Spinal canal narrowing during simulated frontal impact

Ivancic, Paul C.; Panjabi, Manohar M.; Tominaga, Yoshihiro; Pearson, Adam M.; Gimenez, S Elena; Maak, Travis G.

doi:10.1007/s00586-005-0985-4

Cited by 9 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite this, fracture-dislocation is relatively understudied injury mechanism in experimental SCI research. The geometric variable most relevant to AP cervical dislocation is CPD, and changes in this variable have been assessed during simulated frontal and rear impacts (Ito et al, 2004;Ivancic et al, 2006). Using 3-month old Sprague-Dawley rats, Choo et al (2009) classified a 2.6-mm dislocation as moderate-to-severe with a mortality rate of 10%.…”

Section: Discussionmentioning

confidence: 99%

“…Second, despite our best efforts, we were unable to remove all of the vertebral column extension in our specimens. The importance of this issue is highlighted by findings that spine flexion/extension induced by dynamic front and rear impacts can result in a narrowing of CPD in the cervical spine (Ito et al, 2004;Ivancic et al, 2006). However, we feel this will have a limited influence on our findings as we used a standard mounting technique across all specimens, and pilot results from a single specimen (see ''Tissue specimens'' section) indicated that vertebral column extension during our static fixation had minimal influence on our microCT geometry measures.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, their experimental protocol did not allow for the calculation of several important variables that influence spinal cord injury and cervical myelopathy. Specifically, by separating each vertebra and removing all soft tissues during dissection, variables measured across vertebral segments [e.g., canal pinch diameter (CPD) (Ivancic et al, 2006)] and markers of spine degeneration (including osteophyte development and changes to the intervertebral disc) could not be quantified. An important unanswered question is whether such morphometric measures would differ as a function of age in adult rats.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Advanced Age on the Morphometry and Degenerative State of the Cervical Spine in a Rat Model

Laing

Cox

Tetzlaff

et al. 2011

The Anatomical Record

View full text Add to dashboard Cite

Aging causes changes in the geometry of the human cervical spine that may influence the tissue response to applied loads. Rat models are often used to study spinal cord injuries (SCI) and have the potential to enhance our understanding of the effect of age on SCI. The goal of this study was to characterize the morphometry and degenerative state of the cervical spine in Fisher 344 rats, and to determine the influence of age on these variables. Fifteen rats were split into three age groups: young adult (3 months of age), aged (12-18 months) and geriatric (30 months). Following tissue harvest we used a lCT scanner to image the cervical and upper thoracic spine from each specimen. Analysis software was used to measure variables including canal pinch diameter (the most rostral point on the dorsal aspect of a vertebral body to the most caudal aspect of the lamina on the immediately rostral vertebra), vertebral canal depth, width, and area, vertebral body height, depth, width, and area, and intervertebral disc thickness. Orthopaedic surgeons used midsagittal images to rate the degenerative state of the intervertebral discs. For all measures except disc thickness there was a significant increase (mean (SD) ¼ 15.0 (9.7)%) for the aged compared to young specimens (P < 0.05). There were significant differences between the aged and geriatric specimens for only vertebral body depth (P ¼ 0.016) and area (P ¼ 0.020). Intervertebral disc degeneration was significantly greater on the ventral aspect of the spinal column (P < 0.001), with a trend toward increased degeneration in the geriatric specimens (P ¼ 0.069). The results suggest that agerelated morphometric differences may need to be accounted for in experimental aging models of SCI in rats. Anat Rec, 294:1326Rec, 294: -1336Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Advanced Age on the Morphometry and Degenerative State of the Cervical Spine in a Rat Model

Laing

Cox

Tetzlaff

et al. 2011

The Anatomical Record

View full text Add to dashboard Cite

show abstract

“…Proposed segmental kinematics have also been described for frontal collision vectors [101,102], confirming that these mechanisms of injury also demonstrate the potential to result in cervical spine injury.…”

Section: Upper Cervical Flexionmentioning

confidence: 57%

Whiplash associated disorders: A prospective investigation of the effects of cervical medial branch radiofrequency neurotomy on sensory, motor and psychological Features

Smith¹

View full text Add to dashboard Cite

Whiplash injury results in persistent pain and disability for a significant number of individuals. Clinically, these individuals present with a complex presentation of physical features (including central hyperexcitability and motor dysfunction) and psychological manifestations (e.g. psychological distress, pain catastrophization and posttraumatic stress symptoms) that may be resistant to conservative care. Understanding this complex symptom presentation is made challenging by the inability of current diagnostic imaging techniques to clearly identify potential pathoanatomical causes for these symptoms. Nevertheless, anatomical structures contributing to chronic whiplash associated disorders (WAD) have been identified in clinical and basic science research. These results provide further knowledge of processes underlying chronic WAD. The finding that peripheral nociception is one of the drivers of central hyperexcitability, motor dysfunction and psychological manifestations in chronic WAD is a vital step forward towards more effective management for this difficult patient group, allowing healthcare providers to provide patients with appropriate treatment options, especially when conservative therapy has failed.

show abstract