Sperm retrieval success and testicular histopathology in idiopathic nonobstructive azoospermia

Das, Arighno; Halpern, Joshua A.; Darves-Bornoz, Annie; Patel, Mehul S.; Wren, James; Keeter, Mary Kate; Brannigan, Robert E.

doi:10.4103/aja.aja_137_19

Cited by 18 publications

(11 citation statements)

References 4 publications

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“…12,13 Interestingly, in a study stratifying men with idiopathic and nonidiopathic NOA, rates of SCO (both pure SCO and/or any component of SCO) were slightly higher in the idiopathic group (almost 60%) in comparison to the nonidiopathic group (up to 50%). 14 Furthermore, the SRR in our series was 42%, which is slightly lower than some other reports in NOA men. 3,12 This is likely secondary to exclusion of approximately 35% of patients without appropriate pathological data and from referral of complex patients to treat with prior failed sperm retrieval attempts, since our center is a quaternary referral center.…”

Section: Discussioncontrasting

confidence: 69%

Quantifying Heterogeneity of Testicular Histopathology in Men with Nonobstructive Azoospermia

et al. 2021

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Purpose:We sought to determine if testicular histopathological heterogeneity is associated with sperm retrieval rates (SRRs) in men with nonobstructive azoospermia (NOA) who are undergoing microdissection testicular sperm extraction (mTESE).Materials and Methods:All patients undergoing mTESE by a single, high-volume surgeon at a tertiary infertility referral center between 2010 and 2020 were evaluated. Pathology reports from testis biopsy at the time of mTESE reported by fellowship-trained genitourinary pathologists were reviewed. Testicular heterogeneity was correlated to absolute SRRs. Logistic regression was used to determine if heterogeneity was associated with sperm retrieval.Results:A total of 918 men with mTESE were included. Of these, 391 men (43%) had 1 pathology, 388 men (42%) had 2, 108 (12%) had 3, and 31 (3.4%) had 4. Overall, the most common histopathology was Sertoli-cell only, followed by maturation arrest. The overall SRR was 42% with a clinical intrauterine gestation rate of 30%. Increasing histopathological variety was associated with higher SRRs (p <0.01); a SRR of 33% was observed when one histopathological subtype was present vs 94% with 4 subtypes. Furthermore, men with any foci of spermatogenesis had higher SRRs.Conclusions:In men with NOA, increasing testicular histopathological heterogeneity is correlated with higher SRRs driven by the identification of focal areas of spermatogenesis. This is an important, although predictable, observation. While diagnostic biopsy is not routinely required, these findings emphasize the value of having histology to perhaps predict the chance of sperm retrieval for future mTESE procedures.

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Section: Discussioncontrasting

confidence: 69%

Quantifying Heterogeneity of Testicular Histopathology in Men with Nonobstructive Azoospermia

et al. 2021

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“…Meanwhile, human testis is also the priority of andrologists because testicular failure is the leading cause of male infertility 4 . Therefore, scientists have delved into both normal 5 , 6 and abnormal testes 7 - 9 , and detected mechanisms behind them especially those related to male infertility 10 , 11 . Although numerous approaches have been used to learn about human testis including cell experiments 12 , animal experiments 13 or even new methods like testicular organoid 14 , most of the above-mentioned methodologies are indirect.…”

Section: Introductionmentioning

confidence: 99%

Application of single-cell RNA sequencing on human testicular samples: a comprehensive review

Fan¹,

Ping²,

Ma³

et al. 2023

Int. J. Biol. Sci.

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“…This information has been demonstrated to provide a significant prognostic value for the sperm retrieval rate in microTESE procedures in previous studies. [5][6][7] Therefore, we conduct this study to describe the testicular histopathology of NOA men and assess factors associated with each histopathological pattern.…”

Section: Introductionmentioning

confidence: 99%

Testicular histopathology and associated factors in men with non-obstructive azoospermia

Thang¹,

Bắc²,

Thuong³

2022

TCNCYH

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The testicular histopathological characteristic in azoospermic men can significantly help in the diagnosis, prognosis and treatment of infertile patients. This study assessed the pathology specimens of 88 azoospermic infertile men seen at Hanoi Medical University Hospital. The most common histopathological pattern was Sertoli cell-only syndrome (40.9%), followed by hypospermatogenesis (29.5%) and Germ cell maturation arrest (18.1%). There were significant differences in the mean testicular volume and serum concentrations of LH and FSH among patients with different histopathology patterns. Analysis using multinomial logistic regression model showed only FSH was significantly associated with the severity of histopathological pattern. Each unit increase in the level of FSH was associated with a 7.1% increase in the odds of a more severe histopathology (95%CI: 1.01 - 1.12).

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Sperm retrieval success and testicular histopathology in idiopathic nonobstructive azoospermia

Cited by 18 publications

References 4 publications

Quantifying Heterogeneity of Testicular Histopathology in Men with Nonobstructive Azoospermia

Quantifying Heterogeneity of Testicular Histopathology in Men with Nonobstructive Azoospermia

Application of single-cell RNA sequencing on human testicular samples: a comprehensive review

Testicular histopathology and associated factors in men with non-obstructive azoospermia

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