Spinal Extradural Leiomyoma in a Pediatric Patient with Acquired Immunodeficiency Syndrome: Case Report

Choi, Sunju; Levy, M.; Krieger, Gerhard; Jg, McComb

doi:10.1097/00006123-199705000-00038

Cited by 13 publications

(23 citation statements)

References 12 publications

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“…In the reported cases, the intraspinal leiomyomas showed isointensity on T1-weighted images and iso- to hypointensity on T2-weighted images (1,2,6). In certain cases, heterogeneous enhancement, with well-defined tumor margins, was detected following gadolinium administration.…”

Section: Discussionmentioning

confidence: 76%

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Intraspinal leiomyoma: A case report and literature review

Yang

Deng

et al. 2014

Oncology Letters

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Leiomyomas are benign tumors which are predominantly found in the genitourinary and gastrointestinal tracts. Leiomyomas in the spine are extremely rare. The current study presents a case of a 35-year-old female with intraspinal leiomyoma who presented with low back pain and weakness in the left leg of two months. Computerized tomography and magnetic resonance imaging revealed an epidural mass at the T11–12 levels. The patient underwent a T11–12 laminectomy through posterior approach, achieving total removal of the tumor with a well-demarcated dissection plane. Pathological examination demonstrated a leiomyoma. Postoperatively, the patient showed a significant improvement in neurological function. Although intraspinal leiomyoma is extremely rare, it should be considered in the differential diagnosis of spinal lesions in females. The diagnosis is predominantly dependent on a pathological examination. Gross total resection is recommended for its treatment, however the prognosis remains poor. Post-operative hormonal therapy may be useful in controlling tumor recurrence.

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Section: Discussionmentioning

confidence: 76%

“…Leiomyomas account for <2% of soft tissue tumors, with an incidence rate of 8 per million (2). Leiomyomas in the spine are extremely rare, with only eight reported cases of intraspinal leiomyoma (1–8).…”

Section: Introductionmentioning

confidence: 99%

Intraspinal leiomyoma: A case report and literature review

Yang

Deng

et al. 2014

Oncology Letters

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“…Leiomyomas and leiomyosarcomas have been reported to occur in pediatric patients in unusual locations [2]. Recently, primary spinal extradural leiomyomas have been reported in pediatric HIV-positive patients [3]. …”

Section: Differential Diagnosismentioning

confidence: 99%

A 10-Year-Old Boy, HIV Positive, Develops Progressive Weakness

George

Grant

DeLeon³

et al. 1999

Pediatr Neurosurg

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“…There are many published reports of benign metastasizing leiomyoma (BML),[1] but primary extradural leiomyoma is rarely reported. [23] Primary leiomyoma of the bone is more common in the facial bones, and is less common in the skull bones and vertebra. [4] Our report appears to be the first documentation of primary leiomyoma involving the C2 vertebra in an immunocompetent woman without an uterine leiomyoma.…”

Section: Introductionmentioning

confidence: 99%

C2 Primary leiomyoma in an immunocompetent woman: A case report and review of literature

et al. 2017

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Clinical case report and review of the literature. This is the first case of primary leiomyoma in an immunocompetent woman without previous history of uterine leiomyoma being reported in the literature to the best of our knowledge. Leiomyoma, a type of smooth muscle cell tumor, involving the vertebra is extremely rare. There were very few primary leiomyoma in patients with AIDS or in the immune-suppressed patients. This 48-year-old female came with H/o neck pain, weakness and bladder retention. On examination, tone increased in all four limbs, power on the right side of the limbs 4/5, power on the left upper limb 0/5, lower limb 3/5, left plantar was up going, decreased sensation over the left second cervical vertebra (C2) dermatome and all modalities decreased below C2. X-ray and magnetic resonance imaging (MRI) of the cervical spine showed kyphosis of the cervical spine with destruction of the C2 vertebral body along with pathological fracture. The patient underwent decompression of the C2 lesion through the C2 right pedicle with occipito-C1-C3 lateral mass screws fixation. Lesion anterior to the cord was reached by a transpedicular approach and decompression was performed. The lesion was pinkish grey, firm and moderately vascular and was destroying the C2 vertebral body. The patient improved symptomatically in power in the left upper limb and lower limb over the next 1 week duration from 0/5 to 4+/5. Histopathology revealed primary leiomyoma. The patient was evaluated with ultrasound abdomen and contrast tomogram of the chest, abdomen and pelvis to rule out other possible lesions in the lung, intestines and uterus. We suggest that leiomyoma should be included in the differential diagnosis of destructive lytic lesions involving the C2 vertebra. Histopathological examination with immunohistochemistry is necessary for the definitive diagnosis. Treatment of choice is surgery with complete removal.

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Spinal Extradural Leiomyoma in a Pediatric Patient with Acquired Immunodeficiency Syndrome: Case Report

Abstract: With the ever-growing number of pediatric patients with AIDS, the entity will likely be encountered with increasing frequency in the future. Because of the potential for neurological recovery and cure, the neurosurgeon should be cognizant of this entity.

Cited by 13 publications

References 12 publications

Intraspinal leiomyoma: A case report and literature review

Intraspinal leiomyoma: A case report and literature review

A 10-Year-Old Boy, HIV Positive, Develops Progressive Weakness

C2 Primary leiomyoma in an immunocompetent woman: A case report and review of literature

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