Sperm aneuploidy among Chinese pesticide factory workers: Scoring by the FISH method

Padungtod, Chantana; Hassold, Terry; Millie, Elise; Ryan, Louise; Savitz, David A.; Christiani, D.C.; Xu, Xiping

doi:10.1002/(sici)1097-0274(199908)36:2<230::aid-ajim2>3.0.co;2-6

Cited by 96 publications

(62 citation statements)

References 19 publications

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“…Our findings were in agreement with the increased frequency of total sperm aneuploidies (0.30%) found in workers of a Chinese factory manufacturing methyl parathion, ethyl parathion, and metamidophos, compared with that of their controls (0.19%) (15). A moderately increased prevalence of chromosomes X, Y, and 18 sperm aneuploidies was also observed in these workers but nullisomy was not scored (15). Methodologic differences between laboratories and scorers preclude meaningful comparisons of absolute percents of sperm sex null aneuploidies among studies, because it is possible that differences between the Mexican and Chinese studies may have a technical component in addition to potential differences in exposure.…”

Section: Discussionsupporting

confidence: 91%

“…Recent evidence has shown that Turner syndrome has an estimated frequency of 1-2% among all clinically recognized pregnancies and that 70-80% of 46,XO patients retain the maternal X chromosome, because the paternal X chromosome is missing (23). Our findings were in agreement with the increased frequency of total sperm aneuploidies (0.30%) found in workers of a Chinese factory manufacturing methyl parathion, ethyl parathion, and metamidophos, compared with that of their controls (0.19%) (15). A moderately increased prevalence of chromosomes X, Y, and 18 sperm aneuploidies was also observed in these workers but nullisomy was not scored (15).…”

Section: Discussionsupporting

confidence: 89%

“…Exposure to organophosphorous pesticides (OP), used worldwide, has also been associated with hyperploidy/polyploidy in sperm (14,15) Aneuploidy is a common cause of poor reproductive outcomes in humans and is associated with severe medical problems in live newborns presenting genetic syndromes. In addition, chromosomes X and Y are more frequently damaged than autosomal chromosomes (16).…”

mentioning

confidence: 99%

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Organophosphorous Pesticide Exposure Increases the Frequency of Sperm Sex Null Aneuploidy

Recio¹,

Robbins²,

Ocampo-Gomez³

et al. 2001

Environmental Health Perspectives

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

See 1 more Smart Citation

Organophosphorous Pesticide Exposure Increases the Frequency of Sperm Sex Null Aneuploidy

Recio¹,

Robbins²,

Ocampo-Gomez³

et al. 2001

Environmental Health Perspectives

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“…Padungtod et al reported that exposure to methyl parathion, ethyl parathion and methamidophos in Chinese pesticide factory workers had a small effect on male reproductive hormones 17) and increased the prevalence of sperm aneuploidy 16) . Another study revealed a positive association between OP metabolite levels and sex null and total aneuploidy frequencies in Mexican agricultural workers 19) .…”

Section: Discussionmentioning

confidence: 99%

A Survey of Semen Indices in Insecticide Sprayers

Kamijima

Hibi

Gotoh

et al. 2004

Journal of Occupational Health

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A Survey of Semen Indices in InsecticideSprayers: Michihiro Kamijima, et al. Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine-This study aims at clarifying the semen indices of insecticide sprayers who are exposed mainly to organophosphorus and pyrethroid insecticides. Eighteen male sprayers out of 54 working for 9 companies in central Japan and 18 age-matched students or medical doctors as unexposed controls participated in detailed reproductive check-ups conducted in summer and the following winter. The sprayers were exposed to insecticides more in summer, the busiest season, than winter, the off-season (p<0.05). Erythrocyte true cholinesterase activities in the sprayers were lower than in the controls in summer (p<0.05), and decreased in significant association with the increase in exposure frequency. Testicular volumes in the sprayers tended to be smaller than in the controls (p=0.06). The serum testosterone concentration in winter in the sprayers was higher than in the controls (p<0.05), though luteinizing h o r m o n e a n d f o l l i c l e s t i m u l a t i n g h o r m o n e concentrations were not significantly different. The sperm counts and vitality were comparable between the groups, but detailed sperm motility analysis in summer revealed that the percentages of slow progressive and nonprogressive motile sperm were twice as high in the sprayers (p<0.05), and that of rapid progressive sperm tended to be lower (p=0.06). Such differences were not observed in winter. Differential sperm morphology counts showed that interaction of group and abstinence effects were significant in sperm Received Aug 19, 2003; Accepted Nov 28, 2003 Correspondence to: M. Kamijima, Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan (e-mail: kamijima@med.nagoya-u.ac.jp) with normal morphology and with head deformity only in the summer check-up. Despite possible inherent differences between the groups, the above seasondependent differences suggested that the observed lower semen quality in the sprayers was associated with pesticide spraying work.

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“…Muitos estudos têm sido realizados no sentido de verificar e quantificar os efeitos e o mecanismo de ação do Metamidofós no meio ambiente (8)(9)(10)(11), em matrizes vegetais (2,4,11-15) e ao homem (5,(16)(17)(18).…”

Section: Introductionunclassified

Análise De Resíduos Do Inseticida Metamidofós Em Soja E Determinação Final Por Cromatografia Em Fase Gasosa

Lima¹,

Tanaka²,

Nunes³

et al. 2003

PES

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Neste trabalho propõe-se método rápido de procedimentos de extração e clean up para determinações do inseticida Metamidofós em amostras de soja. Análises de amostras de soja seca e hidratada, fortificadas em níveis de 5 µg g-1, apresentaram recuperação média de 93-94% e coeficiente de variação de 17 a 31% com os sistemas adsorvente alumina/florisil e eluente metanol/ acetonitrila 1:3. Testes empregando sílica 15% desativada também mostraram eficiência com recuperação final de, aproximadamente, 75% e coeficientes de variação entre 18 a 27%. Cromatogramas com mínima interferência, nenhum efeito de matriz e boa eficiência na extração foram obtidos com a aplicação do método proposto. METHAMIDOPHOS INSECTICIDE RESIDUE ANALYSIS IN SOYBEAN AND FINAL DETERMINATION BY GAS CHROMATOGRAPHY Abstract A rapid method for extraction and clean up procedures for methamidophos insecticide determinations in soybean samples is proposed in this work. Analyses of dried and natural soybean samples fortified at 5 µg g-1 level showed recoveries average of 93-94% and variation coefficient ranging from 17 to 31% by using 3:1 Alumina/Florisil adsorbent system combined with 1:3 methanol/acetonitrile as eluent system. Tests employing 15% deactivated silica also showed to be efficient with final recovery close to 75% and variation coefficients varying from 18 to 27%. Chromatograms with minimal interferences, no matrix effects and good extraction efficiencies were recorded after application of the proposed method.

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Sperm aneuploidy among Chinese pesticide factory workers: Scoring by the FISH method

Cited by 96 publications

References 19 publications

Organophosphorous Pesticide Exposure Increases the Frequency of Sperm Sex Null Aneuploidy

Organophosphorous Pesticide Exposure Increases the Frequency of Sperm Sex Null Aneuploidy

A Survey of Semen Indices in Insecticide Sprayers

Análise De Resíduos Do Inseticida Metamidofós Em Soja E Determinação Final Por Cromatografia Em Fase Gasosa

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