Spirocyclic derivatives as antioxidants: a review

Abstract

This article provides an overview of the synthesis and various antioxidant activities found in naturally occurring and synthetic spiro compounds.

Spiro Derivatives in the Discovery of New Pesticides: A Research Review

“…Spiro compounds are organic compounds in which a single atom connects at least two rings. − They possess a combination of characteristics that other organic compounds do not, such as a rigid, stable structure, spiro conjugation, and spiro superconjugation. , Unlike flat aromatic heterocyclic compounds, the inherent high saturation (Fsp3) and significant three-dimensional characteristics of spiro rings make them widely used in the fields of synthetic chemistry, materials chemistry, and supramolecular chemistry. − The water solubility and lipophilicity properties of lead molecules can be optimized to improve their development into useful drugs that are less prone to producing resistance . Spiro motifs are ubiquitous in natural products and drugs (Figure ).…”

Synthesis of bis-spirocyclic derivatives of 3-azabicyclo[3.1.0]hexane via cyclopropene cycloadditions to the stable azomethine ylide derived from Ruhemann's purple

“…In this regard, there is interest in studying heterocyclic spiro compounds for drug discovery. These compounds were found to exhibit a broad range of biological activities, including antioxidant [ 3 ], anticancer [ 4 ], antidiabetic [ 5 ], and antibacterial [ 6 ] properties. It is also worth noting that spiro compounds have found application in agriculture as fungicides [ 7 ], as well as in materials science as organic semiconductors [ 8 ].…”

A review on advances in synthetic methodology and biological profile of spirothiazolidin‐4‐ones

“…The spiroheterocycles containing nitrogen, oxygen, sulfur atoms display diverse pharmacological activities such as anti‐depressants [20], anti‐arrhythmic agents [21, 22], ACC inhibitors etc. [23] (Figure 3).…”