Spirometric “Lung Age” estimation for North African population

The impacts of parity on lung function data (LFD) of healthy females aged 40 years and more issued from an upper middle income country (Algeria): A comparative study

“…Fourthly, a North-African study showed that high parity leads to a decrease in total airway conductance [6]. On the other hand, the present study findings related to FEV 1 FVC and peripheral airway flows (Table 2) are partially opposite with these of others concluding that multiparity negatively impacts LFD [6, 7, 12, 13, 15] (S2 File). First, a study including females aged ≥ 60 years [7], concluded that compared to females with a parity ≤ 4, those with a parity > 4 had lower FEV 1 , FEV 1 /FVC, MMEF and PEF.…”

“…The discrepancy between reported results in literature may be due to some different obstetric/anthropometric characteristics of the included females (S2 File): different parity means [4±2 [6], 5±3 [12, 13], 6±3 (this study)], different age ranges [21–28 [16], 18–92 [11], 19–90 [12, 13], 40–74 (this study), 45–90 [6], 60–96 [7]], different applied cutoff for parities [1 [11, 15], 3 [6], 4 [7], 6 (this study)], different groups of parities [n = 2 [6, 7, 11, 15], n = 3 [6], n = 4 [15], n = 5 [14, 16]].…”

“…Thirdly, compared to Brazilian nulliparous females aged < 25 years, those with a parity ≥ 1 had lower MMEF during the first trimester and lower PEF during the third trimester [15]. Fourthly, it appears that parity accelerated lung-aging, with an increase of one parity rising the estimated lung-age by 1.2 years [12, 13]. Finally, findings related to TGV, RV and TLC (Tables 2 and 3) are totally opposite with these of the only study that evaluated static volumes [6] (S2 File).…”

“…To the best of the authors’ knowledge, few studies, published between 1999 and 2018, have raised the impact of parity on healthy females’ LFD [USA (n = 1 [ 11]), Tunisia (n = 3 [6, 7, 12]), Nigeria (n = 2 [14, 16]), Brazil (n = 1) [15]] with contradictory results. On the one hand, some studies concluded that high parity was associated with positive effects on LFD of American [ eg , larger forced expiratory volume in 1 s (FEV 1 ) and FVC [11]] or of Nigerian [ eg , increases in FEV 1 and FVC [14], even across all females positions [16]] In the other hand, some other studies concluded that high parity was associated with negative effects on LFD of Tunisian [ eg , reduction in peak flow rate [7], a tendency towards a proximal obstructive ventilatory defect (OVD) [6] and acceleration of lung-aging [12, 13]], or of Brazilian aged < 25 years [ eg , lower maximal mid-expiratory flow (MMEF) and peak expiratory flow (PEF) [15]]. Moreover, a North-African study concluded that compared to aging by one year, the parity increase of one unit, caused a greater LFD’ decline [ eg , FEV 1 declines were 23 and 33 mL, respectively, per year of age and when parity increases by one unit [6]].…”

Fraction of Exhaled Nitric Oxide (FeNO) Norms in Healthy Tunisian Adults

“…Thus, a table of normal values according to age ranges was established. In addition, the need of reference equations specific to Tunisian/Arab adults' populations has been demonstrated for several lung function parameters [ 26 – 33 ], but not for Fe NO . Furthermore, and to the best of our knowledge, Fe NO norms are established only in one Arabic population (Saudi Arabian males' [ 16 ]) and the applicability and reliability of these norms [ 16 ] should be assessed as regards to Tunisian Arab adults, in order to avoid erroneous clinical interpretation of Fe NO data in this population.…”