Intraspinal leiomyoma: A case report and literature review

Yang, Tao; Wu, Liang; Deng, Xiaofeng; Yang, Chenlong; Zhao, Liang; Xu, Yulun

doi:10.3892/ol.2014.2299

Cited by 5 publications

(23 citation statements)

References 18 publications

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“…Actinomycosis, caused by Actinomyces species, was first described by Israel in 1878 (7). Intraspinal actinomycosis is a very rare disease, and only 29 cases have been reported so far (8,9). The majority of patients with intraspinal actinomycosis are immunocompetent (8).…”

Section: Discussionmentioning

confidence: 99%

“…Intraspinal actinomycosis is a very rare disease, and only 29 cases have been reported so far (8,9). The majority of patients with intraspinal actinomycosis are immunocompetent (8). The disease tends to affect adults, and a male predominance is observed (8).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of patients with intraspinal actinomycosis are immunocompetent (8). The disease tends to affect adults, and a male predominance is observed (8). The dura surrounding the spinal cord is a tight barrier that prefers epidural abscess and granulation tissue formation rather than intrathecal empyema (10).…”

Section: Discussionmentioning

confidence: 99%

“…However, we only found the intrathecal bacterial colony, and the source that the infection disseminated from was unknown. The lungs were the most common initial infected sites of intraspinal actinomycosis, while in more than half of the cases, no infection source was detected (8). Intracranial actinomycosis with undetected sources more often occurred after an unrelated cranial intervention (11).…”

Section: Discussionmentioning

confidence: 99%

“…Intraspinal actinomycosis presents with non-specific manifestations and has an insidious onset. Persistent back pain is usually the initial complaint, and only 65% of patients had a history of fever (8). Local neurological symptoms can indicate involvement of the spinal cord or the nerve root segments.…”

Section: Discussionmentioning

confidence: 99%

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Spinal Intrathecal Actinomycosis Causes Multisegmental Root Failure: A Case Report

et al. 2020

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Actinomycosis is a slowly progressing infection caused by Actinomyces species, which consists of filamentous gram-positive bacteria. Intraspinal actinomycosis is very rare and most of the previous cases presented with epidural lesions. Only two cases of intrathecal actinomycosis have been described. We reported a case of intrathecal actinomycosis in a 46-year-old woman. Our patient presented with multisegmental root failure, which was different from previous intrathecal cases mainly involving the spinal cord. The manifestations, cervical MR imaging results, biopsy and histopathological features, and treatment history of the patient were reviewed. Clinical features of this disease resemble intraspinal neoplasms, other infectious processes, and granulomatous diseases, thus being difficult to diagnose preoperatively. Histopathological evidence from the biopsy is important for timely diagnosis. Early diagnosis and treatment may greatly improve the prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Spinal Intrathecal Actinomycosis Causes Multisegmental Root Failure: A Case Report

et al. 2020

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Upper Cervical Leiomyoma in an Adolescent Male

Dhar¹,

Parikh²,

Gala³

et al. 2022

JOCR

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Introduction:Leiomyomas are benign epithelial tumors with a female preponderance usually in the uterus, gastro-intestinal tract and skin. They are well-capsulated tumors with no mitotic activity and little pleomorphism. Primary leiomyoma in the upper cervical spine region is rare and the occurrence of these lesions in young immunocompetent males is extremely rare. Case Report: A 15-year-old male had swelling over the nape of the neck for 4 years with slight difficulty in neck movements for a few months. Asymptomatic 4 years back be developed a painless swelling at the nape of the neck on the right side initially the size of a pea which gradually increased size. A 10x8cm firm, on-tender and non-pulsatile swelling at the nape of the neck on the right extending from the occipital nuchal line and crossing the midline up to the posterior border of the sternomastoid. The skin over the swelling wasn’t adherent and the swelling did not reduce on neck movements. Neck movements were terminally restricted with restriction on rotation towards the right. Routine X-ray’s and magnetic resonance imaging were suggestive of a soft tissue mass in the inter-muscular plane on the posterior aspect more on the right side with a cystic component and causing thinning of the C2 lamina with no intraspinal extension. Biopsy was done. Findings were suggestive of a spindle cell benign tumor. Posterior en bloc excision was planned and the lesion blog with the entire capsule was excised and sent for histopathology which revealed the lesion was a leiomyoma. The patient has shown no clinical or radiological evidence of recurrence at 4 year fol-low-up. Conclusion: Leiomyomas in the upper cervical spine is extremely rare in adolescent immunocom-petent male. Keywords: Leiomyoma, spine, cervical.

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Leiomyogenic tumor of the spine: surgical treatments and long-term outcomes of 12 consecutive patients

He¹,

Xu²,

Li³

et al. 2020

Journal of Neurosurgery: Spine

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OBJECTIVELeiomyogenic tumor of the spine is rare with limited published information. Here, the authors report the clinical features and long-term surgical outcomes and investigate the prognostic factors affecting disease-free survival (DFS).METHODSTwelve patients presented to the authors’ institution for surgical treatment from January 2005 to December 2018. The clinical characteristics and outcomes were retrospectively reviewed, and the DFS rate was estimated using the Kaplan-Meier method. The log-rank test was used to identify the potential prognostic factors, with p < 0.05 considered statistically significant.RESULTSThe mean patient age was 49.7 ± 12.9 years (range 22–73 years). Four patients underwent marginal en bloc resection, and 8 patients underwent conventional piecemeal resection. Pathological diagnosis revealed leiomyosarcoma in 9 patients and leiomyoma in 3 patients. Three patients had tumor recurrence at a mean follow-up of 10.4 months (range 7.0–15.0 months), while 4 developed metastases at an average of 13.8 months (range 5.5–21.3 months) postoperatively. During the mean follow-up of 33.7 months (range 9.6–78.5 months), the estimated 1- and 5-year DFS rates were 66.7% and 38.2%, respectively. Albumin loss > 20 g/L after surgery, Ki-67 positivity > 10%, and piecemeal resection were correlated with worse DFS.CONCLUSIONSSurgical management of spinal leiomyogenic tumors is challenging due to the high rate of recurrence and metastases. En bloc resection should be performed in eligible patients. Albumin loss > 20 g/L and the Ki-67 index may be independent factors affecting prognosis.

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Intraspinal leiomyoma: A case report and literature review

Cited by 5 publications

References 18 publications

Spinal Intrathecal Actinomycosis Causes Multisegmental Root Failure: A Case Report

Spinal Intrathecal Actinomycosis Causes Multisegmental Root Failure: A Case Report

Upper Cervical Leiomyoma in an Adolescent Male

Leiomyogenic tumor of the spine: surgical treatments and long-term outcomes of 12 consecutive patients

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