Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: an immunohistochemical study

Ferrisse, Túlio Morandin; Rocha, Audrey Foster Lefort; Lança, Maria Letícia De Almeida; Silveira, Heitor Albergoni; Almeida, Luciana Yamamoto; Bufalino, Andréia; León, Jorge Esquiche

doi:10.4322/acr.2020.219

Cited by 1 publication

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“…Spindle cell squamous cell carcinoma (SpSCC) is a rare phenomenon in head and neck region. Ferrisse et al (2021) have reported that post-radiotherapy occurrence of recurrent SpSCC at the same site of lingual origin after an immunohistochemical analysis. In our study, KSCs are also frequently observed in HBMN cases.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Cytopathology of Human Buccal Mucosa Neoplasm

2023

European Journal of Medicine

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The objective of the present study is to investigate the frequency of pleomorphic cytological atypias in the exfoliated cytosmears of human buccal mucosa neoplasms (HBMN), pattern of cervical lymph node (CLN) metastasis and to establish its role as a diagnostic criterion for early detection of oral cancer.In a hospital-based case-control study, a total of 126 subjects (63 HBMN cases and 63 healthy individuals) were included. Two scalpel-scraped exfoliated cytosmears were collected from the affected site of the buccal mucosa and were fixed in aceto-alcohol (1:3) immediately. Cytosmears were stained with Papanicolaou's stain and Giemsa's stain. Cat Cam 1.30 (1.3 Mega Pixel) microscope camera was used for phptomicrography. Software package Palaeontological Statistics (PAST) ®, Version 2.17 was used for statistical analysis.Cytological pleomorphism was well observed exhibiting a number atypias in the exfoliated cytosmears of HBMN. The frequencies of typically atypical cells like KSC, KTC, KSC-A, KFC, KRC, PKSC, MNC and NMSCs are observed to be directly correlated with the degree of pathogenicity at different stages of oral carcinogenesis. Diagnostically, the Sensitivity was calculated to be 93.1 % and Specificity was 100 %, Positive Predictive Value (PPV) was 100 %, Negative Predictive Value (NPV) was 55.6 % and the accuracy was 93.7 %.Presence of any such cytological atypias in the exfoliated cytosmears of HBMN indicates the state of malignancy and thus, the finding is practically helpful in determining the stage of the HBMN. However, the role of tobacco and alcohol in connection to unusual CLN metastasis with particular reference to the HBMN needs further research.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Cytopathology of Human Buccal Mucosa Neoplasm

2023

European Journal of Medicine

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Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: an immunohistochemical study

Cited by 1 publication

References 40 publications

Diagnostic Cytopathology of Human Buccal Mucosa Neoplasm

Diagnostic Cytopathology of Human Buccal Mucosa Neoplasm

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