1988
DOI: 10.1055/s-2006-962517
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Spermicidal Activity and Chemical Analysis ofPentapanax leschenaultii

Abstract: Triterpenic glycosides have been reported to have spermicidal potential, furthermore "CONSAP" cream, with these constituents as the active compounds, has reached clinical trial as a male contraceptive (1). Panax and other araliacious plants are rich sources of triterpenic glycosides. We recorded 100% immobilization of human spermatozoa by the ethanolic extract of the fresh leaves of Pentapanax leschenaultii (DC). Seem at the 2% level when assayed by the methods reported (2, 3). Since the plant has not been inv… Show more

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Cited by 5 publications
(6 citation statements)
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“…The anti-nutritional effects of saponins have been mainly studied using alfalfa saponins [62]. They also cause haemolysis of red blood cells [63], and have been demonstrated to have anti-spermal effects on human spermatozoa [64]. Specifically G. kola has the high content of alkaloids (4.66% ± 1.15%) and phytic acid (1.09% ± 0.10%) than those of the two other species.…”
Section: Quantitative Anti-nutrient Screening Of Kola Nutmentioning
confidence: 99%
“…The anti-nutritional effects of saponins have been mainly studied using alfalfa saponins [62]. They also cause haemolysis of red blood cells [63], and have been demonstrated to have anti-spermal effects on human spermatozoa [64]. Specifically G. kola has the high content of alkaloids (4.66% ± 1.15%) and phytic acid (1.09% ± 0.10%) than those of the two other species.…”
Section: Quantitative Anti-nutrient Screening Of Kola Nutmentioning
confidence: 99%
“…They also cause haemolysis of red blood cells and are toxic to rats [52]. Saponins from Bulbostermma paniculatum and Pentapamax leschenaultii have also been demonstrated to have anti-spermal effects on human spermatozoa [53,54]. They significantly inhibited acrosine activity of human sperms and the spermicidal effect was attributed to strong damage of the spermal plasma membrane [52].…”
Section: Resultsmentioning
confidence: 99%
“…Uptake of certain nutrients including glucose also and cholesterol also reduces in the gut through intraluminal physicochemical interaction. It has been proved that Saponins also peruse the antispermal effect (Su et al 1986 andPant et al 1989) and hypocholesterolemic effects (Esenwah et al 2008).…”
Section: Kidney Beanmentioning
confidence: 99%