Spektrophotometrische bestimmung von isoniazid mit 2,5-diphenyl-3-thiazolyl-tetrazoliumchlorid in arzneimitteln

Kovatscheva, E.; Wassileva-Alexandrova, P.; Иванова, В. П.

doi:10.1007/bf01204832

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several spectrophotometric procedures for the assay of INH employ sodium 1,2-naphthoquinone-4-sulphonate and cetyltrimethyl ammonium bromide [1]; vanadophosphoric acid [2]; 2,5-diphenyl-3-thiazolyltetrazolium chloride [3]; ohydroxyquinolphthalein-Pd (II)-hexadecyl trimethyl ammonium chloride complex [4]; 6,7-dichloroquinoline-5,8-dione [5]; 1-fluoro-2,4-dinitrobenzene [6]; pbenzoquinone [7]; chloranil or bromanil [8]; Fe(II) and 2,2-dipyridyl [9]; tetrazolium blue chloride [10]; ethyl 8-quinolyloxyacetate [11]; and N-bromosuccinimide with celestine blue [12]. The reported analytical procedures for the estimation of RTH in bulk samples and in unit dosage forms are reviewed in a recent work on the spectrophotometric determination of RTH [13].…”

Section: Introductionmentioning

confidence: 99%

Simple Sensitive Spectrophotometric Determination of Isoniazid and Ritodrine Hydrochloride

Naidu¹,

Kanchi²,

Kumar³

et al. 2005

J Anal Chem

View full text Add to dashboard Cite

A novel coupling reagent was used for simple, rapid, and sensitive spectrophotometric determination of isoniazid (1NH) and ritodrine hydrochloride (RTH) in pure form or in pharmaceutical preparations of it. The method is based on the diazotization of 4,4-methylene-bism -nitroaniline followed by a coupling reaction with either INH or RTH in hydrochloric acid medium. The resulting colored products have absorption maxima at 495 and 473 nm, respectively. Beer's law is obeyed in the concentration ranges of 0.1-15 µ g/mL and 0.1 − 17 µ g/mL. The method is applied for the analysis of INH/RTH in pharmaceutical preparations and the results agree favorably with the official and reported data. Common excipients used as additives in pharmaceuticals do not interfere in the proposed method. The method offers the advantages of simplicity, rapidity, and sensitivity without the need of extraction or heating.

show abstract