Spirochetes in the Aqueous Humor in Seronegative Ocular Syphilis

Long-term results of penicillin treatment of early and late forms of syphilis in the rabbit.

“…The experimental research of Collart and his colleagues has been confirmed in varying degrees by Yobs, Rockwell, and Clark (1964), Goldman and Girard (1967), Smith andIsrael (1967, 1968), and other writers. Willcox (1964) cast doubt on the significance of Collart's results, pointing out that the structures seen were perhaps not Treponema pallidum, and he set aside the positive results they obtained by infecting rabbits with lymph nodes of treated infected subjects.…”

“…Willcox (1964) cast doubt on the significance of Collart's results, pointing out that the structures seen were perhaps not Treponema pallidum, and he set aside the positive results they obtained by infecting rabbits with lymph nodes of treated infected subjects. Guthe and Ids0e (1967) said that Collart's research should be considered in the light of the latest data on treponematoses, mentioning the work of Fribourg-Blanc (1966), who observed, in the lymph nodes of African monkeys with positive TPI and fluorescent antibody test results, dormant treponemes which became pathogenic after passage to hamsters, and also the research of Smith andIsrael (1967, 1968), who found treponemes in the aqueous humour of the eye of subjects with late forms of syphilis.…”

Neurosyphilis With Unilateral Optic Tract Lesion Causing Homonymous Hemianopia

“…2,3 Tabes optica may also cause slowly progressive hemianopia. 12 However, this reported patient developed slowly progressive binasal anopia and optic tract atrophy demonstrated by MRI.…”

“…1 The main causes of such lesions are infarction or tumor, and only few patients with neurosyphilis presenting homonymous hemianopia are reported although the precise anatomic diagnoses were unclear. 2,3 We report a patient with neurosyphilis presenting with a homonymous hemianopia caused by a unilateral optic tract lesion demonstrated by MRI. After administration of benzylpenicillin, the clinical symptoms and MRI abnormality is resolved.…”

Neuroretinitis in secondary syphilis

“…After intravenous penicillin treatment the CSF became normal. Smith and Israel (1967) reported the presence of spirochaetes in the anterior chamber after intramuscular penicillin treatment. Mohr et al (1977) found inadequate levels of penicillin in the CSF when the administration was intramuscular.…”