) to be significantly negatively associated with survival. Significant difference in mean postoperative serum lactate (P = .034) and postoperative packed cell volume (P = .063) between dogs that survived and died was also noted. Conclusions: Elevations in postoperative serum lactate concentrations and immediate postoperative hypotension in dogs undergoing cholecystectomy for gall bladder mucoceles are associated with poor clinical outcome.Although a recognized disease process for several decades, the incidence of gall bladder mucoceles (GM) in dogs appears to be increasing.

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Section: Discussionmentioning

confidence: 99%

Clinical Findings and Prognostic Factors for Dogs Undergoing Cholecystectomy for Gall Bladder Mucocele

et al. 2013

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“…the respiratory muscles and skeletal muscle (29,30) increased their production of lactate. Concomitantly, hepatic lactate clearance (31,32) and whole body net elimination of lactate (27,33,34) were probably diminished.…”

Section: Discussionmentioning

confidence: 99%

Response to Low Cardiac Output: Developmental Differences in Metabolism during Oxygen Deficit and Recovery in Lambs

Fahey

Lister

1989

Pediatr Res

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ABSTRACT. When cardiac output is critically lowered, whole body O2 consumption decreases and an O2 deficit accumulates. With restoration of cardiac output, an excess 0 2 consumption is expected in order to "repay" some or all of the O2 deficit. We tested the hypothesis that young lambs, with higher resting O2 consumption, cardiac output and growth rates than older lambs, would repay less of their 0 2 deficit because they have a higher proportion of nonessential metabolism. We reduced cardiac output acutely by inflating a Foley catheter in the right atrium of spontaneously breathing, sedated lambs at ages 2 (n = 5) and 8 ( n = 5) wk. Each lamb was studied with low cardiac output periods of 30 and 60 min on different days. Aortic and pulmonary artery blood pressures, gases, and O2 saturations, venous Hb, and arterial lactate concentrations were measured every 10 min during baseline, low output, and 60 min of recovery. Oxygen consumption was monitored continuously. Oxygen deficit and excess O2 of recovery were calculated from the time integral of the difference between O2 consumption at baseline and during the respective study period. The average percent decreases in cardiac output (66.4 and 64.6%) and 0 2 consumption (38.1 and 35.1%) were similar in the 2-and 8-wk groups, respectively. There was no consistent relation between 0 2 deficit and O2 repayment in either age group. However, on average the 2-wk group repaid a significantly lower percentage (3 f 16%, mean f SEM) than 8-wk-olds (76 k 29%). Moreover, lactate increased linearly with time and O2 deficit in both age groups, but lactate accumulated at a significantly lower rate in the 2-wk as compared to the 8-wk group for comparable deficits. We speculate that, during periods of very low cardiac output, 2-wk-old lambs not only decrease O2 consumption, but also decrease metabolic demands, possibly by suppressing nonessential metabolism. This results in fewer energy stores that need to be replenished during recovery. This is a potential mechanism for the greater tolerance of young animals to hypoxic stresses. (Pediatr Res 26: 180-187, 1989) When 0 2 supply to the tissues is critically reduced by hypoxemia, anemia, or low cardiac output, whole body O2 consumption decreases and an O2 deficit accumulates throughout the hypoxic period (1-3). With restoration of 0 2 supply, there is a Received November 3, 1988; accepted May 11, 1989. Correspondence John T. Fahey, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510.Supported by a grant from the American Heart Association and the Connecticut Heart Affiliate. G. L. is an Established Investigator of the American Heart Association. transient excess in O2 consumption above the initial baseline level and it has been suggested that this excess represents "repayment" of some or all of the O2 deficit (4,5) in a manner analogous to exercise (6). However, in studies of hypoxic hypoxia by Adams and Cain (5) in adult dogs, it was observed that there was neither "repayment" of all n...

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“…respiratory, alkalosis, respiratory acidosis and metabolic acidosis as in diabetes. 4 In recent years McLean's group demonstrated the usefulness of blood lactate as an indicator of the severity of clinical shock and its prognosis.7 13,14 A similar report was made by Broder and Weil. 6 The number of patients used in these studies ranged from 25 to 63.…”

mentioning

confidence: 74%

Blood Lactate in the Prognosis of Various Forms of Shock

1971

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Splanchnic lactic acid metabolism in hyperventilation, metabolic alkalosis and shock

Cited by 78 publications

References 23 publications

Clinical Findings and Prognostic Factors for Dogs Undergoing Cholecystectomy for Gall Bladder Mucocele

Clinical Findings and Prognostic Factors for Dogs Undergoing Cholecystectomy for Gall Bladder Mucocele

Response to Low Cardiac Output: Developmental Differences in Metabolism during Oxygen Deficit and Recovery in Lambs

Blood Lactate in the Prognosis of Various Forms of Shock

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