Testicular histopathology and associated factors in men with non-obstructive azoospermia

Abstract

The testicular histopathological characteristic in azoospermic men can significantly help in the diagnosis, prognosis and treatment of infertile patients. This study assessed the pathology specimens of 88 azoospermic infertile men seen at Hanoi Medical University Hospital. The most common histopathological pattern was Sertoli cell-only syndrome (40.9%), followed by hypospermatogenesis (29.5%) and Germ cell maturation arrest (18.1%). There were significant differences in the mean testicular volume and serum concentrations of LH and FSH among patients with different histopathology patterns. Analysis using multinomial logistic regression model showed only FSH was significantly associated with the severity of histopathological pattern. Each unit increase in the level of FSH was associated with a 7.1% increase in the odds of a more severe histopathology (95%CI: 1.01 - 1.12).