Spinal Cord Ischemia after Endovascular Repair of the Descending Thoracic Aorta in a Sheep Model

Böckler, Dittmar; Kotelis, Drosos; Kohlhof, Patricia; Tengg-Kobligk, Hendrik von; Mansmann, Ulrich; Zink, Wolfgang; Hörner, Christian; Ortlepp, I.; Habel, Antje; Kauczor, HU; Graf, Bernhard M.; Allenberg, J.-R.

doi:10.1016/j.ejvs.2007.04.030

Cited by 21 publications

(6 citation statements)

References 51 publications

(34 reference statements)

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“…14 In an animal model, Böckler et al demonstrated that endovascular repair is associated with lower rates of spinal cord ischaemia and paraplegia than aortic cross-clamping. 29 These findings were confirmed in human by Carroccio et al 30 This hypothetical advantage was likely balanced in our series by the increased risk of spinal cord ischaemia related to the high incidence of prior descending, abdominal or thoraco-abdominal aortic graft repairs in the patients we selected for hybrid TAAA repair. 25 However, the problem of paraplegia has not been eliminated by hybrid TAAA repair and extensive coverage of the thoracoabdominal aorta could be identified as the cause of a still significant rate of spinal cord complications.…”

Section: Spinal Cord Ischaemiasupporting

confidence: 80%

Is Hybrid Procedure the Best Treatment Option for Thoraco-Abdominal Aortic Aneurysm?

Chiesa

Tshomba

Melissano

et al. 2009

European Journal of Vascular and Endovascular Surgery

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Typical complications of conventional TAAA open surgery have been not eliminated by hybrid repair and significant mortality and morbidity have been reported till date. The fate of visceral bypasses and incidence of endoleak and other endograft-related complications need to be carefully assessed. Hybrid TAAA repair should nowadays be limited as alternative to simple observation in patients unfit for the conventional open repair.

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Section: Spinal Cord Ischaemiasupporting

confidence: 80%

Is Hybrid Procedure the Best Treatment Option for Thoraco-Abdominal Aortic Aneurysm?

Chiesa

Tshomba

Melissano

et al. 2009

European Journal of Vascular and Endovascular Surgery

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“…There are numerous reports of the use of the sheep model to study spinal cord injury. Kaplan [32], Moomiaie [33], and Bockler [34] describe the use of the sheep model for detecting interruption of spinal cord blood flow during aortic cross-clamping. Numerous reports exist for the testing of the epidural approach for anesthesia and for attempts at protecting against spinal ischemia in sheep [35-39].…”

Section: Methodsmentioning

confidence: 99%

Optical Monitoring and Detection of Spinal Cord Ischemia

et al. 2013

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Spinal cord ischemia can lead to paralysis or paraparesis, but if detected early it may be amenable to treatment. Current methods use evoked potentials for detection of spinal cord ischemia, a decades old technology whose warning signs are indirect and significantly delayed from the onset of ischemia. Here we introduce and demonstrate a prototype fiber optic device that directly measures spinal cord blood flow and oxygenation. This technical advance in neurological monitoring promises a new standard of care for detection of spinal cord ischemia and the opportunity for early intervention. We demonstrate the probe in an adult Dorset sheep model. Both open and percutaneous approaches were evaluated during pharmacologic, physiological, and mechanical interventions designed to induce variations in spinal cord blood flow and oxygenation. The induced variations were rapidly and reproducibly detected, demonstrating direct measurement of spinal cord ischemia in real-time. In the future, this form of hemodynamic spinal cord diagnosis could significantly improve monitoring and management in a broad range of patients, including those undergoing thoracic and abdominal aortic revascularization, spine stabilization procedures for scoliosis and trauma, spinal cord tumor resection, and those requiring management of spinal cord injury in intensive care settings.

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“…An important treatment for this injury is intradural or epidural spinal cord stimulation using electrodes to alleviate post-SCI chronic pain and spasticity. Sheep have been used to test the efficacy and safety of these implantable devices [91,92] . Several factors require consideration: proximity to the stimulation area, magnitude of the stimuli, durability and longevity of the device, and prevention of ischemic effects due to pressure from the device [91,92] .…”

Section: Spinal Cord Injurymentioning

confidence: 99%

A one-health approach to using sheep in research, with a focus on neuroscience studies

Chatzimanou,

Tsingotjidou

2023

One Health Implement Res

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Sheep have been an important animal for both academic and basic sciences education, with a positive impact on the public health sector and, subsequently, One Health. This review presents the impact of sheep on research with a specific focus on neuroscience studies. Disorders, as well as neuroendocrine and environmental factors affecting the brain, the spinal cord, and the peripheral nervous system, are selected, and relevant research and sheep models mimicking human diseases are described. The review discusses various sheep models, encompassing prion, Parkinson’s, Alzheimer’s, Huntington’s disease, and neuronal ceroid lipofuscinoses (Batten Disease), along with ischemic stroke. Sheep play a pivotal role in elucidating the pathogenesis and/or treatment for the aforementioned diseases. Furthermore, this research is underpinned by solid neuroanatomy knowledge. Consequently, we outline the main reasons why sheep are such robust research models. In conclusion, we demonstrate the important role that sheep models fulfill in advancing the mission of the One Health Initiative.

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Spinal Cord Ischemia after Endovascular Repair of the Descending Thoracic Aorta in a Sheep Model

Cited by 21 publications

References 51 publications

Is Hybrid Procedure the Best Treatment Option for Thoraco-Abdominal Aortic Aneurysm?

Is Hybrid Procedure the Best Treatment Option for Thoraco-Abdominal Aortic Aneurysm?

Optical Monitoring and Detection of Spinal Cord Ischemia

A one-health approach to using sheep in research, with a focus on neuroscience studies

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