Spindle cell carcinoma of the larynx: Review of 26 cases including DNA content and immunohistochemistry

Lewis, Jean E.; Olsen, Kerry D.; Sebo, Thomas J.

doi:10.1016/s0046-8177(97)90175-1

Cited by 164 publications

(168 citation statements)

References 34 publications

Supporting

Mentioning

146

Contrasting

Unclassified

Order By: Relevance

“…Sarcomatoid (spindle cell) carcinomas of the head and neck are unusual variants of squamous carcinoma commonly reported in the larynx but also described in other mucosal sites such as gingiva, tongue, hypopharynx and nasal cavity [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. These tumors have now been proved to be monoclonal, evolving from conventional squamous carcinoma with dedifferentiation associated with sarcomatoid transformation [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

Viswanathan

Rahman

Pallavi

et al. 2010

Head and Neck Pathol

167

177

View full text Add to dashboard Cite

Sarcomatoid carcinomas are biphasic tumors proven to be monoclonal dedifferentiated forms of conventional squamous carcinomas. This study evaluates their clinicopathologic characteristics in head and neck mucosal sites and the problems in distinguishing them from other spindle cell tumors. A total of 103 cases with a confirmed diagnosis of sarcomatoid carcinoma accessioned in the pathology department of a tertiary referral cancer centre over a period of 7 years (2004)(2005)(2006)(2007)(2008)(2009)(2010) were studied. An algorithm used for their diagnosis is presented. Ages of the patients were 22-90 years (median 53 years), and male:female ratio was 3.7:1. Site distribution was oral cavity (n = 65, 63.1%), larynx (18, 17.5%), oropharynx/hypopharynx (12, 10.7%), maxilla (6, 5.8%) and metastatic nodes (2, 1.9%). A large number of patients (95%) presented with a mass lesion of less than 1 year duration. Histopathologically, epithelial differentiation was evident on morphology in 48 (46.6%) cases, only on IHC in 34 (33%) cases, and in 21 (20.4%) no epithelial differentiation was seen. Typically, tumors were polypoidal (92, 89.3%) and ulcerated (95, 92.2%) with cells arranged predominantly in fascicles (59, 57.3%) or storiform pattern (17, 16.5%) amidst collagenous (50, 48.5%) or myxoid matrix (35, 34%). Anaplasia (2?/3?) and mitosis[10 per 10 HPF were noted in 96 (93.2%) cases. IHC was done in 82 cases; 55 (66.7%) showed positivity for epithelial markers with aberrant expression of mesenchymal markers in 43 (41.7%). Diagnosis of sarcomatoid squamous carcinoma is challenging because of overlapping histopathological features with other spindle cell tumors. Understanding their clinicopathologic characteristics facilitates their diagnosis and appropriate clinical management.

show abstract

Section: Introductionmentioning

confidence: 99%

Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

Viswanathan

Rahman

Pallavi

et al. 2010

Head and Neck Pathol

167

177

View full text Add to dashboard Cite

show abstract

“…Predominantemente se ubica en glotis y se presenta como un tumor polipoídeo en la gran mayoría de los casos 5,8,17,19,20 . Como factor de riesgo el antecedente de tabaquismo y alcohol se ha descrito en 87% y 48% de los casos, respectivamente y tiene una clara predominancia por el sexo masculino en una razón de entre 7:1 a 13:1 8,9,17 .…”

Section: Discussionunclassified

Carcinosarcoma de laringe: Reporte de dos casos

et al. 2017

Rev. Otorrinolaringol. Cir. Cabeza Cuello

View full text Add to dashboard Cite

show abstract

“…Oral cavity is the next most frequent site for this tumor affecting the lower lips, tongue and buccal mucosa [15]. Heterologous elements, such as osteocartilagenous elements, in SPCs have been documented in 7-15 % of cases of SPCs depending on the subsite in head and neck [1,3,16]. However, rhabdomyosarcomatous differentiation in SPC is exceptionally rare.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical course of laryngeal conventional squamous cell carcinomas and SPCs have been reported to be similar. From treatment standpoint, SPC are considered as carcinomas and treated similar to conventional squamous cell carcinomas with initial excision, especially if the tumor has a predominantly exophytic growth [1,3,16]. Radiation therapy is indicated in recurrent tumors or tumors with extensive stromal invasion.…”

Section: Discussionmentioning

confidence: 99%

Spindle Cell Carcinoma of the Larynx with Rhabdomyoblastic Heterologous Element: A Rare Form of Divergent Differentiation

Purgina

Seethala

2012

Head and Neck Pathol

View full text Add to dashboard Cite

Spindle cell (sarcomatoid) carcinoma of the larynx is a rare subtype of squamous cell carcinoma that shows a prominent spindle cell component with a mesenchymal phenotype. Heterologous elements may be seen in these spindled areas and usually consist of osteosarcomatous or chondrosarcomatous differentiation. We describe an unusual spindle cell carcinoma of the vocal cord in a 68 year old male which demonstrated rhabdomyosarcomatous differentiation as confirmed by desmin and myogenin immunoreactivity. Thus rhabdomyosarcomatous differentiation adds to the phenotypic spectrum of spindle cell carcinomas of the larynx and should be considered before invoking a diagnosis of true rhabdomyosarcoma of the larynx.

show abstract

Spindle cell carcinoma of the larynx: Review of 26 cases including DNA content and immunohistochemistry

Cited by 164 publications

References 34 publications

Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

Sarcomatoid (Spindle Cell) Carcinoma of the Head and Neck Mucosal Region: A Clinicopathologic Review of 103 Cases from a Tertiary Referral Cancer Centre

Carcinosarcoma de laringe: Reporte de dos casos

Spindle Cell Carcinoma of the Larynx with Rhabdomyoblastic Heterologous Element: A Rare Form of Divergent Differentiation

Contact Info

Product

Resources

About