Sphingomonas paucimobilis outbreak in a dialysis room: Case report and literature review of an emerging healthcare associated infection

Bavaro, Davide Fiore; Mariani, Michele Fabiano; Stea, Emma Diletta; Gesualdo, Loreto; Angarano, Gioacchino; Carbonara, Sergio

doi:10.1016/j.ajic.2020.01.018

Cited by 18 publications

(22 citation statements)

References 10 publications

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“…Hospital-acquired infections cause significant problems due to higher morbidity, mortality, and increased institutional and financial burden compared to community-acquired infections (5).…”

Section: Discussionmentioning

confidence: 99%

“…This situation brought to mind the possibility of biofilm formation in the plumbing pipes (6). Sphingomonas can form a dense biofilm on colonized surfaces and can accumulate very strong and sticky exopolymers (5). We also experienced that it is easier to isolate water samples in blood culture bottles, which we attributed to the low bacterial density.…”

Section: Accepted Manuscriptmentioning

confidence: 95%

“…This microorganism is found abundant in nature and can be found in soil and water thereby community or hospital-acquired S. paucimobilis infections may arise (1,4). The source of nosocomial infections of S. paucimobilis may be endogenous (previous colonization of the patient), environmental (various medical devices), or contamination of sterile fluids in hospitals (5). The source of the infection may also be biofilm formation in the water distribution systems of the hospitals (6).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Some countries, such as Turkey and Taiwan, should be particularly cautious when it comes to S. paucimobilis because of the high temperatures throughout the summer months. Table 2 shows detailed demographic information about the patients, as well as the infection's focus (1,2,4,5,8,11,12,15,17,20,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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<i>Sphingomonas paucimobilis</i> Outbreak a Pediatric Hematology-Oncology Hospital: Epidemiological Investigation and Literature Review of an Emerging Healthcare-Associated Infection

et al. 2022

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Sphingomonas paucimobilis is an aerobic, nonfermentative, opportunistic Gram-negative bacilli, and can be found in water systems. This study was conducted for analyzing concurrent S. paucimobilis bacteraemia cases and treatment outcomes, investigation of potential outbreak sources, and antimicrobial resistance profiles. This was an ambidirectional cohort study conducted in a 30-bed pediatric haematology/oncology hospital. Patient ages ranged from 1 to 17 years, with a median age of 5 years. Environmental sampling for outbreak source investigation was applied. Bacterial identification and antimicrobial susceptibility tests of isolated bacteria were done using the disk diffusion method and the Vitek®2 automated system. S. paucimobilis was detected in a total of 181 blood culture samples of 51 patients over two years and was isolated from hot tap water. 66% of patients were followed up with the diagnosis of Acute lymphoblastic leukemia (ALL) and two of our patients with ALL died due to S. paucimobilis sepsis. S. paucimobilis isolates were generally susceptible to carbapenems and quinolones.Surveillance and epidemic control should be done for hospital-acquired infectious agents such as S. paucimobilis. Water distribution systems should be checked against colonizing agents at regular intervals.

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“…Hospital-acquired infections cause significant problems due to higher morbidity, mortality, and increased institutional and financial burden compared to community-acquired infections (5).…”

Section: Discussionmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 95%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

See 2 more Smart Citations

<i>Sphingomonas paucimobilis</i> Outbreak a Pediatric Hematology-Oncology Hospital: Epidemiological Investigation and Literature Review of an Emerging Healthcare-Associated Infection

et al. 2022

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“…Sphingomonas paucimobilis, an emergent pathogenic bacterium is aerobic, motile, non-fermenting Gram-negative bacilli. It is being implicated as growing cause of health care associated infections in hospitals in recent years (1). It is catalase and oxidase-positive and also exhibits the production of a yellow pigment (2).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Sphingomonas paucimobilis as an emerging nosocomial pathogen in a teaching hospital in Uttarakhand

Rohilla¹,

Raina²,

Singh³

et al. 2021

IJM

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Background and Objectives: Sphingomonas paucimobilis is an opportunistic pathogen and was rarely encountered in clin- ical specimens previously. This study aimed to investigate the clinical features, associated co-morbidities, and antimicrobial susceptibility patterns of S. paucimobilis infection in a tertiary hospital in Uttarakhand. Materials and Methods: S. paucimobilis isolates cultured from various sections of hospital and OPDs were identified and an- alyzed for their antibiograms in the microbiology laboratory for a duration of one year from January 2020 to December 2020. Results: S. paucimobilis was isolated from 49 samples (0.01%) out of 3792 samples processed in VITEK 2 Compact auto- mated ID/AST instrument. The maximum number of isolates were obtained from urine samples (31%), followed by blood (24%). Septicemia (41%), meningitis (17%), lower respiratory tract infections and ventilator associated pneumonia (14%) constituted a major portion of infections caused by this organism. Diabetes mellitus (22%) and steroid usage (16%) were major associated co-morbid conditions. Third and Fourth generation cephalosporins like ceftriaxone (81%) and cefepime (86%) were found to be the most susceptible drugs whereas 61% of isolates were resistant to colistin. Conclusion: This organism is an up-and-coming pathogen and should not be simply labeled as a contaminant. Although the organism is not grossly virulent and still might not be associated with serious life-threatening infections; however their evolving resistance patterns and increased spectrum of infections should be seriously taken into account.

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Isolation of Sphingomonas paucimobilis from an ocular infection and identification using ribosomal RNA gene: First case report from Iran

Kelishomi

Mohammadi

Khakpoor

et al. 2023

Clinical Case Reports

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Sphingomonas paucimobilis outbreak in a dialysis room: Case report and literature review of an emerging healthcare associated infection

Cited by 18 publications

References 10 publications

<i>Sphingomonas paucimobilis</i> Outbreak a Pediatric Hematology-Oncology Hospital: Epidemiological Investigation and Literature Review of an Emerging Healthcare-Associated Infection

<i>Sphingomonas paucimobilis</i> Outbreak a Pediatric Hematology-Oncology Hospital: Epidemiological Investigation and Literature Review of an Emerging Healthcare-Associated Infection

Evaluation of Sphingomonas paucimobilis as an emerging nosocomial pathogen in a teaching hospital in Uttarakhand

Isolation of Sphingomonas paucimobilis from an ocular infection and identification using ribosomal RNA gene: First case report from Iran

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