Spinal somatostatin superfusion in vivo affects activity of cat nociceptive dorsal horn neurons: Comparison with spinal morphine

Sandkühler, Jürgen; Fu, Q.-G.; Helmchen, C.

doi:10.1016/0306-4522(90)90165-z

Cited by 86 publications

(35 citation statements)

References 39 publications

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“…The result in part contradicts with other reports that SOM is involved in mechanical or heat nociception (Kuraishi et al, 1985;Morton et al, 1989;Song et al, 2002). Nevertheless, it is in concordance with the previous reports that SOM has an inhibitory effect on dorsal horn neurons (Sandkühler et al, 1990;Helmchen et al, 1995;Taddese et al, 1995).…”

Section: Discussioncontrasting

confidence: 59%

“…However, there is contradictory evidence with regards to the role of SOM in modulating the nociceptive transmission in the spinal cord. SOM elicits antinociceptive effects against acute noxious thermal and mechanical stimuli (Sandkühler et al, 1990) and attenuates the hyperalgesia in the formalin and carrageenin-induced inflammation model (Chapman and Dickenson, 1992;Pinter et al, 2002). On the other hand, the intrathecal administration of SOM facilitates the flexion reflex to C-fiber input and noxious thermal stimulation (Seybold et al, 1981;Wisenfield-Hallin, 1985, 1986Morton et al, 1989;Kamei et al, 1993ab).…”

Section: Discussionmentioning

confidence: 99%

“…Sandkühler et al reported that the responses to electrical stimulation of primary afferent Aβ-and Aδ-fibers, were at least not decreased by SOM superfusion, although C-fiber-elicited responses were blocked (Sandkühler et al, 1990). This discrepancy between Sandkühler's and our present results might be due to the difference in drug administration route (iontophoretic application in vivo vs. bath-application in vitro) or the difference of pain modality such as cold-and Aδ-response.…”

Section: Discussionmentioning

confidence: 99%

“…First, SOM exhibits depressant actions on the excitability of neurons, particularly in the spinal cord (Murase et al, 1982;Taddese et al, 1995;Kim et al, 2002;Jiang et al, 2003). Second, SOM superfusion or systemic SOM in vivo inhibits the thermal responses of nociceptive spinal neurons (Sandkühler et al, 1990;Helmchen et al, 1995). Third, intrathecally applied SOM inhibits motor reflexes in response to noxious stimuli and reduces c-Fos expression and mechanical hyperalgesia in neuropathic pain model (Mollenholt et al, 1988;Tsai et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Somatostatin on the Responses of Rostrally Projecting Spinal Dorsal Horn Neurons to Noxious Stimuli in Cats

Jung

Lee

et al. 2008

Korean J Physiol Pharmacol

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Somatostatin (SOM) is a widely distributed peptide in the central nervous system and exerts a variety of hormonal and neural actions. Although SOM is assumed to play an important role in spinal nociceptive processing, its exact function remains unclear. In fact, earlier pharmacological studies have provided results that support either a facilitatory or inhibitory role for SOM in nociception. In the current study, the effects of SOM were investigated using anesthetized cats. Specifically, the responses of rostrally projecting spinal dorsal horn neurons (RPSDH neurons) to different kinds of noxious stimuli (i.e., heat, mechanical and cold stimuli) and to the Aδ -and C-fiber activation of the sciatic nerve were studied. Iontophoretically applied SOM suppressed the responses of RPSDH neurons to noxious heat and mechanical stimuli as well as to C-fiber activation. Conversely, it enhanced these responses to noxious cold stimulus and Aδ -fiber activation. In addition, SOM suppressed glutamate-evoked activities of RPSDH neurons. The effects of SOM were blocked by the SOM receptor antagonist cyclo-SOM. These findings suggest that SOM has a dual effect on the activities of RPSDH neurons; that is, facilitation and inhibition, depending on the modality of pain signaled through them and its action site.

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Somatostatin on the Responses of Rostrally Projecting Spinal Dorsal Horn Neurons to Noxious Stimuli in Cats

Jung

Lee

et al. 2008

Korean J Physiol Pharmacol

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“…Second, activation of SRIF receptors results in inhibition of both nociceptive behaviors in animals (Eschalier et al, 1991;Chapman and Dickenson, 1992;Corsi et al, 1997;Carlton et al, 2001) (but see Hitosugi et al, 1999;Kamei et al, 1999) and acute and chronic pain in humans Meynadier et al, 1985;Plourde et al, 1993;Taura et al, 1994;Paice et al, 1996). Third, SRIF inhibits dorsal horn neuronal activity (Randic and Miletic, 1978;Miletic and Randic, 1982;Murase et al, 1982;Sandkuhler et al, 1990). Finally, SRIF reduces responses of joint mechanoreceptors to noxious rotation of the cat normal knee joint and to both nonnoxious and noxious rotation in the inflamed knee joint (Heppelmann and Pawlak, 1997).…”

