Study design: A retrospective hospital-based study. Objectives: To describe the epidemiologic features of traumatic spinal cord injury (TSCI) in Anhui Province. Setting: Two hospitals within Anhui Province, China. Methods: We retrospectively reviewed the hospital records on all patients with TSCI, admitted between 1 January 2007 and 31 December 2010 (n ¼ 761). Variables included age, gender, occupation, neurological level, severity of injury, cause and treatment. Results: Seven hundred and sixty-one cases of TSCI were identified. Five hundred and eighty eight were males (77.3%) and 173 were females (22.7%), with a mean age of 45 years (s.d. ¼ 13, range from 5 to 87). Fall from height was the leading cause of injury (52.6%), followed by transport (21.2%). The neurological lesion levels were cervical (46.3%), lumbosacral (33.3%) and thoracic (20.4%). Conclusion: Prevention strategies for TSCI should target 30-60 age group, males, farmers and fall from height. The results of this study will serve as a basis for further studies on TSCI. The prevention strategies and treatment should be designed according to the injury features. Epidemiologic studies identify high-risk groups and provide useful information for prevention efforts. It is, therefore, imperative to conduct epidemiologic studies of TSCI in order to formulate corresponding intervention strategies to epidemiological features. In this study, we outlined the epidemiological features of TSCI, which included age, gender, cause, occupation, neurological level and severity of injury at admission, treatment and so on. The results of this study will serve as a base for design prevention strategies and epidemiological studies in order to reduce the number of patients with TSCI.