Spinal aneurysmal bone cyst in children: systematic review of the literature

Naumov, Denis; Сперанская, Елена Александровна; Мушкин, М. А.; Malamashin, Denis; Мушкин, Александр Юрьевич

doi:10.14531/ss2019.2.49-55

Hir. pozvonoč.

2019

DOI: 10.14531/ss2019.2.49-55

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Spinal aneurysmal bone cyst in children: systematic review of the literature

Denis Naumov

Елена Александровна Сперанская

М. А. Мушкин

et al.

Abstract: Publications on aneurysmal bone cysts of the spine in children for the last 20 years were systematized taking into account different treatment approaches. The results of radiation therapy, local puncture interventions, surgical removal of the tumor, selective embolization, and of their combinations were reviewed based on the data of 19 publications representing 165 pediatric patients.

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Aneurysmal bone cysts therapy using monoclonal human antibodies to RANKL

Abdiba,

Pozdeev,

Chigvarya

et al. 2024

N.N. Priorov Journal of Traumatology and Orthopedics

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Aneurysmal bone cyst is a rare, locally destructive, benign neoplasm with a predominant localization in the bones. Aneurysmal bone cyst accounts for 1%–6% of primary bone tumors, and 80% of these lesions occur in the second decade of life with a slight prevalence in the female population. Currently, the optimal aneurysmal bone cyst treatment remains unclear. There are various treatment methods, each of which has its own indications, advantages, and disadvantages. The study of the key pathogenetic foundations of the process indicates the introduction of targeted aneurysmal bone cyst therapy. This study presents the systematized classification and description of the disease pathogenesis regarded from molecular and genetic viewpoints. The mechanism of targeted therapy based on the use of monoclonal human antibodies to RANKL has been studied. Articles published in 2012–2023 (July) were considered. Consequently, conclusions concerning the most common aneurysmal bone cyst localizations, patient’s age and sex, dosage regimen, treatment result, and possible complications during the therapy have been made. Thus, denosumab has therapeutic advantages regarding clinical and radiological results in patients with aneurysmal bone cyst. Closely relevant is the issue of using denosumab in the treatment of patients with aneurysmal bone cyst of complex anatomical localization and in cases of aggressive recurrence of the pathological process.

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Aneurysmal bone cysts therapy using monoclonal human antibodies to RANKL

Abdiba,

Pozdeev,

Chigvarya

et al. 2024

N.N. Priorov Journal of Traumatology and Orthopedics

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Surgery features of aneurysmal bone cysts of the spine in children

Snetkov

Gamayunov

Kuleshov

et al. 2021

N.N. Priorov Journal of Traumatology and Orthopedics

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The article presents the long-term experience of stepwise surgical treatment of pediatric patients with aneurysmal cysts of the spine. The considered material is based on the data of long-term results and various approaches to the resection technique of pathological neoplasm; each approach takes into account the localization, lesion volume, spine growth potential, neurological status, secondary spinal deformity.

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Spinal aneurysmal bone cyst in children: systematic review of the literature

Cited by 2 publications

References 30 publications

Aneurysmal bone cysts therapy using monoclonal human antibodies to RANKL

Aneurysmal bone cysts therapy using monoclonal human antibodies to RANKL

Surgery features of aneurysmal bone cysts of the spine in children

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