Spinal Cοrd Compression Secondary to Brοwn Tumοr as First Manifestation of Primary Hyperparathyroidism

Spinal cord compression caused by a brown tumor secondary to primary hyperparathyroidism

“…Typically, CT imaging documented BTs as well-defined soft-tissue masses with local bony erosion, expansion, while on magnetic resonance imaging studies, these lesions appear hypointense on T1, hypo- or hyperintense on T2-weighted images, with homogenous contrast enhancement. [ 7 - 22 ] The differential diagnoses these spinal lesions included; metastatic tumors, multiple myeloma, plasmacytoma, giant cell tumors, lymphoma, and aneurysmal bone cysts. [ 12 - 18 ]…”

“…Brown tumors (BTs) are rare benign and non-neoplastic lesions that arise secondary to hyperparathyroidism (i.e., primary, or rarely secondary). [6][7][8][9][10][11] ey most commonly involve the mandible, ribs, pelvis, and large bones, and only rarely the spine. [7] Here, a T3-T5 thoracic BT, arising secondary to hyperparathyroidism, contributed to cord compression and a paraparetic deficit that resolved following decompressive surgery.…”

Brown tumor due to primary hyperparathyroidism resulting in acute paraparesis: Case report and literature review

“…[6] Twenty-five similar cases of spinal brown tumors due to primary hyperparathyroidism have been described in the literature (e.g., 1968 to the present) [Table 1]. [1][2][3][4][5][6][7][8][9][10] Patients typically range from 16 to 69 years of age, and more females than males are impacted (e.g., 15 females vs. 10 males). e most common location for brown tumors is the thoracic spine where presenting symptoms/signs typically range from back pain/ radiculopathy, to myelopathy with paralysis with/without sphincter disturbances.…”

“…[4] However, for patients presenting with significant spinal cord compression due to brown tumors, immediate operative decompression/ stabilization may be necessary, followed secondarily by resection of parathyroid adenomas. [1,3,5,8,9] For the case presented, the patient's initial significant paraparesis due to the T4-T5 largest compressive spinal lesions warranted operative decompression, both to reverse the neurological deficit/paraparesis, and provide a tissue-diagnosis.…”

“…[8] ese lesions are typically found in the mandible, pelvis, ribs, and large bones; only rarely do they involved the axial spine. [3] ey are called brown tumors due to their high hemosiderin content. e term osteitis fibrosa cystica reflects their intrinsic peri trabecular bone fibrosis (osteitis fibrosa), and increased osteoclastic activity causing lytic bone lesions.…”