Spine trabecular bone scores and bone mineral density of postmenopausal Taiwanese women

Huang, Meilan; Hsieh, Tsyh-Jyi; Lin, Song-Shei; Huang, Wen-Chuan

doi:10.1097/gme.0000000000002058

Cited by 4 publications

(6 citation statements)

References 49 publications

(113 reference statements)

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“…Compared with women, TBS (L 1-4 ) levels did not plateau in Chinese men between the ages of 20 and 74 years. The declines in TBS and BMD were both greater in women than in men, especially after the age of 50 years, which is related to the decline in estrogen levels after menopause (16).…”

Section: Discussionmentioning

confidence: 89%

Establishing age-adjusted trabecular bone score curves using dual-energy X-ray absorptiometry in Chinese women and men: a cross-sectional study

Wu¹,

Wu²,

Zhang³

et al. 2023

Quant Imaging Med Surg

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Background: Trabecular bone score (TBS) is a relatively new gray-level textural parameter that provides information on bone microarchitecture. TBS has been shown to be a good predictor of fragility fractures independent of bone density and clinical risk factors. Estimating the normal reference values of TBS in both sexes among the Chinese population is necessary to improve the clinical fracture risk assessment.Methods: This retrospective study enrolled healthy Chinese participants living in Guangzhou, China, including 1,018 men and 3,061 women (aged 20-74 years). Bone mineral density images were obtained with dual-energy X-ray absorptiometry (DXA) scanning of the lumbar region (L 1-4 ). Lumbar spine TBS values were calculated. The correlations between the scores and bone mineral density, age, height, and weight were calculated for men and women. A TBS reference plot was established in relation to age (20-74 years). Values 2 standard deviations below the mean score for each sex were used as the cutoff values for low-quality bone. Results:The TBS (L 1-4 ) was significantly higher in Chinese men than in Chinese women. The scores peaked at 25-29 years (1.47±0.08 years) in men and at 20-24 years (1.43±0.08 years) in women. According to the statistical confidence interval, in Chinese males, a TBS ≥1.39 is considered normal, a TBS between 1.31 and 1.39 indicates partially degraded microarchitecture, and a TBS ≤1.31 indicates degraded microarchitecture. In Chinese females, a TBS ≥1.35 is considered normal, a TBS between 1.27 and 1.35 indicates partially degraded microarchitecture, and a TBS ≤1.27 indicates degraded microarchitecture.Conclusions: This study provides normative reference ranges for the TBS in Chinese men and women.Chinese men with a TBS score ≤1.31 and Chinese women with a TBS score ≤1.27 are can be considered to have reduced bone microarchitecture and may be at higher risk of having osteoporosis fractures.

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Section: Discussionmentioning

confidence: 89%

Establishing age-adjusted trabecular bone score curves using dual-energy X-ray absorptiometry in Chinese women and men: a cross-sectional study

Wu¹,

Wu²,

Zhang³

et al. 2023

Quant Imaging Med Surg

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“…Menopause is known to be associated with bone loss and the development of osteoporosis in women. Previous studies have demonstrated that BMD decreases with age in women older than 50 years, 8 as well as in those with late perimenopause and postmenopause. 13 Consistent with these findings, our study revealed significant associations between both lumbar and femoral neck BMDs and factors such as age, BMI, menopausal duration, and lumbar muscle sizes.…”

Section: Discussionmentioning

confidence: 96%

“…Dual-energy x-ray absorptiometry (DXA) is considered the criterion standard for measuring BMD, and the lowest T-score of BMD at the lumbar spine, femoral neck, or total hip is recommended for diagnosing osteoporosis 5 . Recent meta-analyses have consistently shown a higher prevalence of osteoporosis in postmenopausal women compared with men 6-8 …”

mentioning

confidence: 99%

“…5 Recent meta-analyses have consistently shown a higher prevalence of osteoporosis in postmenopausal women compared with men. [6][7][8] Estrogen deficiency in menopausal women further contributes to the development of osteoporosis by disrupting the balance between osteoclastogenesis and osteoblastogenesis. During menopause, there is an increase in osteoclastic resorption activity, while osteoblastic activity decreases, resulting in a net loss of bone tissue.…”

mentioning

confidence: 99%

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Association between lumbar muscle size and bone mineral density in nonfractured postmenopausal women with and without osteoporosis

