Spherical Bioactive Glass with Enhanced Rates of Hydroxyapatite Deposition and Hemostatic Activity

Ostomel, Todd A.; Shi, Qi; Tsung, Chia‐Kuang; Liang, Hongjun; Stucky, Galen D.

doi:10.1002/smll.200600177

Cited by 228 publications

(211 citation statements)

References 44 publications

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“…Bioactive glasses can also serve as vehicle for the local delivery of selected ions being able to control specific cell functions [30,[57][58][59][60][61][62][63][64]. For example, mesoporous BG microspheres have demonstrated enhanced haemostatic activity, as well as reduced clot detection times and increased coagulation rates compared to nonporous microspheres [65]. The release of calcium ions is believed to be responsible for its haemostatic properties [65].…”

Section: Figurementioning

confidence: 99%

“…For example, mesoporous BG microspheres have demonstrated enhanced haemostatic activity, as well as reduced clot detection times and increased coagulation rates compared to nonporous microspheres [65]. The release of calcium ions is believed to be responsible for its haemostatic properties [65]. Moreover, ferromagnetic bioactive glasses and glass-ceramics containing magnetite are being currently developed for hyperthermia treatment of cancer [19,[66][67][68][69].…”

Section: Figurementioning

confidence: 99%

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Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Chatzistavrou

2011

Bioactive Glasses

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Traditionally, bioactive glasses have been used to fill and restore bone defects. More recently, this category of biomaterials has become an emerging research field for bone tissue engineering applications. Here, we review and discuss current knowledge on porous bone tissue engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures. Starting with an excerpt on the history of bioactive glasses, as well as on fundamental requirements for bone tissue engineering scaffolds, a detailed overview on recent developments of bioactive glass and glass-ceramic scaffolds will be given, including a summary of common fabrication methods and a discussion on the microstructural-mechanical properties of scaffolds in relation to human bone (structure-property and structure-function relationship). In addition, ion release effects of bioactive glasses concerning osteogenic and angiogenic responses are addressed. Finally, areas of future research are highlighted in this review.

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Chatzistavrou

2011

Bioactive Glasses

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“…[29,30] Furthermore, mesoporous bioactive glass particles have also exhibited haemostatic activity under in vitro conditions. [31] Although bioactive glasses (microsize and nanosize), especially Bioglass®, have been incorporated into PHAs, these have been mainly scl-PHAs, in order to develop composites with focus on bone tissue engineering and drug delivery applications. [25,32] In this study therefore we sought to investigate, for the first time, the potential of a novel nanocomposite system of poly(3-hydroxyoctanoate), a promising new biodegradable and biocompatible natural polymer, with bioactive glass nanoparticles (nBG) as a unique matrix support for skin tissue engineering applications.…”

Section: Introductionmentioning

confidence: 99%

Highly elastomeric poly(3-hydroxyoctanoate) based natural polymer composite for enhanced keratinocyte regeneration

Rai

Roether

Knowles

et al. 2017

International Journal of Polymeric Materials and Polymeric Biom

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A novel nanocomposite material which combines the biocompatible, elastomeric, natural, biodegradable homopolymer, poly(3-hydroxyoctanoate), P(3HO), with haemostatic and antibacterial bioactive glass nanoparticles (n-BG), were developed as a matrix for skin related applications. P(3HO) is a unique member of the family of natural polyhydroxyalkanoate biopolymers. The P(3HO)/n-BG composite films were fabricated using the solvent casting method. Microstructural studies revealed n-BG particles both embedded in the matrix and deposited on the surface which introduced nanotopography and increased its hydrophilicity.The composite exhibited an increase in the Young's modulus when compared to the control, yet maintained flexible elastomeric properties. These changes in the surface topography and chemistry of the composite system led to an increase of protein adsorption and cytocompatibility for the seeded human keratinocyte cell line (HaCaT). The results from this study demonstrated that the fabricated P(3HO)/n-BG composite system is a promising novel matrix material with potential applications in skin tissue engineering and wound healing.

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“…The substantial advantages of systems containing nanoscale bioactive glass have been demonstrated in recent publications. [1][2][3] The nanometric particles have high surface areas and can form an interface that performs better when composited with porous polymer matrix. Introducing an appropriate percentage of nanometric bioactive glass particles in polymeric materials can increase the mechanical strength of the polymeric material.…”

Section: Introductionmentioning

confidence: 99%

3d Nanocomposite Chitosan/Bioactive Glass Scaffolds Obtained Using Two Different Routes: An Evaluation of the Porous Structure and Mechanical Properties

2016

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Porous synthetic substrates are developed through tissue engineering technologies to grow new tissue, restoring the function of tissue or an organ. For bone regeneration, these scaffolds must support the dynamic load exerted on this tissue, achieved primarily by increasing their compression strength, as established in the literature. The aim of this paper was to incorporate an inorganic composite bioactive glass (60%SiO 2 -36%CaO -4%P 2 O 5 ) as a reinforcing agent in mechanical 3D scaffolds that must remain porous. Two strategies were adopted: a co-precipitation method to obtain a nanoparticulate dispersion of bioactive glass (BGNP) and a sol-gel method to combine a bioactive glass solution (BG) with a previously prepared chitosan polymer solution. Moreover, a lyophilization process was also used, generating highly porous scaffolds. Various aspects of the scaffold were evaluated, including the morphology, orientation and size of the pores, and mechanical strength, as obtained using the two synthetic methods. The data for compressive strength revealed increased strength after the incorporation of bioactive glass, which was more pronounced when utilizing the nanoscale bioactive glass.

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Spherical Bioactive Glass with Enhanced Rates of Hydroxyapatite Deposition and Hemostatic Activity

Cited by 228 publications

References 44 publications

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Highly elastomeric poly(3-hydroxyoctanoate) based natural polymer composite for enhanced keratinocyte regeneration

3d Nanocomposite Chitosan/Bioactive Glass Scaffolds Obtained Using Two Different Routes: An Evaluation of the Porous Structure and Mechanical Properties

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