“…5 However, the irreversible morphofunctional changes in the microcirculatory system in patients with CLI may not bring about the desired result after SCS. 23 Thus, according to our findings, a combination of low tissue metabolism values (restTcPO 2 <10 mm Hg) and an abrupt disruption of the adaptive mechanisms of the microvasculature presenting as a lack of increase in the level of transcutaneous oxygenation during the orthostatic test negatively affected the clinical dynamics after SCS. Accordingly, the adaptive increase in the standTcPO 2 value by more than 10 mm Hg was associated with the positive clinical dynamics after SCS.…”