Hou,

Hsieh,

Chou

2024

Menopause

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Objective Estrogen deficiency in postmenopausal women is associated with bone loss and a decline in muscle mass. However, the associations between lumbar muscle size and bone mineral density (BMD) in postmenopausal women with and without osteoporosis remain unclear. The aim of this study was to investigate the associations between lumbar muscle size and BMD in nonfractured postmenopausal women with osteoporosis and those with osteopenia. Methods A total of 89 postmenopausal women with osteopenia (n = 53) and osteoporosis (n = 36) were retrospectively enrolled in this study from 2014 to 2022. All participants underwent lumbar magnetic resonance imaging and dual-energy absorptiometry within a month. The lean lumbar muscle sizes at different lumbar levels were quantitatively evaluated on axial T1-weighted images. The associations between lumbar muscle size and BMD were analyzed using Pearson's correlation analysis. Results The osteoporosis group had significantly smaller lean psoas muscle sizes than the osteopenia group. Based on the correlation analysis, the erector spinae and multifidus muscle sizes were significantly associated with lumbar and femoral neck BMDs in the osteoporosis group. However, no significant association was found between lean psoas muscle size and BMDs in the osteopenia group. Thus, the associations between lumbar muscle decline and bone loss differed between postmenopausal women with osteoporosis and those with osteopenia. Conclusions The study findings suggest differences in the associations between BMD and lumbar muscle size between postmenopausal women with osteoporosis and those with osteopenia.

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“…Because BMD can only be used to assess bone mass but not bone quality, BMD often underestimates the risk of fracture in the population. TBS can be used as an adjunct measure of BMD and as an assessment tool for the risk of osteoporotic fractures [9].…”

Section: Introductionmentioning

confidence: 99%

Association between trabecular bone score and type 1 diabetes: A meta-analysis of cross-sectional study

Pan,

Zhang,

Zhao

2023

Preprint

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Background: Bone fragility is a recognized complication of Type 1 diabetes(T1D). Thus, lower trabecular bone score(TBS) measurements in T1D patients can be predicted. However, the results of current studies on TBS in patients with T1D are inconsistent. In this context, the present study aimed to test the hypothesis that T1D is associated with lower TBS through a meta-analysis. Methods: An electronic search of the literature was conducted using PubMed, Embase and Web of science databases to identify studies related to TBS and T1D, supplemented by an additional manual check of the reference list of relevant original and review articles. All data was analyzed using a random effects model. Results were compared using standardized mean differences (SMD) and 95% confidence intervals (CI). P≤0.05 was considered statistically significant. Review Manager 5.4 software and Stata 17.0 software were used for statistical analysis. Results: Seven cross-sectional studies involving 848 participants were included. TBS was lower in T1D patients than in healthy controls on random effects analysis, with no heterogeneity(SMD =-0.39, 95%CI [-0.53, -0.24], P < 0.001; I2=0%). In addition, by subgroup analysis, T1D patients were strongly associated with reduced TBS in different regions and age groups, and the results were independent of covariate adjustment. Conclusion: This study showed that TBS was lower in patients with T1D than in healthy individuals with normal blood glucose levels, suggesting that TBS may be a useful measure to assess fracture risk in T1D.

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Spine trabecular bone scores and bone mineral density of postmenopausal Taiwanese women

Cited by 4 publications

References 49 publications

Establishing age-adjusted trabecular bone score curves using dual-energy X-ray absorptiometry in Chinese women and men: a cross-sectional study

Establishing age-adjusted trabecular bone score curves using dual-energy X-ray absorptiometry in Chinese women and men: a cross-sectional study

Association between lumbar muscle size and bone mineral density in nonfractured postmenopausal women with and without osteoporosis

Association between trabecular bone score and type 1 diabetes: A meta-analysis of cross-sectional study

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