Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo

Ceramide production associated with retinal apoptosis after retinal detachment

“…Ovaries treated with S1P kept a normal distribution of follicles and had no genetic abnormalities. The same effect has been observed with chemotherapy-induced apoptosis [47]. Spermatogenesis can also be protected from radiation-induced apoptosis by injecting local S1P [48].…”

In vitro evaluation of the anti-apoptotic drug Z-VAD-FMK on human ovarian granulosa cell lines for further use in ovarian tissue transplantation

“…In the field of fertility preservation, sphingosine-1-phosphate (S1P) and its agonists are largely studied for their combined anti-apoptotic and pro-angiogenic properties. While the ability of S1P to protect follicles from chemotherapy and radiationinduced damages has been well demonstrated [25][26][27][28][29], the protective effects of S1P in cryopreserved tissue grafting studies remain controversial [30][31][32][33]. Another alternative, a permeable synthetic peptide pan-caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (Z-VAD-FMK), has only been studied once in a xenograft model of cryopreserved ovarian tissue after producing encouraging results as a therapeutic option [34].…”

Dose-Dependent Effect of Sphingosine-1-Phosphate in Mouse Oocyte Maturation Medium on Subsequent Embryo Development

“…Other researchers demonstrated that in vivo administration of S1P could protect the ovaries from radiotherapy-induced damage [17,22,23] and even chemotherapy-induced reduction of primordial follicles [24]. Radiation acts directly on the plasma membrane of several cell types, activating acid sphingomyelinase, which generates ceramide by enzymatic hydrolysis of sphingomyelin.…”