Section: Abstract: Primary Afferent; Nociception; Inhibitory Peptidementioning

confidence: 99%

Tonic Control of Peripheral Cutaneous Nociceptors by Somatostatin Receptors

Carlton

Zhou

et al. 2001

J. Neurosci.

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The peptide somatostatin [somatotropin release-inhibiting factor (SRIF)] is widely distributed in the body and exerts a variety of hormonal and neural actions. Several lines of evidence indicate that SRIF is important in nociceptive processing: (1) it is localized in a subset of small-diameter dorsal root ganglion cells; (2) activation of SRIF receptors results in inhibition of both nociceptive behaviors in animals and acute and chronic pain in humans; (3) SRIF inhibits dorsal horn neuronal activity; and (4) SRIF reduces responses of joint mechanoreceptors to noxious rotation of the knee joint. The goal of the present study is to show that cutaneous nociceptors are under the tonic inhibitory control of SRIF. This is accomplished using behavioral and electrophysiological paradigms. In a dose-dependent manner, intraplantar injection of the SRIF receptor antagonist cyclosomatostatin (c-SOM) results in nociceptive behaviors in normal animals and enhancement of nociceptive behaviors in formalin-injected animals, and these actions can be blocked when c-SOM is coapplied with three different SRIF agonists. Furthermore, intraplantar injection of SRIF antiserum also results in nociceptive behaviors. Electrophysiological recordings using an in vitro glabrous skin-nerve preparation show increased nociceptor activity in response to c-SOM, and this increase is blocked by the same three SRIF agonists. Parallel behavioral and electrophysiological studies using the opioid antagonist naloxone demonstrate that endogenous opioids do not maintain a tonic inhibitory control over peripheral nociceptors, nor does opioid receptor antagonism influence peripheral SRIF effects on nociceptors. These findings demonstrate that SRIF receptors maintain a tonic inhibitory control over peripheral nociceptors, and this may contribute to mechanisms that control the excitability of these terminals.

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Neuropeptide receptors in developing and adult rat spinal cord: An in vitro quantitative autoradiography study of calcitonin gene‐related peptide, neurokinins, μ‐opioid, galanin, somatostatin, neurotensin and vasoactive intestinal polypeptide receptors

Kar

Quirion

1995

J of Comparative Neurology

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A number of neuroactive peptides including calcitonin gene-related peptide (CGRP), substance P, neurokinin B, opioids, somatostatin (SRIF), galanin, neurotensin and vasoactive intestinal polypeptide (VIP) have been localized in adult rat spinal cord and are considered to participate either directly and/or indirectly in the processing of sensory, motor and autonomic functions. Most of these peptides appear early during development, leading to the suggestion that peptides, in addition to their neurotransmitter/neuromodulator roles, may possibly be involved in the normal growth and maturation of the spinal cord. To provide an anatomical substrate for a better understanding of the possible roles of peptides in the ontogenic development of the cord, we investigated the topographical profile as well as variation in densities of [125I]hCGRP alpha, [125I]substance P/neurokinin-1 (NK-1), [125I]eledoisin/neurokinin-3 (NK-3), [125I]FK 33-824 ([D-Ala2, Me-Phe4, Met(O)ol5]enkephalin)/mu-opioid, [125I]galanin, [125I]T0D8-SRIF14 (an analog of somatostatin); [125I]neurotensin and [125I]VIP binding sites in postnatal and adult rat spinal cord using in vitro quantitative receptor autoradiography. Receptor binding sites recognized by each radioligand are found to be distributed widely during early stages of postnatal development and then to undergo selective modification to attain their adult profile of distribution during the third week of postnatal development. The apparent density of various receptor sites, however, are differently regulated depending on the lamina and the stage of development studied. For example, the density of mu-opioid binding sites, following a peak at postnatal day 4 (P4), declines gradually in almost all regions of the spinal cord with the increasing age of the animal. [125I]substance P/NK-1 binding sites, on the other hand, show very little variation until P14 and then subsequently decrease as the development proceeds. In the adult rat, most of these peptide receptor binding sites are localized in relatively high amounts in the superficial laminae of the dorsal horn. To varying extents, moderate to low density of various peptide receptor binding sites are also found to be present in the ventral horn, intermediolateral cell column and around the central canal. Taken together, these results suggest that each receptor-ligand system is regulated differently during development and may each uniquely be involved in cellular growth, differentiation and in maturation of the normal neural circuits of the spinal cord. Furthermore, the selective localization of various receptor binding sites in adult rat spinal cord over a wide variety of functionally distinct regions reinforces the neurotransmitter/modulator roles of these peptides in sensory, motor and autonomic functions associated with the spinal cord.

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Spinal somatostatin superfusion in vivo affects activity of cat nociceptive dorsal horn neurons: Comparison with spinal morphine

Cited by 86 publications

References 39 publications

Effects of Somatostatin on the Responses of Rostrally Projecting Spinal Dorsal Horn Neurons to Noxious Stimuli in Cats

Effects of Somatostatin on the Responses of Rostrally Projecting Spinal Dorsal Horn Neurons to Noxious Stimuli in Cats

Tonic Control of Peripheral Cutaneous Nociceptors by Somatostatin Receptors

Neuropeptide receptors in developing and adult rat spinal cord: An in vitro quantitative autoradiography study of calcitonin gene‐related peptide, neurokinins, μ‐opioid, galanin, somatostatin, neurotensin and vasoactive intestinal polypeptide receptors

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