SPI/PEO blended electrospun martrix for wound healing

Thirugnanaselvam, M.; Nallathambi, Gobi; Karthick, S.

doi:10.1007/s12221-013-0965-y

Cited by 41 publications

(30 citation statements)

References 11 publications

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“…26 A cylindrical beaker lled with 15 mL of de-ionized water and sealed with the test membrane at the top was placed in environmental chamber at 37 C and 40 AE 2% relative humidity as per the standard. 26 A cylindrical beaker lled with 15 mL of de-ionized water and sealed with the test membrane at the top was placed in environmental chamber at 37 C and 40 AE 2% relative humidity as per the standard.…”

Section: Water Vapor Transmission Rates (Wvtr)mentioning

confidence: 99%

Nitrofurazone-loaded electrospun PLLA/sericin-based dual-layer fiber mats for wound dressing applications

Zhao

Sun

et al. 2015

RSC Adv.

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The ideal wound dressing should achieve rapid healing with hemostasis, antimicrobial activity, maintenance of a moist wound bed, etc. The electrospun blend mat meets the requirements outlined for wound healing, by their microfibrous structures providing a suitable environment for wound healing. In this study, a duallayer nanofiber blend mat wound dressing of nitrofurazone (NFZ)-loaded poly(L-lactide) (PLLA)/sericin nanofibers and NFZ-loaded PLLA nanofibers is fabricated by electrospinning. The NFZ-loaded PLLA/ sericin nanofibers act as the first layer and then the NFZ-loaded PLLA nanofibers are the second layer to prepare the dual-layer fiber dressings. The prepared dual-layer NFZ-loaded fiber dressings have satisfactory antibacterial activity against both Gram-positive and Gram-negative bacteria. In vitro drug release studies show that the drug release profiles can be controlled by adjusting the drug amount in different layers of the dual-layer dressings. The methyl thiazolyl tetrazolium (MTT) assays demonstrate that the NFZ-loaded PLLA/sericin fibers are nontoxic and biocompatible. In vivo wound healing tests are performed in rats. The results reveal that the dual-layer fiber dressings perform better than commercial non-woven dressing in decreasing wound size. It is observed at 12 days that the wound size reduction is 97% for being dressed with the dual-layer fiber dressings but 84% for the commercial woven dressing.These NFZ-loaded PLLA/sericinkPLLA dual-layer fiber mats may provide a promising candidate for accelerating wound healing.

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Section: Water Vapor Transmission Rates (Wvtr)mentioning

confidence: 99%

Nitrofurazone-loaded electrospun PLLA/sericin-based dual-layer fiber mats for wound dressing applications

Zhao

Sun

et al. 2015

RSC Adv.

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“…In recent years, biomaterials derived from vegetable proteins have attracted enormous attention as a critical component in functional polymer blends, with intended applications for commodity products, electronics, biomedical, and bio‐engineering applications, etc. Soy protein, as one of the low cost and abundant natural resources, have been widely studied.…”

Section: Introductionmentioning

confidence: 99%

Effective structure regulation of poly(vinylidene fluoride) via soy protein isolate: A morphological study

Zheng¹,

Cox²,

Li³

2018

J of Applied Polymer Sci

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The microstructures of poly(vinylidene fluoride) (PVDF)/soy protein isolate (SPI) films were successfully modulated via denatured SPIs. While vegetable proteins have been extensively researched as functional biomaterials in fabrication of polymer blends, the diverse polymer‐protein interactions because of complex protein structures have not received sufficient attention. In this study, the PVDF‐SPI interactions were tuned by different denaturation treatments including heat, sonication, and chemical denaturation by 2‐mercaptoethanol and sodium dodecyl sulfate, respectively. Phase morphologies, crystal structures of PVDF, and secondary structures of SPI were analyzed by scanning electron microscope, fluorescence imaging, X‐ray diffraction, and Fourier transformed infrared spectroscopy. While 90 °C denaturation and sodium dodecyl sulfate led to nonporous structures, all other denatured SPIs produced distinctive porous structures. The crystallinity of PVDF was reduced to different degrees, depending on the denaturation of SPI. The distinctive microstructures of PVDF/SPI films indicated the diversity of PVDF‐SPI interactions and its importance in functional polymer/protein blends. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 134, 46706

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“…Soy protein was also reported to be used as modifier to improve the biodegradation performances of traditional polymers, like poly(lactic acid) . Besides, soy protein, blending with other polymers, was studied as wound dressing materials . While these studies addressed the importance of polymer–protein compatibility to various performances, most of them did not pay much attention to the aggregated protein structures affected by different denaturation and modification processes.…”

Section: Introductionmentioning

confidence: 99%

“…This study aims at demonstrating varied polymer‐protein interactions and their remarkable effects on structures and functionalities of polymer/protein blends, as a result of different aggregated protein structures tuned by different denaturation processes. Soy protein isolate (SPI), a high protein content (>90%) soy product, was used to study its interactions with poly(ethylene oxide) (PEO), with which protein materials have been frequently compounded . PEO, a semi‐crystalline, polar, and hydrophilic polymer, has been studied for broad applications in drug delivery, wound healing, polymer electrolytes, electronics, and so on.…”

Section: Introductionmentioning

confidence: 99%

Study of denaturation and composition‐dependent poly(ethylene oxide)–soy protein interactions: Structures and dielectric polarization

Zheng

Rashidi

et al. 2018

J of Applied Polymer Sci

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The significance of aggregated protein structures in tuning structures and dielectric polarization of poly(ethylene oxide) (PEO)/soy protein isolate (SPI) films was studied. The aggregated protein structures, subjected to denaturation processes, are expected to alter polymer–protein interactions, leading to diverse material structures, and properties. However, this is still insufficiently understood. In this study, SPI was modified via different denaturation processes including heat, sonication, and pH‐control. According to structural analysis with scanning electron microscope, fluorescence imaging, X‐ray diffraction, and Fourier transformed infrared spectroscopy, both denaturation conditions and SPI content affected PEO–SPI interactions, producing distinctive microstructures of PEO and SPI phases, which subsequently caused different dielectric properties in ferroelectric analysis. Particularly, sonication treated‐SPI distinguished itself by generating a unique parabolic‐like composition dependence of dielectric polarization, in contrast to other modified SPIs. Polymer/protein blends have shown great potential in biomedical and electronic applications, which will be further benefited by the findings in this study. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46561.

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SPI/PEO blended electrospun martrix for wound healing

Cited by 41 publications

References 11 publications

Nitrofurazone-loaded electrospun PLLA/sericin-based dual-layer fiber mats for wound dressing applications

Nitrofurazone-loaded electrospun PLLA/sericin-based dual-layer fiber mats for wound dressing applications

Effective structure regulation of poly(vinylidene fluoride) via soy protein isolate: A morphological study

Study of denaturation and composition‐dependent poly(ethylene oxide)–soy protein interactions: Structures and dielectric polarization

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