Long-term results of penicillin treatment of early and late forms of syphilis in the rabbit.

Ovcinnikov, N M; Korbut, S. E.; Bednova, V. N.; Timcenko, G F; Milonova, T I

doi:10.1136/sti.49.5.413

Sexually Transmitted Infections

1973

DOI: 10.1136/sti.49.5.413

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Long-term results of penicillin treatment of early and late forms of syphilis in the rabbit.

N M Ovcinnikov¹,

S. E. Korbut²,

V. N. Bednova³

et al.

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1984

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Cited by 5 publications

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“…syphiloma model is widely accepted as an appropriate model for evaluation of antimicrobial regimens in Treponema pallidum infections (8,10). In addition, we felt that inclusion of an intravenous model might provide information relevant to the disseminated (secondary) stage of human syphilis, even though the former model must be regarded as a primary infection.…”

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Evaluation of Sch 29482 in experimental syphilis and comparison with penicillin G benzathine in disseminated disease and localized infection

Baughn¹,

Adams²,

Musher³

1984

Antimicrob Agents Chemother

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The present study was designed to assess the in vivo activity of Sch 29482, a new penem antibiotic, against disseminated and localized Treponema pallidum infections in rabbits. Animals were inoculated either intravenously or intradermally. Randomized groups then received 25 or 50 mg of Sch 29482 per kilogram of body weight twice a day for 7 days, two weekly injections of 200,000 U of penicillin G benzathine for comparative purposes, or no antibiotic therapy. In both infection models, striking differences were noted between the untreated control rabbits and rabbits receiving penicillin G benzathine or high-dose Sch 29482.Intravenously infected rabbits did not develop disseminated lesions or orchitis, and chancres produced by intradermal infection regressed and healed rapidly after both treatment regimens. Infectivity studies also suggested that high-dose Sch 29482 and penicillin G benzathine were effective since the testes and lymph nodes of treated animals were free of infectious organisms. Treatment of animals with the lower dose of Sch 29482 represented borderline or suboptimal therapy, with a failure rate of one in four for each infection model.

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mentioning

confidence: 99%

Evaluation of Sch 29482 in experimental syphilis and comparison with penicillin G benzathine in disseminated disease and localized infection

Baughn¹,

Adams²,

Musher³

1984

Antimicrob Agents Chemother

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Clinical course and treatment of venereal spirochaetosis in New Zealand white rabbits.

Rf¹,

Lukehart²,

Talburt³

et al. 1984

Sexually Transmitted Infections

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SUMMARY Ten sporadic cases of venereal spirochaetosis, caused by Treponema paraluiscuniculi, were seen in New Zealand white rabbits in two years. An equal number of males and females were affected. Females tended to have milder clinical signs than males. Lesions were usually found on the prepuce in males and the vulva in females, although the anus and skin of the perineum were also affected. Facial lesions were rare. Lesions healed in seven to 28 days in rabbits treated with penicillin. Eight rabbits had antibodies reactive in the Venereal Disease Research Laboratory (VDRL), rapid plasma reagin (RPR), and fluorescent treponemal antibody absorbed (FTA-ABS) tests when the disease was first diagnosed. In several rabbits followed longitudinally, RPR test results became negative two to four months after antimicrobial treatment, VDRL antibody titres diminished but usually persisted at low levels, while FTA-ABS antibodies declined slowly and were still evident 12 months after treatment.

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Survival of treponemes after treatment: comments, clinical conclusions, and recommendations.

Dunlop¹

1985

Sexually Transmitted Infections

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Long-term results of penicillin treatment of early and late forms of syphilis in the rabbit.

Cited by 5 publications

References 4 publications

Evaluation of Sch 29482 in experimental syphilis and comparison with penicillin G benzathine in disseminated disease and localized infection

Evaluation of Sch 29482 in experimental syphilis and comparison with penicillin G benzathine in disseminated disease and localized infection

Clinical course and treatment of venereal spirochaetosis in New Zealand white rabbits.

Survival of treponemes after treatment: comments, clinical conclusions, and recommendations.

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