In Spring 2005, the blazar 3C 454.3 underwent a dramatic outburst at all wavelengths from mm to X-rays. This prompted INTEGRAL observations, accomplished in 15−18 May 2005. The source was detected by the INTEGRAL instruments from 3 to 200 keV in a bright state (∼5 × 10 −10 erg s −1 cm −2 ), at least a factor of 2−3 higher than previously observed. This is one of the brightest blazar detections achieved by INTEGRAL. During the 2.5 days of INTEGRAL monitoring, we detected a ∼20% decrease in the hard X-rays (20−40 keV), indicating that we have sampled the decaying part of the flare. The decrease is less apparent in the soft X-rays (5−15 keV). The simultaneous optical variations are weakly correlated with those at soft X-rays, and not clearly correlated with those at hard X-rays. The spectral energy distribution exhibits two components, as typically seen in blazars, which can be modeled with synchrotron radiation and inverse Compton scattering occurring in a region external to the broad line region.