Spindle cell carcinoma of the mandible: Clinicopathological and immunohistochemical characteristics

Al-Bayaty, H.F.; Balkaran, Ramaa

doi:10.1016/j.jobcr.2015.08.009

Cited by 6 publications

(8 citation statements)

References 7 publications

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“…We also conducted a literature review considering recurrence in cases of SpSCC in the head and neck region and other information such as demographic data, primary tumor, location, treatment, and time of recurrence. 7,9,10,[27][28][29][30][31][32][33][34] In most cases, the location of recurrence and the initial site of involvement were the same. The initial treatment most commonly used was a combination of surgery and radiotherapy, and surgery alone was often associated with recurrence.…”

Section: Discussionmentioning

confidence: 96%

“…7 The clinical presentation of SpSCC usually vary from exophytic, polypoid mass with an ulcerated surface to an infiltrative ulcer and the histopathological characteristics exhibit a dysplastic epithelium with foci of infiltration and connective tissue stroma containing numerous spindle-shaped cells, many of them round to oval in shape with eosinophilic and vacuolated cytoplasm, nuclear hyperchromatism and atypical mitoses. 8,9 Interestingly, SpSCC after radiotherapy treatment in some conventional SCC patients have been reported. 10 Thus, a detailed clinicopathological analysis of similar cases is encouraged better to understand their pathogenesis, treatment, and prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: an immunohistochemical study

et al. 2021

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: an immunohistochemical study

et al. 2021

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“…These tumours present with a wide range of clinical features, including painless or painful smooth rubbery firm masses with or without ulceration, tooth mobility, epistaxis, nasal obstruction, otalgia and a variety of other symptoms depending on the site of the lesion. [2][3][4][5]8,10 Clinically, oral LMS is often confused with other benign and malignant lesions. With regards to the current patient, the clinical and macroscopic features of the case ostensibly mimicked a benign lesion.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Besides early diagnosis, the prognosis of oral LMS patients depends on the tumour grade, size, site and treatment. [20][21][22] Currently, there are no standard criteria for therapy, although the complete excision of the tumour with wide surgical margins is recommended.…”

Section: Discussionmentioning

confidence: 99%

Gingival Leiomyosarcoma in a Young Woman: Case report and literature review

Viviano

Miracco

Lorenzini

et al. 2018

Sultan Qaboos Univ Med J

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Leiomyosarcoma (LMS) is a rare mesenchymal malignancy, of which 3-10% of cases occur in the head and neck region. We report a 22-year-old woman who was referred to the University Hospital of Siena, Italy, in 2016 with an ostensibly benign asymptomatic lump on the mandibular gingiva. The lesion grew rapidly, causing otalgia in the right ear. An excisional biopsy was performed and primary LMS was diagnosed histologically. Subsequently, the patient underwent radical re-excision of the perilesional mucosa, a partial bone resection and the extraction of four teeth. No recurrences or metastases were detectable at a 20-month follow-up. This report discusses the differential diagnosis of LMS with regards to other benign and malignant lesions and reviews the recent literature on primary and secondary oral LMS. Due to its innocuous clinical features-including its asymptomatic nature and presentation at a young age-this aggressive malignancy can go undetected; therefore, an early histopathological diagnosis is crucial.

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“…

Intraoral spindle cell carcinoma (SpCC), also known as pseudosarcoma, sarcomatoid carcinoma, and carcinosarcoma, is a rare aggressive subtype of squamous cell carcinoma (SCC), accounting for less than 2% of all intraoral tumors (Al-Bayaty & Balkaran, 2016;

…”

mentioning

confidence: 99%

Comprehensive analyses of intraoral spindle cell carcinoma: A rare disease entity revisited

Sang

Dai

et al. 2021

Oral Diseases

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Objective The present study was aimed to comprehensively characterize the epidemiological, clinicopathological characteristics, treatments, and prognosis of intraoral spindle cell carcinoma (SpCC). Materials and Methods Patients diagnosed with intraoral SpCC at our institution in the past 15 years (2005–2019) were screened from inpatient disease registry. All relevant data concerning patients with intraoral SpCC were retrieved. Previous reports about intraoral SpCC with adequate clinicopathological data in both English literature and Chinese literature were collected. Eligible cases were further reviewed and pooled for statistical analyses. Results Six patients (5 females and 1 male; average age: 59 years) with intraoral SpCC were histopathologically diagnosed and surgically treated at our institution. The literature review identified another 63 published cases from 34 articles. Most cases were presented in the fifth to seventh decade of life with a male preponderance. Gingiva (23/69, 33.3%) was the most common site followed by the tongue (19/69, 27.5%) and buccal mucosa (8/69, 11.6%). Complete surgical ablation remains the primary treatment option. Tumor size, pathological grades, cervical node metastasis, and distant metastasis were significantly associated with reduced survival. Conclusions Intraoral SpCC is an uncommon and aggressive malignancy with dismal prognosis. Much attention and effort are needed to characterize this rare entity and improve its clinical outcomes.

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Spindle cell carcinoma of the mandible: Clinicopathological and immunohistochemical characteristics

Cited by 6 publications

References 7 publications

Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: an immunohistochemical study

Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: an immunohistochemical study

Gingival Leiomyosarcoma in a Young Woman: Case report and literature review

Comprehensive analyses of intraoral spindle cell carcinoma: A rare disease entity revisited

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